Tags

Type your tag names separated by a space and hit enter

The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee.
Rheumatology (Oxford). 2009 Mar; 48(3):277-80.R

Abstract

OBJECTIVE

To identify whether a shared genetic influence accounts for the occurrence of OA at different skeletal sites.

METHODS

Multivariate modelling of data on prevalent radiographic OA at the hand (DIP, PIP and CMC joints), hip and knee joints assessed in 992 monozygotic and dizygotic female twin participants from the TwinsUK Registry.

RESULTS

OA at all the five joint sites was heritable. Genetic influences were strongly correlated among joints in the hand; however, there was little evidence of common genetic pathways to account for the co-occurrence of OA at the hand, hip and knee.

CONCLUSIONS

While genetic influences are important in explaining the variation in occurrence of OA at the hand, hip and knee, there is no evidence that common or shared genetic factors determine the occurrence of disease across all these skeletal sites. The findings suggest that there are important aetiological differences in the disease that are site-specific in women. These results have implications for the design of studies examining the genetic basis of OA as well as for strategies aimed at preventing and treating the disease.

Links

PMC Free PDF
PMC Free Full Text
Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

MacGregor AJ
School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK. a.macgregor@uea.ac.uk
Li Q
No affiliation info available
Spector TD
No affiliation info available
Williams FM
No affiliation info available

MeSH

AdultAgedDiseases in TwinsFemaleGenetic LinkageGenetic Predisposition to DiseaseHand JointsHumansMiddle AgedOsteoarthritisOsteoarthritis, HipOsteoarthritis, KneePhenotypeRadiographyTwins, DizygoticTwins, MonozygoticYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

19153142

Clinical Trial Links

The Marigot Osteoarthritis Nutritional Intervention (MOANi) Trial

Citation

MacGregor, A J., et al. "The Genetic Influence On Radiographic Osteoarthritis Is Site Specific at the Hand, Hip and Knee." Rheumatology (Oxford, England), vol. 48, no. 3, 2009, pp. 277-80.
MacGregor AJ, Li Q, Spector TD, et al. The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee. Rheumatology (Oxford). 2009;48(3):277-80.
MacGregor, A. J., Li, Q., Spector, T. D., & Williams, F. M. (2009). The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee. Rheumatology (Oxford, England), 48(3), 277-80. https://doi.org/10.1093/rheumatology/ken475
MacGregor AJ, et al. The Genetic Influence On Radiographic Osteoarthritis Is Site Specific at the Hand, Hip and Knee. Rheumatology (Oxford). 2009;48(3):277-80. PubMed PMID: 19153142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee. AU - MacGregor,A J, AU - Li,Q, AU - Spector,T D, AU - Williams,F M K, Y1 - 2009/01/19/ PY - 2009/1/21/entrez PY - 2009/1/21/pubmed PY - 2009/11/10/medline SP - 277 EP - 80 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 48 IS - 3 N2 - OBJECTIVE: To identify whether a shared genetic influence accounts for the occurrence of OA at different skeletal sites. METHODS: Multivariate modelling of data on prevalent radiographic OA at the hand (DIP, PIP and CMC joints), hip and knee joints assessed in 992 monozygotic and dizygotic female twin participants from the TwinsUK Registry. RESULTS: OA at all the five joint sites was heritable. Genetic influences were strongly correlated among joints in the hand; however, there was little evidence of common genetic pathways to account for the co-occurrence of OA at the hand, hip and knee. CONCLUSIONS: While genetic influences are important in explaining the variation in occurrence of OA at the hand, hip and knee, there is no evidence that common or shared genetic factors determine the occurrence of disease across all these skeletal sites. The findings suggest that there are important aetiological differences in the disease that are site-specific in women. These results have implications for the design of studies examining the genetic basis of OA as well as for strategies aimed at preventing and treating the disease. SN - 1462-0332 UR - https://www.unboundmedicine.com/medline/citation/19153142/The_genetic_influence_on_radiographic_osteoarthritis_is_site_specific_at_the_hand_hip_and_knee_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/ken475 DB - PRIME DP - Unbound Medicine ER -