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Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety.
Psychol Med. 2009 Jul; 39(7):1177-87.PM

Abstract

BACKGROUND

Social anxiety often involves a combination of hypervigilance and avoidance to potentially warning signals including the facial expression of emotions. Functional imaging has demonstrated an increase in amygdala response to emotional faces in subjects with social anxiety. Nevertheless, it is unclear to what extent visual areas processing faces influence amygdala reactivity in different socially anxious individuals. We assessed the influence of the fusiform gyrus activation on amygdala response to emotional faces in the non-clinical range of social anxiety.

METHOD

Twenty-two normal subjects showing a wide range in social anxiety scores were examined using functional magnetic resonance imaging (fMRI) during the processing of happy and fearful faces. A dimensional analysis approach was used involving voxel-wise mapping of the correlation between subjects' social anxiety scores and amygdala activation, before and after controlling for fusiform gyrus activation.

RESULTS

We observed that only after controlling for subjects' level of activation of the fusiform gyrus was there an association between social anxiety ratings and amygdala response to both happy and fearful faces. The fusiform gyrus influence was more robust during the fear condition. Of note, fusiform gyrus response to fearful faces showed a negative correlation with additional behavioral assessments related to avoidance, including social anxiety scores, harm avoidance and sensitivity to punishment.

CONCLUSIONS

Relevant interactions among the emotional face-processing stages exist in the non-clinical range of social anxiety that may ultimately attenuate amygdala responses. Future research will help to establish the role of this effect in a clinical context.

Authors+Show Affiliations

Institut d'Alta Tecnologia-PRBB, Department of Magnetic Resonance, CRC Corporació Sanitària, Barcelona, Spain. jpujol@crccorp.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19154647

Citation

Pujol, J, et al. "Influence of the Fusiform Gyrus On Amygdala Response to Emotional Faces in the Non-clinical Range of Social Anxiety." Psychological Medicine, vol. 39, no. 7, 2009, pp. 1177-87.
Pujol J, Harrison BJ, Ortiz H, et al. Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. Psychol Med. 2009;39(7):1177-87.
Pujol, J., Harrison, B. J., Ortiz, H., Deus, J., Soriano-Mas, C., López-Solà, M., Yücel, M., Perich, X., & Cardoner, N. (2009). Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. Psychological Medicine, 39(7), 1177-87. https://doi.org/10.1017/S003329170800500X
Pujol J, et al. Influence of the Fusiform Gyrus On Amygdala Response to Emotional Faces in the Non-clinical Range of Social Anxiety. Psychol Med. 2009;39(7):1177-87. PubMed PMID: 19154647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. AU - Pujol,J, AU - Harrison,B J, AU - Ortiz,H, AU - Deus,J, AU - Soriano-Mas,C, AU - López-Solà,M, AU - Yücel,M, AU - Perich,X, AU - Cardoner,N, Y1 - 2009/01/21/ PY - 2009/1/22/entrez PY - 2009/1/22/pubmed PY - 2009/8/29/medline SP - 1177 EP - 87 JF - Psychological medicine JO - Psychol Med VL - 39 IS - 7 N2 - BACKGROUND: Social anxiety often involves a combination of hypervigilance and avoidance to potentially warning signals including the facial expression of emotions. Functional imaging has demonstrated an increase in amygdala response to emotional faces in subjects with social anxiety. Nevertheless, it is unclear to what extent visual areas processing faces influence amygdala reactivity in different socially anxious individuals. We assessed the influence of the fusiform gyrus activation on amygdala response to emotional faces in the non-clinical range of social anxiety. METHOD: Twenty-two normal subjects showing a wide range in social anxiety scores were examined using functional magnetic resonance imaging (fMRI) during the processing of happy and fearful faces. A dimensional analysis approach was used involving voxel-wise mapping of the correlation between subjects' social anxiety scores and amygdala activation, before and after controlling for fusiform gyrus activation. RESULTS: We observed that only after controlling for subjects' level of activation of the fusiform gyrus was there an association between social anxiety ratings and amygdala response to both happy and fearful faces. The fusiform gyrus influence was more robust during the fear condition. Of note, fusiform gyrus response to fearful faces showed a negative correlation with additional behavioral assessments related to avoidance, including social anxiety scores, harm avoidance and sensitivity to punishment. CONCLUSIONS: Relevant interactions among the emotional face-processing stages exist in the non-clinical range of social anxiety that may ultimately attenuate amygdala responses. Future research will help to establish the role of this effect in a clinical context. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/19154647/Influence_of_the_fusiform_gyrus_on_amygdala_response_to_emotional_faces_in_the_non_clinical_range_of_social_anxiety_ L2 - https://www.cambridge.org/core/product/identifier/S003329170800500X/type/journal_article DB - PRIME DP - Unbound Medicine ER -