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Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults.
Metabolism. 2009 Feb; 58(2):254-62.M

Abstract

The objective of the study was to determine whether short-term antioxidant (AOX) supplementation affects insulin sensitivity, endothelial adhesion molecule levels, and oxidative stress in overweight young adults. A randomized, double-blind, controlled study tested the effects of AOXs on measures of insulin sensitivity (homeostasis model assessment [HOMA]) and quantitative insulin sensitivity check index), endothelial adhesion molecules (soluble intercellular adhesion molecule-1, vascular adhesion molecule, and endothelial-leukocyte adhesion molecule-1), adiponectin, and oxidative stress (lipid hydroperoxides) in overweight and normal-weight individuals (N = 48, 18-30 years). Participants received either AOX (vitamin E, 800 IU; vitamin C, 500 mg; beta-carotene, 10 mg) or placebo for 8 weeks. The HOMA values were initially higher in the overweight subjects and were lowered with AOX by week 8 (15% reduction, P = .02). Adiponectin increased in both AOX groups. Soluble intercellular adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1 decreased in overweight AOX-treated groups by 6% and 13%, respectively (P < .05). Plasma lipid hydroperoxides were reduced by 0.31 and 0.70 nmol/mL in the normal-weight and overweight AOX-treated groups, respectively, by week 8 (P < .05). Antioxidant supplementation moderately lowers HOMA and endothelial adhesion molecule levels in overweight young adults. A potential mechanism to explain this finding is the reduction in oxidative stress by AOX. Long-term studies are needed to determine whether AOXs are effective in suppressing diabetes or vascular activation over time.

Authors+Show Affiliations

Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, PO Box 112727, FL 32608, USA. vincehk@ortho.ufl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19154960

Citation

Vincent, Heather K., et al. "Effects of Antioxidant Supplementation On Insulin Sensitivity, Endothelial Adhesion Molecules, and Oxidative Stress in Normal-weight and Overweight Young Adults." Metabolism: Clinical and Experimental, vol. 58, no. 2, 2009, pp. 254-62.
Vincent HK, Bourguignon CM, Weltman AL, et al. Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism. 2009;58(2):254-62.
Vincent, H. K., Bourguignon, C. M., Weltman, A. L., Vincent, K. R., Barrett, E., Innes, K. E., & Taylor, A. G. (2009). Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism: Clinical and Experimental, 58(2), 254-62. https://doi.org/10.1016/j.metabol.2008.09.022
Vincent HK, et al. Effects of Antioxidant Supplementation On Insulin Sensitivity, Endothelial Adhesion Molecules, and Oxidative Stress in Normal-weight and Overweight Young Adults. Metabolism. 2009;58(2):254-62. PubMed PMID: 19154960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. AU - Vincent,Heather K, AU - Bourguignon,Cheryl M, AU - Weltman,Arthur L, AU - Vincent,Kevin R, AU - Barrett,Eugene, AU - Innes,Karen E, AU - Taylor,Ann G, PY - 2008/07/08/received PY - 2008/09/29/accepted PY - 2009/1/22/entrez PY - 2009/1/22/pubmed PY - 2009/2/28/medline SP - 254 EP - 62 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 2 N2 - The objective of the study was to determine whether short-term antioxidant (AOX) supplementation affects insulin sensitivity, endothelial adhesion molecule levels, and oxidative stress in overweight young adults. A randomized, double-blind, controlled study tested the effects of AOXs on measures of insulin sensitivity (homeostasis model assessment [HOMA]) and quantitative insulin sensitivity check index), endothelial adhesion molecules (soluble intercellular adhesion molecule-1, vascular adhesion molecule, and endothelial-leukocyte adhesion molecule-1), adiponectin, and oxidative stress (lipid hydroperoxides) in overweight and normal-weight individuals (N = 48, 18-30 years). Participants received either AOX (vitamin E, 800 IU; vitamin C, 500 mg; beta-carotene, 10 mg) or placebo for 8 weeks. The HOMA values were initially higher in the overweight subjects and were lowered with AOX by week 8 (15% reduction, P = .02). Adiponectin increased in both AOX groups. Soluble intercellular adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1 decreased in overweight AOX-treated groups by 6% and 13%, respectively (P < .05). Plasma lipid hydroperoxides were reduced by 0.31 and 0.70 nmol/mL in the normal-weight and overweight AOX-treated groups, respectively, by week 8 (P < .05). Antioxidant supplementation moderately lowers HOMA and endothelial adhesion molecule levels in overweight young adults. A potential mechanism to explain this finding is the reduction in oxidative stress by AOX. Long-term studies are needed to determine whether AOXs are effective in suppressing diabetes or vascular activation over time. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19154960/Effects_of_antioxidant_supplementation_on_insulin_sensitivity_endothelial_adhesion_molecules_and_oxidative_stress_in_normal_weight_and_overweight_young_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00359-4 DB - PRIME DP - Unbound Medicine ER -