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[High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers].
Turk Kardiyol Dern Ars. 2008 Sep; 36(6):368-75.TK

Abstract

OBJECTIVES

We investigated the relationship between high sensitivity C-reactive protein (hs-CRP) activity and autonomic nervous activity using heart rate variability in smokers.

STUDY DESIGN

The study consisted of 136 healthy subjects, including 66 smokers (35 women, 31 men; mean age 36 years) and 70 nonsmokers (43 women, 27 men; mean age 34 years). Serum samples were collected from all the subjects. Three-channel, 24-hr Holter monitoring was performed to derive the mean heart rate, standard deviation of normal NN intervals (SDNN), standard deviation of 5-minute mean NN intervals (SDANN), root mean square differences of successive NN intervals (RMSSD), high- (HF) and low- (LF) frequency power components, and the LF/HF ratio.

RESULTS

In smokers, the mean duration of smoking was 13.6+/-8.2 years (range 3 to 45 years), and the mean number of cigarettes consumed per day was 16.3+/-7.1 (range 5 to 40). Smokers exhibited significantly higher mean heart rate, hs-CRP and fibrinogen levels, mean platelet volume, white blood cell count, LF, and LF/HF ratio, with significantly lower SDNN, SDANN, RMSSD, and HF values. In smokers, hs-CRP was correlated with the number of cigarettes consumed per day, duration of smoking, fibrinogen level, mean platelet volume, white blood cell count, LF, and LF/HF ratio, and inversely correlated with HF, SDNN, and SDANN. Even smoking a single cigarette resulted in an acute, 0.07-fold increase in the hs-CRP level (p<0.0001). In linear regression analysis, both the number of cigarettes consumed per day (beta=0.52, p=0.011) and duration of smoking (beta=0.073, p<0.0001) had an independent effect on the hs-CRP level.

CONCLUSION

Smoking both impairs the sympathovagal balance and increases the hs-CRP activity in otherwise healthy smokers, the combination of which would probably contribute to a higher rate of cardiovascular events.

Authors+Show Affiliations

Department of Cardiology, Medicine Faculty of Dicle University, Diyarbakir, Turkey. droalyan@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

tur

PubMed ID

19155639

Citation

Alyan, Omer, et al. "[High Levels of High-sensitivity C-reactive Protein and Impaired Autonomic Activity in Smokers]." Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, vol. 36, no. 6, 2008, pp. 368-75.
Alyan O, Kaçmaz F, Ozdemir O, et al. [High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers]. Turk Kardiyol Dern Ars. 2008;36(6):368-75.
Alyan, O., Kaçmaz, F., Ozdemir, O., Karahan, Z., Taşkesen, T., Iyem, H., Alan, S., Karadede, A., & Ilkay, E. (2008). [High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers]. Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, 36(6), 368-75.
Alyan O, et al. [High Levels of High-sensitivity C-reactive Protein and Impaired Autonomic Activity in Smokers]. Turk Kardiyol Dern Ars. 2008;36(6):368-75. PubMed PMID: 19155639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers]. AU - Alyan,Omer, AU - Kaçmaz,Fehmi, AU - Ozdemir,Ozcan, AU - Karahan,Zülküf, AU - Taşkesen,Tuncay, AU - Iyem,Hikmet, AU - Alan,Sait, AU - Karadede,Aziz, AU - Ilkay,Erdoğan, PY - 2009/1/22/entrez PY - 2009/1/22/pubmed PY - 2009/8/19/medline SP - 368 EP - 75 JF - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir JO - Turk Kardiyol Dern Ars VL - 36 IS - 6 N2 - OBJECTIVES: We investigated the relationship between high sensitivity C-reactive protein (hs-CRP) activity and autonomic nervous activity using heart rate variability in smokers. STUDY DESIGN: The study consisted of 136 healthy subjects, including 66 smokers (35 women, 31 men; mean age 36 years) and 70 nonsmokers (43 women, 27 men; mean age 34 years). Serum samples were collected from all the subjects. Three-channel, 24-hr Holter monitoring was performed to derive the mean heart rate, standard deviation of normal NN intervals (SDNN), standard deviation of 5-minute mean NN intervals (SDANN), root mean square differences of successive NN intervals (RMSSD), high- (HF) and low- (LF) frequency power components, and the LF/HF ratio. RESULTS: In smokers, the mean duration of smoking was 13.6+/-8.2 years (range 3 to 45 years), and the mean number of cigarettes consumed per day was 16.3+/-7.1 (range 5 to 40). Smokers exhibited significantly higher mean heart rate, hs-CRP and fibrinogen levels, mean platelet volume, white blood cell count, LF, and LF/HF ratio, with significantly lower SDNN, SDANN, RMSSD, and HF values. In smokers, hs-CRP was correlated with the number of cigarettes consumed per day, duration of smoking, fibrinogen level, mean platelet volume, white blood cell count, LF, and LF/HF ratio, and inversely correlated with HF, SDNN, and SDANN. Even smoking a single cigarette resulted in an acute, 0.07-fold increase in the hs-CRP level (p<0.0001). In linear regression analysis, both the number of cigarettes consumed per day (beta=0.52, p=0.011) and duration of smoking (beta=0.073, p<0.0001) had an independent effect on the hs-CRP level. CONCLUSION: Smoking both impairs the sympathovagal balance and increases the hs-CRP activity in otherwise healthy smokers, the combination of which would probably contribute to a higher rate of cardiovascular events. SN - 1016-5169 UR - https://www.unboundmedicine.com/medline/citation/19155639/[High_levels_of_high_sensitivity_C_reactive_protein_and_impaired_autonomic_activity_in_smokers]_ L2 - https://www.journalagent.com/pubmed/linkout.asp?ISSN=1016-5169&amp;PMID=19155639 DB - PRIME DP - Unbound Medicine ER -