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[HPLC determination of chemical constituents produced in Radix Polygoni Multiflori after processing].
Zhongguo Zhong Yao Za Zhi. 2008 Oct; 33(20):2326-9.ZZ

Abstract

OBJECTIVE

To analysis the changes of two chemical constituents, namely 2, 3-dihydro-3, 5- dihydroxy-6-methyl-4H-pyran-4-one (DDMP) and 5-hydryoxymethyl-furfural (5-HMF) produced in Radix Polygoni Multiflori after processing, with processing time, and to determine the contents of 5-HMF in samples of Radix Polygoni Multiflori and Radix Polygoni Multiflori preparata.

METHOD

An HPLC method was applied with a Zobax SB-C18 (3.9 mm x 150 mm, 5 microm) column by a elution using methanol-water (10: 90) as the mobile phase. The detection was set at UV 280 nm.

RESULT

The contents of DDMP were increasing with the processing time until 24 hour, followed by a decrease until 60 hour process. The contents of 5-HMF were increasing gradually throughout the 60 hour steaming process. The contents of 5-HMF in 11 samples of Radix Polygoni Multiflori preparata were from 0.013% to 0.101%, and only one in 4 samples of Radix Polygoni Multiflori containing trace amount of 5-HMF.

CONCLUSION

The chemical components in Radix Polygoni Multiflori were changed during the processing procedures. Therefore, the processing of Radix Polygoni Multiflori should be controlled and standardized.

Authors+Show Affiliations

Institute of Chinese Medicine Basic Theory, Beijing 100700, China. zhen-li_liu@sina.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19157118

Citation

Liu, Zhen-Li, et al. "[HPLC Determination of Chemical Constituents Produced in Radix Polygoni Multiflori After Processing]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 33, no. 20, 2008, pp. 2326-9.
Liu ZL, Song ZQ, Chao ZM, et al. [HPLC determination of chemical constituents produced in Radix Polygoni Multiflori after processing]. Zhongguo Zhong Yao Za Zhi. 2008;33(20):2326-9.
Liu, Z. L., Song, Z. Q., Chao, Z. M., Lv, S. Y., Wang, C., & Li, L. F. (2008). [HPLC determination of chemical constituents produced in Radix Polygoni Multiflori after processing]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 33(20), 2326-9.
Liu ZL, et al. [HPLC Determination of Chemical Constituents Produced in Radix Polygoni Multiflori After Processing]. Zhongguo Zhong Yao Za Zhi. 2008;33(20):2326-9. PubMed PMID: 19157118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [HPLC determination of chemical constituents produced in Radix Polygoni Multiflori after processing]. AU - Liu,Zhen-Li, AU - Song,Zhi-Qian, AU - Chao,Zhi-Mao, AU - Lv,Shu-Yi, AU - Wang,Chun, AU - Li,Lin-Fu, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/5/15/medline SP - 2326 EP - 9 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 33 IS - 20 N2 - OBJECTIVE: To analysis the changes of two chemical constituents, namely 2, 3-dihydro-3, 5- dihydroxy-6-methyl-4H-pyran-4-one (DDMP) and 5-hydryoxymethyl-furfural (5-HMF) produced in Radix Polygoni Multiflori after processing, with processing time, and to determine the contents of 5-HMF in samples of Radix Polygoni Multiflori and Radix Polygoni Multiflori preparata. METHOD: An HPLC method was applied with a Zobax SB-C18 (3.9 mm x 150 mm, 5 microm) column by a elution using methanol-water (10: 90) as the mobile phase. The detection was set at UV 280 nm. RESULT: The contents of DDMP were increasing with the processing time until 24 hour, followed by a decrease until 60 hour process. The contents of 5-HMF were increasing gradually throughout the 60 hour steaming process. The contents of 5-HMF in 11 samples of Radix Polygoni Multiflori preparata were from 0.013% to 0.101%, and only one in 4 samples of Radix Polygoni Multiflori containing trace amount of 5-HMF. CONCLUSION: The chemical components in Radix Polygoni Multiflori were changed during the processing procedures. Therefore, the processing of Radix Polygoni Multiflori should be controlled and standardized. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/19157118/[HPLC_determination_of_chemical_constituents_produced_in_Radix_Polygoni_Multiflori_after_processing]_ DB - PRIME DP - Unbound Medicine ER -