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[Pathological change in the brain of mice infected with Angiostrongylus cantonensis].

Abstract

OBJECTIVE

To observe the pathological change in the brain of Angiostrongylus cantonensis-infected mouse.

METHODS

Forty-eight mice were orally infected each with 40 third stage larvae of A. cantonensis, 3 mice were sacrificed at 7, 10, 13, 16, 19, 22, 25, 28 days postinfection respectively for worm recovery, and another 3 mice were for observing the histopathological change in tissue sections of the brain.

RESULTS

Ten days postinfection, worms were found in the brain of the infected mice with a mean worm number of (7.0+/-1.7) per mouse. The highest number of worms was found at 16 days postinfection, with a mean of (23.7+/-4.9) per mouse. Notable symptoms of nervous system were seen on 15 days postinfection. Most mice died around 22 days postinfection. Histological examination revealed mechanical damages. Cavities and inflammation were observed in the brain parenchyma. Worms were seen in the subarachnoid space. Meningitis-like signs started at 13 days and aggravated then.

CONCLUSIONS

Infection of A. cantonensis causes pathological change in mouse brain and the process is aggravating with postinfection time.

Authors+Show Affiliations

Department of Parasitology, Zhongshan Medical College, Sun Yat-sen University, Key Laboratory of Tropical Disease Control and Prevention of the Ministry of Education, Guangzhou 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19157298

Citation

Guo, Peng-Juan, et al. "[Pathological Change in the Brain of Mice Infected With Angiostrongylus Cantonensis]." Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases, vol. 26, no. 5, 2008, pp. 353-5.
Guo PJ, Zhan XM, Gan M, et al. [Pathological change in the brain of mice infected with Angiostrongylus cantonensis]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008;26(5):353-5.
Guo, P. J., Zhan, X. M., Gan, M., Pan, Z. H., Yu, Y. J., Zhang, M. C., Qu, Z. Y., Li, Z. Y., & He, A. (2008). [Pathological change in the brain of mice infected with Angiostrongylus cantonensis]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases, 26(5), 353-5.
Guo PJ, et al. [Pathological Change in the Brain of Mice Infected With Angiostrongylus Cantonensis]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Oct 30;26(5):353-5. PubMed PMID: 19157298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pathological change in the brain of mice infected with Angiostrongylus cantonensis]. AU - Guo,Peng-Juan, AU - Zhan,Xi-Mei, AU - Gan,Ming, AU - Pan,Zhi-Hua, AU - Yu,Yan-Jie, AU - Zhang,Mei-Chun, AU - Qu,Zhen-Yu, AU - Li,Zhuo-Ya, AU - He,Ai, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/7/10/medline SP - 353 EP - 5 JF - Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases JO - Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi VL - 26 IS - 5 N2 - OBJECTIVE: To observe the pathological change in the brain of Angiostrongylus cantonensis-infected mouse. METHODS: Forty-eight mice were orally infected each with 40 third stage larvae of A. cantonensis, 3 mice were sacrificed at 7, 10, 13, 16, 19, 22, 25, 28 days postinfection respectively for worm recovery, and another 3 mice were for observing the histopathological change in tissue sections of the brain. RESULTS: Ten days postinfection, worms were found in the brain of the infected mice with a mean worm number of (7.0+/-1.7) per mouse. The highest number of worms was found at 16 days postinfection, with a mean of (23.7+/-4.9) per mouse. Notable symptoms of nervous system were seen on 15 days postinfection. Most mice died around 22 days postinfection. Histological examination revealed mechanical damages. Cavities and inflammation were observed in the brain parenchyma. Worms were seen in the subarachnoid space. Meningitis-like signs started at 13 days and aggravated then. CONCLUSIONS: Infection of A. cantonensis causes pathological change in mouse brain and the process is aggravating with postinfection time. SN - 1000-7423 UR - https://www.unboundmedicine.com/medline/citation/19157298/[Pathological_change_in_the_brain_of_mice_infected_with_Angiostrongylus_cantonensis]_ DB - PRIME DP - Unbound Medicine ER -