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Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension.
Nutr Metab Cardiovasc Dis. 2009 Sep; 19(7):491-7.NM

Abstract

BACKGROUND AND AIMS

Azuki beans (Vigna angularis) contain polyphenols such as proanthocyanidins that exhibit potential radical scavenging activities. We herein investigated the effects of polyphenol-containing azuki bean extract (ABE) on elevated blood pressure, nitric oxide (NO) production, and expressions of endothelial NO synthase (eNOS), inducible NOS (iNOS), and caveolin-1 proteins in the aorta and kidney of chronically hypertensive rats.

METHODS AND RESULTS

Spontaneously hypertensive rats (SHRs/Izm) with approximately 200 mm Hg systolic blood pressure (SBP) were randomly divided into 2 groups fed either 0% or 0.9% ABE-containing diet. Age-matched normotensive Wistar-Kyoto rats were used as the control. The content of 24-h urinary nitrate/nitrite (NOx) excretion was measured to evaluate NO production. After 8 weeks of treatment, the eNOS, iNOS, and caveolin-1 protein expressions in the aorta and kidney were analyzed by western blotting. The SBP of the ABE-treated SHR was significantly lower than that of the untreated SHR. The level of 24-h urinary NOx excretion was significantly higher in the ABE-treated SHR than in the untreated SHR. The eNOS and iNOS expressions in the aorta and kidney were remarkably upregulated in the untreated SHR but suppressed in the ABE-treated SHR. The vascular and renal caveolin-1 expressions were upregulated in the ABE-treated SHR.

CONCLUSIONS

ABE reduced the elevated blood pressure and increased NO production in long-term treatment. It may be associated with the modulation of eNOS and iNOS protein expressions in the aorta and kidney during the development of hypertension.

Authors+Show Affiliations

Department of Life Sciences, Graduate School of Health Sciences, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-8505, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19157815

Citation

Mukai, Y, and S Sato. "Polyphenol-containing Azuki Bean (Vigna Angularis) Extract Attenuates Blood Pressure Elevation and Modulates Nitric Oxide Synthase and Caveolin-1 Expressions in Rats With Hypertension." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 7, 2009, pp. 491-7.
Mukai Y, Sato S. Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutr Metab Cardiovasc Dis. 2009;19(7):491-7.
Mukai, Y., & Sato, S. (2009). Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(7), 491-7. https://doi.org/10.1016/j.numecd.2008.09.007
Mukai Y, Sato S. Polyphenol-containing Azuki Bean (Vigna Angularis) Extract Attenuates Blood Pressure Elevation and Modulates Nitric Oxide Synthase and Caveolin-1 Expressions in Rats With Hypertension. Nutr Metab Cardiovasc Dis. 2009;19(7):491-7. PubMed PMID: 19157815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. AU - Mukai,Y, AU - Sato,S, Y1 - 2009/01/20/ PY - 2008/03/24/received PY - 2008/07/26/revised PY - 2008/09/15/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/10/6/medline SP - 491 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 7 N2 - BACKGROUND AND AIMS: Azuki beans (Vigna angularis) contain polyphenols such as proanthocyanidins that exhibit potential radical scavenging activities. We herein investigated the effects of polyphenol-containing azuki bean extract (ABE) on elevated blood pressure, nitric oxide (NO) production, and expressions of endothelial NO synthase (eNOS), inducible NOS (iNOS), and caveolin-1 proteins in the aorta and kidney of chronically hypertensive rats. METHODS AND RESULTS: Spontaneously hypertensive rats (SHRs/Izm) with approximately 200 mm Hg systolic blood pressure (SBP) were randomly divided into 2 groups fed either 0% or 0.9% ABE-containing diet. Age-matched normotensive Wistar-Kyoto rats were used as the control. The content of 24-h urinary nitrate/nitrite (NOx) excretion was measured to evaluate NO production. After 8 weeks of treatment, the eNOS, iNOS, and caveolin-1 protein expressions in the aorta and kidney were analyzed by western blotting. The SBP of the ABE-treated SHR was significantly lower than that of the untreated SHR. The level of 24-h urinary NOx excretion was significantly higher in the ABE-treated SHR than in the untreated SHR. The eNOS and iNOS expressions in the aorta and kidney were remarkably upregulated in the untreated SHR but suppressed in the ABE-treated SHR. The vascular and renal caveolin-1 expressions were upregulated in the ABE-treated SHR. CONCLUSIONS: ABE reduced the elevated blood pressure and increased NO production in long-term treatment. It may be associated with the modulation of eNOS and iNOS protein expressions in the aorta and kidney during the development of hypertension. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19157815/Polyphenol_containing_azuki_bean__Vigna_angularis__extract_attenuates_blood_pressure_elevation_and_modulates_nitric_oxide_synthase_and_caveolin_1_expressions_in_rats_with_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00191-9 DB - PRIME DP - Unbound Medicine ER -