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[The effect of low-protein diet supplemented with ketoacids in patients with chronic renal failure].
Orv Hetil. 2009 Feb 01; 150(5):217-24.OH

Abstract

It is known that dietary protein restriction slows the progression of chronic renal disease. If daily protein intake is less than 0.5-0.6 g/kgbw, the diet has to be supplemented with essential aminoacids/ketoacids. In this study the authors evaluate the long-term effect of low-protein diet supplemented with ketoacids on the progression of chronic renal failure, calcium and phosphorus metabolism, nutritional status, the compliance of patients and the permanent dietary education for the compliance. 51 predialysis patients have been treated with ketoacids supplemented low-protein diet during 12-57 months (mean treatment period: 26 months). Serum creatinine raised from 349.72+/-78.04 micromol/l to 460.66+/-206.66 micromol/l (27 micromol/l/year or 2.3 micromol/l/month), glomerular filtration rate (GFR) decreased from 21.52+/-7.84 ml/min to 18.22+/-7.76 ml/min (0.83 ml/min/year or 0.07 ml/min/month). The slope of 1/serum creatinine versus time was 0.0018 by linear regression analysis. Serum parathormon decreased significantly, but serum calcium and phosphorus did not change. Nutritional status of patients did not change significantly during the follow-up period. Protein intake decreased significantly and remained at this lower level during the treatment period. According to results: low-protein diet supplemented with ketoacids was effective in slowing progression of chronic renal failure, decreased PTH, did not change nutritional status. With permanently and good education it was possible to keep patients on low-protein diet for a long period.

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Authors+Show Affiliations

Molnár M
Fresenius Medical Care Dialízis Centrum Szigetvár Szt. István ltp. 7. 7900. marta.molnar@fmc-ag.com
Szekeresné Izsák M
No affiliation info available
Nagy J
No affiliation info available
Figler M
No affiliation info available

MeSH

AdultAgedCalciumCreatinineDiet, Protein-RestrictedDietary SupplementsDisease ProgressionFemaleGlomerular Filtration RateHumansKeto AcidsKidney Failure, ChronicLinear ModelsMaleMiddle AgedNutritional StatusParathyroid HormonePatient CompliancePatient Education as TopicPhosphorusTime Factors

Pub Type(s)

English Abstract
Journal Article

Language

hun

PubMed ID

19158020

Citation

Molnár, Márta, et al. "[The Effect of Low-protein Diet Supplemented With Ketoacids in Patients With Chronic Renal Failure]." Orvosi Hetilap, vol. 150, no. 5, 2009, pp. 217-24.
Molnár M, Szekeresné Izsák M, Nagy J, et al. [The effect of low-protein diet supplemented with ketoacids in patients with chronic renal failure]. Orv Hetil. 2009;150(5):217-24.
Molnár, M., Szekeresné Izsák, M., Nagy, J., & Figler, M. (2009). [The effect of low-protein diet supplemented with ketoacids in patients with chronic renal failure]. Orvosi Hetilap, 150(5), 217-24. https://doi.org/10.1556/OH.2009.28540
Molnár M, et al. [The Effect of Low-protein Diet Supplemented With Ketoacids in Patients With Chronic Renal Failure]. Orv Hetil. 2009 Feb 1;150(5):217-24. PubMed PMID: 19158020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of low-protein diet supplemented with ketoacids in patients with chronic renal failure]. AU - Molnár,Márta, AU - Szekeresné Izsák,Margit, AU - Nagy,Judit, AU - Figler,Mária, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/4/2/medline SP - 217 EP - 24 JF - Orvosi hetilap JO - Orv Hetil VL - 150 IS - 5 N2 - It is known that dietary protein restriction slows the progression of chronic renal disease. If daily protein intake is less than 0.5-0.6 g/kgbw, the diet has to be supplemented with essential aminoacids/ketoacids. In this study the authors evaluate the long-term effect of low-protein diet supplemented with ketoacids on the progression of chronic renal failure, calcium and phosphorus metabolism, nutritional status, the compliance of patients and the permanent dietary education for the compliance. 51 predialysis patients have been treated with ketoacids supplemented low-protein diet during 12-57 months (mean treatment period: 26 months). Serum creatinine raised from 349.72+/-78.04 micromol/l to 460.66+/-206.66 micromol/l (27 micromol/l/year or 2.3 micromol/l/month), glomerular filtration rate (GFR) decreased from 21.52+/-7.84 ml/min to 18.22+/-7.76 ml/min (0.83 ml/min/year or 0.07 ml/min/month). The slope of 1/serum creatinine versus time was 0.0018 by linear regression analysis. Serum parathormon decreased significantly, but serum calcium and phosphorus did not change. Nutritional status of patients did not change significantly during the follow-up period. Protein intake decreased significantly and remained at this lower level during the treatment period. According to results: low-protein diet supplemented with ketoacids was effective in slowing progression of chronic renal failure, decreased PTH, did not change nutritional status. With permanently and good education it was possible to keep patients on low-protein diet for a long period. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/19158020/[The_effect_of_low_protein_diet_supplemented_with_ketoacids_in_patients_with_chronic_renal_failure]_ L2 - https://akjournals.com/doi/10.1556/OH.2009.28540 DB - PRIME DP - Unbound Medicine ER -