Tags

Type your tag names separated by a space and hit enter

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.

Abstract

Caffeine stimulates central nervous system on a short term. However, the long-term impact of caffeine on cognition remains unclear. We aimed to study the association between coffee and/or tea consumption at midlife and dementia/Alzheimer's disease (AD) risk in late-life. Participants of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study were randomly selected from the survivors of a population-based cohorts previously surveyed within the North Karelia Project and the FINMONICA study in 1972, 1977, 1982 or 1987 (midlife visit). After an average follow-up of 21 years, 1409 individuals (71%) aged 65 to 79 completed the re-examination in 1998. A total of 61 cases were identified as demented (48 with AD). Coffee drinkers at midlife had lower risk of dementia and AD later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, apolipoprotein E epsilon4 allele and depressive symptoms. The lowest risk (65% decreased) was found in people who drank 3-5 cups per day. Tea drinking was relatively uncommon and was not associated with dementia/AD. Coffee drinking at midlife is associated with a decreased risk of dementia/AD later in life. This finding might open possibilities for prevention of dementia/AD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, University of Kuopio, P.O. Kuopio, Finland. Marjo.Eskelinen@uku.fi

    , , ,

    Source

    MeSH

    Aged
    Apolipoproteins E
    Coffee
    Cognition
    Data Interpretation, Statistical
    Dementia
    Diet
    Female
    Humans
    Male
    Middle Aged
    Neuropsychological Tests
    Population
    Risk
    Risk Factors
    Smoking
    Tea

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19158424

    Citation

    Eskelinen, Marjo H., et al. "Midlife Coffee and Tea Drinking and the Risk of Late-life Dementia: a Population-based CAIDE Study." Journal of Alzheimer's Disease : JAD, vol. 16, no. 1, 2009, pp. 85-91.
    Eskelinen MH, Ngandu T, Tuomilehto J, et al. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis. 2009;16(1):85-91.
    Eskelinen, M. H., Ngandu, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009). Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. Journal of Alzheimer's Disease : JAD, 16(1), pp. 85-91. doi:10.3233/JAD-2009-0920.
    Eskelinen MH, et al. Midlife Coffee and Tea Drinking and the Risk of Late-life Dementia: a Population-based CAIDE Study. J Alzheimers Dis. 2009;16(1):85-91. PubMed PMID: 19158424.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. AU - Eskelinen,Marjo H, AU - Ngandu,Tiia, AU - Tuomilehto,Jaakko, AU - Soininen,Hilkka, AU - Kivipelto,Miia, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/3/28/medline SP - 85 EP - 91 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 16 IS - 1 N2 - Caffeine stimulates central nervous system on a short term. However, the long-term impact of caffeine on cognition remains unclear. We aimed to study the association between coffee and/or tea consumption at midlife and dementia/Alzheimer's disease (AD) risk in late-life. Participants of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study were randomly selected from the survivors of a population-based cohorts previously surveyed within the North Karelia Project and the FINMONICA study in 1972, 1977, 1982 or 1987 (midlife visit). After an average follow-up of 21 years, 1409 individuals (71%) aged 65 to 79 completed the re-examination in 1998. A total of 61 cases were identified as demented (48 with AD). Coffee drinkers at midlife had lower risk of dementia and AD later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, apolipoprotein E epsilon4 allele and depressive symptoms. The lowest risk (65% decreased) was found in people who drank 3-5 cups per day. Tea drinking was relatively uncommon and was not associated with dementia/AD. Coffee drinking at midlife is associated with a decreased risk of dementia/AD later in life. This finding might open possibilities for prevention of dementia/AD. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/19158424/Midlife_coffee_and_tea_drinking_and_the_risk_of_late_life_dementia:_a_population_based_CAIDE_study_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=16&issue=1&spage=85 DB - PRIME DP - Unbound Medicine ER -