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Psychotic symptoms in Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: evidence for an association.
J Alzheimers Dis. 2009; 16(1):173-80.JA

Abstract

The occurrence of psychotic symptoms is common in Alzheimer's disease (AD), configuring a possibly distinguished clinical entity defined "Psychosis in Alzheimer's Disease" (AD-P). In order to investigate demographic clinical and biological variables potentially associated to the occurrence of AD-P, 148 AD patients were selected. Mini-Mental State Examination (MMSE), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scores, socio-economic status and 5-HTTLPR and APOE gene polymorphisms were determined for each subject. AD-P patients were significantly more frequent carriers of the long (L) allele of 5-HTTLPR. The percentage of AD-P increased with the number of copies of the L-allele: 13% among S homozygote; 36% among heterozygotes; 51% among L-homozygotes. No difference resulted between AD-P and non-psychotic AD (AD-NP) in the distribution of the epsilon4 allele of APOE. The risk of AD-P was increased in L/L homozygous (OR = 7.25, p = 0.003) and, to a lesser extent, in heterozygous (OR = 3.91; p = 0.018). Backward logistic regression analysis showed that the risk for AD-P was increased in older subjects (OR = 1.07; p = 0.018) while an increase of MMSE score was protective (OR = 0.90; p = 0.004). The occurrence of AD-P resulted significantly related to age at examination, cognitive status, and to the presence of the 5-HTTLPR L-allele.

Authors+Show Affiliations

Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19158433

Citation

Quaranta, Davide, et al. "Psychotic Symptoms in Alzheimer's Disease and 5-HTTLPR Polymorphism of the Serotonin Transporter Gene: Evidence for an Association." Journal of Alzheimer's Disease : JAD, vol. 16, no. 1, 2009, pp. 173-80.
Quaranta D, Bizzarro A, Marra C, et al. Psychotic symptoms in Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: evidence for an association. J Alzheimers Dis. 2009;16(1):173-80.
Quaranta, D., Bizzarro, A., Marra, C., Vita, M. G., Seripa, D., Pilotto, A., Sebastiani, V., Mecocci, P., & Masullo, C. (2009). Psychotic symptoms in Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: evidence for an association. Journal of Alzheimer's Disease : JAD, 16(1), 173-80. https://doi.org/10.3233/JAD-2009-0950
Quaranta D, et al. Psychotic Symptoms in Alzheimer's Disease and 5-HTTLPR Polymorphism of the Serotonin Transporter Gene: Evidence for an Association. J Alzheimers Dis. 2009;16(1):173-80. PubMed PMID: 19158433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychotic symptoms in Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: evidence for an association. AU - Quaranta,Davide, AU - Bizzarro,Alessandra, AU - Marra,Camillo, AU - Vita,Maria Gabriella, AU - Seripa,Davide, AU - Pilotto,Alberto, AU - Sebastiani,Valeria, AU - Mecocci,Patrizia, AU - Masullo,Carlo, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/3/28/medline SP - 173 EP - 80 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 16 IS - 1 N2 - The occurrence of psychotic symptoms is common in Alzheimer's disease (AD), configuring a possibly distinguished clinical entity defined "Psychosis in Alzheimer's Disease" (AD-P). In order to investigate demographic clinical and biological variables potentially associated to the occurrence of AD-P, 148 AD patients were selected. Mini-Mental State Examination (MMSE), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scores, socio-economic status and 5-HTTLPR and APOE gene polymorphisms were determined for each subject. AD-P patients were significantly more frequent carriers of the long (L) allele of 5-HTTLPR. The percentage of AD-P increased with the number of copies of the L-allele: 13% among S homozygote; 36% among heterozygotes; 51% among L-homozygotes. No difference resulted between AD-P and non-psychotic AD (AD-NP) in the distribution of the epsilon4 allele of APOE. The risk of AD-P was increased in L/L homozygous (OR = 7.25, p = 0.003) and, to a lesser extent, in heterozygous (OR = 3.91; p = 0.018). Backward logistic regression analysis showed that the risk for AD-P was increased in older subjects (OR = 1.07; p = 0.018) while an increase of MMSE score was protective (OR = 0.90; p = 0.004). The occurrence of AD-P resulted significantly related to age at examination, cognitive status, and to the presence of the 5-HTTLPR L-allele. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/19158433/Psychotic_symptoms_in_Alzheimer's_disease_and_5_HTTLPR_polymorphism_of_the_serotonin_transporter_gene:_evidence_for_an_association_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=16&issue=1&spage=173 DB - PRIME DP - Unbound Medicine ER -