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Implications of measuring soluble receptor activators of nuclear factor-kappaB ligand and osteoprotegerin in bone metabolism of elderly women.
Gerontology 2009; 55(3):275-80G

Abstract

BACKGROUND/AIM

The discovery of a signaling system consisting of a soluble receptor activator of the NF-kappaB ligand (sRANKL) and its decoy receptor osteoprotegerin (OPG) has provided a valuable key to understanding the pathophysiology of the bone microenvironment. We conducted a cross-sectional study of the role of sRANKL and OPG levels as they relate to bone metabolism in elderly postmenopausal women with and without osteoporosis.

SUBJECTS AND METHODS

Fifty-one elderly women with or without osteoporosis were enrolled in the study. Bone alkaline phosphatase, osteocalcin, urinary deoxypyridinoline and urinary type I collagen N-terminal telopeptide (NTx) were measured as bone metabolic markers. Serum levels of OPG and sRANKL were measured by sandwich enzyme-linked immunosorbent assay and the lumbar spine bone mineral density (LSBMD) with dual-energy X-ray absorptiometry. Furthermore, we compared the sRANKL and OPG levels in elderly women with and without vertebral fractures (VFs).

RESULTS

In elderly postmenopausal women, there was a significant positive association between OPG levels and the T score and Z score of LSBMD (r = 0.345 and p = 0.014 for T score; r = 0.438 and p = 0.001 for Z score). sRANKL levels were not significantly correlated with T score, Z score of LSBMD, or any of the four bone metabolic markers. There were no significant differences in the sRANKL levels among the three groups (normal bone mineral density, osteopenia, and osteoporosis), but a trend toward a higher value in the osteoporosis group. The sRANKL/OPG ratio was negatively correlated with the T score and Z score of LSBMD (r = -0.336, p = 0.017; r = -0.384, p = 0.006, respectively), but not with any of the four bone metabolic markers. OPG levels in elderly women with VFs were lower than in those without VFs (p = 0.05). Multiple regression analysis showed that OPG and NTx are contributing factors to bone loss in elderly women (p = 0.014 and 0.012, respectively).

CONCLUSION

The OPG level provides a good predictor of osteoporosis as well as NTx in elderly women; additionally, the findings suggest that OPG might protect elderly women from bone loss or fractures.

Authors+Show Affiliations

Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19158438

Citation

Chiba, Yuko, et al. "Implications of Measuring Soluble Receptor Activators of Nuclear factor-kappaB Ligand and Osteoprotegerin in Bone Metabolism of Elderly Women." Gerontology, vol. 55, no. 3, 2009, pp. 275-80.
Chiba Y, Onouchi T, Ikeda T, et al. Implications of measuring soluble receptor activators of nuclear factor-kappaB ligand and osteoprotegerin in bone metabolism of elderly women. Gerontology. 2009;55(3):275-80.
Chiba, Y., Onouchi, T., Ikeda, T., Adachi, J., Tamura, Y., & Horiuchi, T. (2009). Implications of measuring soluble receptor activators of nuclear factor-kappaB ligand and osteoprotegerin in bone metabolism of elderly women. Gerontology, 55(3), pp. 275-80. doi:10.1159/000196280.
Chiba Y, et al. Implications of Measuring Soluble Receptor Activators of Nuclear factor-kappaB Ligand and Osteoprotegerin in Bone Metabolism of Elderly Women. Gerontology. 2009;55(3):275-80. PubMed PMID: 19158438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implications of measuring soluble receptor activators of nuclear factor-kappaB ligand and osteoprotegerin in bone metabolism of elderly women. AU - Chiba,Yuko, AU - Onouchi,Tsuneko, AU - Ikeda,Toru, AU - Adachi,Junichiro, AU - Tamura,Yoshiaki, AU - Horiuchi,Toshiyuki, Y1 - 2009/01/22/ PY - 2008/02/15/received PY - 2008/06/05/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/7/23/medline SP - 275 EP - 80 JF - Gerontology JO - Gerontology VL - 55 IS - 3 N2 - BACKGROUND/AIM: The discovery of a signaling system consisting of a soluble receptor activator of the NF-kappaB ligand (sRANKL) and its decoy receptor osteoprotegerin (OPG) has provided a valuable key to understanding the pathophysiology of the bone microenvironment. We conducted a cross-sectional study of the role of sRANKL and OPG levels as they relate to bone metabolism in elderly postmenopausal women with and without osteoporosis. SUBJECTS AND METHODS: Fifty-one elderly women with or without osteoporosis were enrolled in the study. Bone alkaline phosphatase, osteocalcin, urinary deoxypyridinoline and urinary type I collagen N-terminal telopeptide (NTx) were measured as bone metabolic markers. Serum levels of OPG and sRANKL were measured by sandwich enzyme-linked immunosorbent assay and the lumbar spine bone mineral density (LSBMD) with dual-energy X-ray absorptiometry. Furthermore, we compared the sRANKL and OPG levels in elderly women with and without vertebral fractures (VFs). RESULTS: In elderly postmenopausal women, there was a significant positive association between OPG levels and the T score and Z score of LSBMD (r = 0.345 and p = 0.014 for T score; r = 0.438 and p = 0.001 for Z score). sRANKL levels were not significantly correlated with T score, Z score of LSBMD, or any of the four bone metabolic markers. There were no significant differences in the sRANKL levels among the three groups (normal bone mineral density, osteopenia, and osteoporosis), but a trend toward a higher value in the osteoporosis group. The sRANKL/OPG ratio was negatively correlated with the T score and Z score of LSBMD (r = -0.336, p = 0.017; r = -0.384, p = 0.006, respectively), but not with any of the four bone metabolic markers. OPG levels in elderly women with VFs were lower than in those without VFs (p = 0.05). Multiple regression analysis showed that OPG and NTx are contributing factors to bone loss in elderly women (p = 0.014 and 0.012, respectively). CONCLUSION: The OPG level provides a good predictor of osteoporosis as well as NTx in elderly women; additionally, the findings suggest that OPG might protect elderly women from bone loss or fractures. SN - 1423-0003 UR - https://www.unboundmedicine.com/medline/citation/19158438/Implications_of_measuring_soluble_receptor_activators_of_nuclear_factor_kappaB_ligand_and_osteoprotegerin_in_bone_metabolism_of_elderly_women_ L2 - https://www.karger.com?DOI=10.1159/000196280 DB - PRIME DP - Unbound Medicine ER -