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Implications of measuring soluble receptor activators of nuclear factor-kappaB ligand and osteoprotegerin in bone metabolism of elderly women.

Abstract

BACKGROUND/AIM

The discovery of a signaling system consisting of a soluble receptor activator of the NF-kappaB ligand (sRANKL) and its decoy receptor osteoprotegerin (OPG) has provided a valuable key to understanding the pathophysiology of the bone microenvironment. We conducted a cross-sectional study of the role of sRANKL and OPG levels as they relate to bone metabolism in elderly postmenopausal women with and without osteoporosis.

SUBJECTS AND METHODS

Fifty-one elderly women with or without osteoporosis were enrolled in the study. Bone alkaline phosphatase, osteocalcin, urinary deoxypyridinoline and urinary type I collagen N-terminal telopeptide (NTx) were measured as bone metabolic markers. Serum levels of OPG and sRANKL were measured by sandwich enzyme-linked immunosorbent assay and the lumbar spine bone mineral density (LSBMD) with dual-energy X-ray absorptiometry. Furthermore, we compared the sRANKL and OPG levels in elderly women with and without vertebral fractures (VFs).

RESULTS

In elderly postmenopausal women, there was a significant positive association between OPG levels and the T score and Z score of LSBMD (r = 0.345 and p = 0.014 for T score; r = 0.438 and p = 0.001 for Z score). sRANKL levels were not significantly correlated with T score, Z score of LSBMD, or any of the four bone metabolic markers. There were no significant differences in the sRANKL levels among the three groups (normal bone mineral density, osteopenia, and osteoporosis), but a trend toward a higher value in the osteoporosis group. The sRANKL/OPG ratio was negatively correlated with the T score and Z score of LSBMD (r = -0.336, p = 0.017; r = -0.384, p = 0.006, respectively), but not with any of the four bone metabolic markers. OPG levels in elderly women with VFs were lower than in those without VFs (p = 0.05). Multiple regression analysis showed that OPG and NTx are contributing factors to bone loss in elderly women (p = 0.014 and 0.012, respectively).

CONCLUSION

The OPG level provides a good predictor of osteoporosis as well as NTx in elderly women; additionally, the findings suggest that OPG might protect elderly women from bone loss or fractures.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

    , , , ,

    Source

    Gerontology 55:3 2009 pg 275-80

    MeSH

    Absorptiometry, Photon
    Aged
    Aged, 80 and over
    Aging
    Analysis of Variance
    Biomarkers
    Bone Density
    Bone and Bones
    Collagen Type I
    Cross-Sectional Studies
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Lumbar Vertebrae
    Osteoporosis
    Osteoprotegerin
    Peptides
    Postmenopause
    RANK Ligand
    Receptor Activator of Nuclear Factor-kappa B

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19158438

    Citation

    TY - JOUR T1 - Implications of measuring soluble receptor activators of nuclear factor-kappaB ligand and osteoprotegerin in bone metabolism of elderly women. AU - Chiba,Yuko, AU - Onouchi,Tsuneko, AU - Ikeda,Toru, AU - Adachi,Junichiro, AU - Tamura,Yoshiaki, AU - Horiuchi,Toshiyuki, Y1 - 2009/01/22/ PY - 2008/02/15/received PY - 2008/06/05/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/7/23/medline SP - 275 EP - 80 JF - Gerontology JO - Gerontology VL - 55 IS - 3 N2 - BACKGROUND/AIM: The discovery of a signaling system consisting of a soluble receptor activator of the NF-kappaB ligand (sRANKL) and its decoy receptor osteoprotegerin (OPG) has provided a valuable key to understanding the pathophysiology of the bone microenvironment. We conducted a cross-sectional study of the role of sRANKL and OPG levels as they relate to bone metabolism in elderly postmenopausal women with and without osteoporosis. SUBJECTS AND METHODS: Fifty-one elderly women with or without osteoporosis were enrolled in the study. Bone alkaline phosphatase, osteocalcin, urinary deoxypyridinoline and urinary type I collagen N-terminal telopeptide (NTx) were measured as bone metabolic markers. Serum levels of OPG and sRANKL were measured by sandwich enzyme-linked immunosorbent assay and the lumbar spine bone mineral density (LSBMD) with dual-energy X-ray absorptiometry. Furthermore, we compared the sRANKL and OPG levels in elderly women with and without vertebral fractures (VFs). RESULTS: In elderly postmenopausal women, there was a significant positive association between OPG levels and the T score and Z score of LSBMD (r = 0.345 and p = 0.014 for T score; r = 0.438 and p = 0.001 for Z score). sRANKL levels were not significantly correlated with T score, Z score of LSBMD, or any of the four bone metabolic markers. There were no significant differences in the sRANKL levels among the three groups (normal bone mineral density, osteopenia, and osteoporosis), but a trend toward a higher value in the osteoporosis group. The sRANKL/OPG ratio was negatively correlated with the T score and Z score of LSBMD (r = -0.336, p = 0.017; r = -0.384, p = 0.006, respectively), but not with any of the four bone metabolic markers. OPG levels in elderly women with VFs were lower than in those without VFs (p = 0.05). Multiple regression analysis showed that OPG and NTx are contributing factors to bone loss in elderly women (p = 0.014 and 0.012, respectively). CONCLUSION: The OPG level provides a good predictor of osteoporosis as well as NTx in elderly women; additionally, the findings suggest that OPG might protect elderly women from bone loss or fractures. SN - 1423-0003 UR - https://www.unboundmedicine.com/medline/citation/19158438/Implications_of_measuring_soluble_receptor_activators_of_nuclear_factor_kappaB_ligand_and_osteoprotegerin_in_bone_metabolism_of_elderly_women_ L2 - https://www.karger.com?DOI=10.1159/000196280 ER -