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Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians.

Abstract

The association of cognitive impairment with abnormal levels of serum lipid/lipoprotein in the elderly, in whom there are differences between the old aged 65-84 years and the oldest old aged 85 years or above, has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population. In the present study, we observed an association of cognitive impairment with abnormal levels of serum lipid/lipoprotein among very old people using a Chinese cohort aged 90-108 years. The population included 709 unrelated Chinese nonagenarians and centenarians (67.8% women, mean age 93.8 years). The mean score of cognitive function (measured with the 30-item Mini-Mental State Examination, MMSE) was 14.9 (SD 6.0). Comparing abnormal with normal levels of serum lipid/lipoprotein (including triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein), in both genders, the odds ratio of cognitive impairment was statistically insignificant. There were no significant differences in levels of lipid/lipoprotein between subjects with and without cognitive impairment. Pearson correlation showed that MMSE scores were not significantly correlated with levels of lipid/lipoprotein. In summary, we found that levels of serum lipid/lipoprotein were not directly correlated with cognitive impairment among Chinese nonagenarians and centenarians.

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  • Authors+Show Affiliations

    ,

    Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

    , , , , ,

    Source

    MeSH

    Aged, 80 and over
    China
    Cognition
    Cognition Disorders
    Cohort Studies
    Female
    Humans
    Lipids
    Lipoproteins
    Male
    Neuropsychological Tests
    Risk Assessment

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19158441

    Citation

    Huang, Chang-Quan, et al. "Association of Cognitive Impairment With Serum Lipid/lipoprotein Among Chinese Nonagenarians and Centenarians." Dementia and Geriatric Cognitive Disorders, vol. 27, no. 2, 2009, pp. 111-6.
    Huang CQ, Dong BR, Wu HM, et al. Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. Dement Geriatr Cogn Disord. 2009;27(2):111-6.
    Huang, C. Q., Dong, B. R., Wu, H. M., Zhang, Y. L., Wu, J. H., Lu, Z. C., & Flaherty, J. H. (2009). Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. Dementia and Geriatric Cognitive Disorders, 27(2), pp. 111-6. doi:10.1159/000194660.
    Huang CQ, et al. Association of Cognitive Impairment With Serum Lipid/lipoprotein Among Chinese Nonagenarians and Centenarians. Dement Geriatr Cogn Disord. 2009;27(2):111-6. PubMed PMID: 19158441.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. AU - Huang,Chang-Quan, AU - Dong,Bi-Rong, AU - Wu,Hong-Mei, AU - Zhang,Yan-Ling, AU - Wu,Jin-Hui, AU - Lu,Zhen-Chan, AU - Flaherty,Joseph H, Y1 - 2009/01/22/ PY - 2008/09/25/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/5/29/medline SP - 111 EP - 6 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 27 IS - 2 N2 - The association of cognitive impairment with abnormal levels of serum lipid/lipoprotein in the elderly, in whom there are differences between the old aged 65-84 years and the oldest old aged 85 years or above, has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population. In the present study, we observed an association of cognitive impairment with abnormal levels of serum lipid/lipoprotein among very old people using a Chinese cohort aged 90-108 years. The population included 709 unrelated Chinese nonagenarians and centenarians (67.8% women, mean age 93.8 years). The mean score of cognitive function (measured with the 30-item Mini-Mental State Examination, MMSE) was 14.9 (SD 6.0). Comparing abnormal with normal levels of serum lipid/lipoprotein (including triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein), in both genders, the odds ratio of cognitive impairment was statistically insignificant. There were no significant differences in levels of lipid/lipoprotein between subjects with and without cognitive impairment. Pearson correlation showed that MMSE scores were not significantly correlated with levels of lipid/lipoprotein. In summary, we found that levels of serum lipid/lipoprotein were not directly correlated with cognitive impairment among Chinese nonagenarians and centenarians. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19158441/Association_of_cognitive_impairment_with_serum_lipid/lipoprotein_among_Chinese_nonagenarians_and_centenarians_ L2 - https://www.karger.com?DOI=10.1159/000194660 DB - PRIME DP - Unbound Medicine ER -