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Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians.
Dement Geriatr Cogn Disord 2009; 27(2):111-6DG

Abstract

The association of cognitive impairment with abnormal levels of serum lipid/lipoprotein in the elderly, in whom there are differences between the old aged 65-84 years and the oldest old aged 85 years or above, has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population. In the present study, we observed an association of cognitive impairment with abnormal levels of serum lipid/lipoprotein among very old people using a Chinese cohort aged 90-108 years. The population included 709 unrelated Chinese nonagenarians and centenarians (67.8% women, mean age 93.8 years). The mean score of cognitive function (measured with the 30-item Mini-Mental State Examination, MMSE) was 14.9 (SD 6.0). Comparing abnormal with normal levels of serum lipid/lipoprotein (including triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein), in both genders, the odds ratio of cognitive impairment was statistically insignificant. There were no significant differences in levels of lipid/lipoprotein between subjects with and without cognitive impairment. Pearson correlation showed that MMSE scores were not significantly correlated with levels of lipid/lipoprotein. In summary, we found that levels of serum lipid/lipoprotein were not directly correlated with cognitive impairment among Chinese nonagenarians and centenarians.

Authors+Show Affiliations

Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19158441

Citation

Huang, Chang-Quan, et al. "Association of Cognitive Impairment With Serum Lipid/lipoprotein Among Chinese Nonagenarians and Centenarians." Dementia and Geriatric Cognitive Disorders, vol. 27, no. 2, 2009, pp. 111-6.
Huang CQ, Dong BR, Wu HM, et al. Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. Dement Geriatr Cogn Disord. 2009;27(2):111-6.
Huang, C. Q., Dong, B. R., Wu, H. M., Zhang, Y. L., Wu, J. H., Lu, Z. C., & Flaherty, J. H. (2009). Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. Dementia and Geriatric Cognitive Disorders, 27(2), pp. 111-6. doi:10.1159/000194660.
Huang CQ, et al. Association of Cognitive Impairment With Serum Lipid/lipoprotein Among Chinese Nonagenarians and Centenarians. Dement Geriatr Cogn Disord. 2009;27(2):111-6. PubMed PMID: 19158441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. AU - Huang,Chang-Quan, AU - Dong,Bi-Rong, AU - Wu,Hong-Mei, AU - Zhang,Yan-Ling, AU - Wu,Jin-Hui, AU - Lu,Zhen-Chan, AU - Flaherty,Joseph H, Y1 - 2009/01/22/ PY - 2008/09/25/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/5/29/medline SP - 111 EP - 6 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 27 IS - 2 N2 - The association of cognitive impairment with abnormal levels of serum lipid/lipoprotein in the elderly, in whom there are differences between the old aged 65-84 years and the oldest old aged 85 years or above, has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population. In the present study, we observed an association of cognitive impairment with abnormal levels of serum lipid/lipoprotein among very old people using a Chinese cohort aged 90-108 years. The population included 709 unrelated Chinese nonagenarians and centenarians (67.8% women, mean age 93.8 years). The mean score of cognitive function (measured with the 30-item Mini-Mental State Examination, MMSE) was 14.9 (SD 6.0). Comparing abnormal with normal levels of serum lipid/lipoprotein (including triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein), in both genders, the odds ratio of cognitive impairment was statistically insignificant. There were no significant differences in levels of lipid/lipoprotein between subjects with and without cognitive impairment. Pearson correlation showed that MMSE scores were not significantly correlated with levels of lipid/lipoprotein. In summary, we found that levels of serum lipid/lipoprotein were not directly correlated with cognitive impairment among Chinese nonagenarians and centenarians. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19158441/Association_of_cognitive_impairment_with_serum_lipid/lipoprotein_among_Chinese_nonagenarians_and_centenarians_ L2 - https://www.karger.com?DOI=10.1159/000194660 DB - PRIME DP - Unbound Medicine ER -