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Prospective study on the safety and efficacy of combined conjunctival rotational autograft with intraoperative 0.02% mitomycin C in primary pterygium excision.
Cornea. 2009 Feb; 28(2):166-9.C

Abstract

PURPOSE

To describe the novel use of combined conjunctival rotational autograft (CRA) and intraoperative 0.02% mitomycin C (MMC) in the treatment of primary pterygium and to evaluate its safety and efficacy.

METHODS

Prospective interventional case series comparing with historical controls was conducted. Patients with primary pterygium underwent pterygium excision, MMC was applied to the scleral bed after the surface conjunctiva was harvested, and the CRA was sutured back with a 180-degree rotation. Patients were followed for a minimum of 1 year.

RESULTS

Sixty-seven eyes from 67 patients participated in the study, of which 31 (46.3%) were men and 36 (53.7%) were women. The mean age was 58 +/- 10.6 years, (range 36-79 years). There were 2 recurrences (3%), one occurring at month 3 and the other at month 9. Compared with historical controls, CRA-MMC resulted in significantly fewer recurrences than MMC alone (P = 0.005) when adjusted for age and was equally effective when compared with limbal-conjunctival autografts. The main postoperative problem was graft injection, which was noted in 41 eyes (61%) at 1 year.

CONCLUSIONS

To the best of our knowledge, this was the first study on the combined use of CRA and MMC in the treatment of primary pterygium. CRA with MMC was found to be effective in the prevention of recurrence. Although injection remained as a cosmetic concern, it was a safe alternative to limbal-conjunctival autograft in cases where mobilizing autologous conjunctival tissue would not be feasible.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. youngla@ha.org.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19158559

Citation

Young, Alvin L., et al. "Prospective Study On the Safety and Efficacy of Combined Conjunctival Rotational Autograft With Intraoperative 0.02% Mitomycin C in Primary Pterygium Excision." Cornea, vol. 28, no. 2, 2009, pp. 166-9.
Young AL, Tam PM, Leung GY, et al. Prospective study on the safety and efficacy of combined conjunctival rotational autograft with intraoperative 0.02% mitomycin C in primary pterygium excision. Cornea. 2009;28(2):166-9.
Young, A. L., Tam, P. M., Leung, G. Y., Cheng, L. L., Lam, P. T., & Lam, D. S. (2009). Prospective study on the safety and efficacy of combined conjunctival rotational autograft with intraoperative 0.02% mitomycin C in primary pterygium excision. Cornea, 28(2), 166-9. https://doi.org/10.1097/ICO.0b013e318187544d
Young AL, et al. Prospective Study On the Safety and Efficacy of Combined Conjunctival Rotational Autograft With Intraoperative 0.02% Mitomycin C in Primary Pterygium Excision. Cornea. 2009;28(2):166-9. PubMed PMID: 19158559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study on the safety and efficacy of combined conjunctival rotational autograft with intraoperative 0.02% mitomycin C in primary pterygium excision. AU - Young,Alvin L, AU - Tam,Patrick M K, AU - Leung,Gloria Y S, AU - Cheng,Lulu L, AU - Lam,Philip T H, AU - Lam,Dennis S C, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/5/6/medline SP - 166 EP - 9 JF - Cornea JO - Cornea VL - 28 IS - 2 N2 - PURPOSE: To describe the novel use of combined conjunctival rotational autograft (CRA) and intraoperative 0.02% mitomycin C (MMC) in the treatment of primary pterygium and to evaluate its safety and efficacy. METHODS: Prospective interventional case series comparing with historical controls was conducted. Patients with primary pterygium underwent pterygium excision, MMC was applied to the scleral bed after the surface conjunctiva was harvested, and the CRA was sutured back with a 180-degree rotation. Patients were followed for a minimum of 1 year. RESULTS: Sixty-seven eyes from 67 patients participated in the study, of which 31 (46.3%) were men and 36 (53.7%) were women. The mean age was 58 +/- 10.6 years, (range 36-79 years). There were 2 recurrences (3%), one occurring at month 3 and the other at month 9. Compared with historical controls, CRA-MMC resulted in significantly fewer recurrences than MMC alone (P = 0.005) when adjusted for age and was equally effective when compared with limbal-conjunctival autografts. The main postoperative problem was graft injection, which was noted in 41 eyes (61%) at 1 year. CONCLUSIONS: To the best of our knowledge, this was the first study on the combined use of CRA and MMC in the treatment of primary pterygium. CRA with MMC was found to be effective in the prevention of recurrence. Although injection remained as a cosmetic concern, it was a safe alternative to limbal-conjunctival autograft in cases where mobilizing autologous conjunctival tissue would not be feasible. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/19158559/Prospective_study_on_the_safety_and_efficacy_of_combined_conjunctival_rotational_autograft_with_intraoperative_0_02_mitomycin_C_in_primary_pterygium_excision_ L2 - https://doi.org/10.1097/ICO.0b013e318187544d DB - PRIME DP - Unbound Medicine ER -