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[Effects of Shen-song-yang-xin capsule on ventricular arrhythmias in ischemia/reperfusion: experiment with rats].
Zhonghua Yi Xue Za Zhi. 2008 Dec 30; 88(48):3440-3.ZY

Abstract

OBJECTIVE

To investigate the effects of Shen-song-yang-xin capsule containing ginseng, ophiopogon root, red sage root, etc, on the ventricular arrhythmias caused by ischemic/reperfusion.

METHODS

Thirty SD rats were randomly divided into 2 equal groups: Shen-song-yang-xin group undergoing gastric infusion of Shen-song-yang-xin 4 g x kg(-1) x d(-1) for 2 weeks and then subjected to left coronary artery occlusion for 30 minutes followed by reperfusion for 60 minutes, and control group undergoing ischemia/reperfusion only. Electrocardiography was conducted to record the ventricular arrhythmias, and after 60 minutes of reperfusion the rats were killed with their hearts removed to measure the infarction size.

RESULTS

(1) During the 30 minutes' ischemia, the average number of episode of ischemia-induced premature ventricular contraction of the Shen-song-yang-xin group was (6.7 +/- 0.3) beats/30 min, significantly lower than that of the control group [(15.0 +/- 1.1) beats/30 min, P = 0.007]; the average number of episode of ischemia-induced ventricular tachycardia of the Shen-song-yang-xin group was (3.5 +/- 0.2) episodes/30 min, significantly lower than that of the control group [(14.7 +/- 0.6) episodes/30 min, P = 0.003]; the duration of ventricular tachycardia of the Shen-song-yang-xin group was (10.3 +/- 2.0) s, significantly shorter than that of the control group [(28.3 +/- 4.6) s, P = 0.018]; and the duration of ventricular fibrillation of the Shen-song-yang-xin group was (7.0 +/- 1.1) s, significantly shorter than that of the control group [(15.0 +/- 1.7) s, P = 0.031]. (2) 60 minutes after the reperfusion, the number of episode of premature ventricular contraction of the Shen-song-yang-xin group was (5.3 +/- 0.8) beats/60 min, significantly lower than that of the control group [(15.6 +/- 1.8) beats/60 min, P = 0.002], and the duration of reperfusion-induced ventricular tachycardia was (4.6 +/- 0.5) s, significantly shorter than that of the control group [(13.5 +/- 0.6) s, P = 0.001].

CONCLUSION

Shen-song-yang-xin capsule significantly reduces the ischemia-induced ventricular arrhythmia, average episode number of reperfusion-induced premature ventricular contraction, and duration of reperfusion-induced ventricular tachycardia.

Links

Publisher Full Text

Authors+Show Affiliations

Ren JY
Department of Cardiology, Peking University People's Hospital, Beijing 100044, China.
Li LJ
No affiliation info available
Wang RJ
No affiliation info available
Chen H
No affiliation info available
Wu YL
No affiliation info available
Luo Y
No affiliation info available

MeSH

AnimalsArrhythmias, CardiacDisease Models, AnimalDrugs, Chinese HerbalMaleMyocardial Reperfusion InjuryPhytotherapyRatsRats, Sprague-Dawley

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19159580

Citation

Ren, Jing-yi, et al. "[Effects of Shen-song-yang-xin Capsule On Ventricular Arrhythmias in Ischemia/reperfusion: Experiment With Rats]." Zhonghua Yi Xue Za Zhi, vol. 88, no. 48, 2008, pp. 3440-3.
Ren JY, Li LJ, Wang RJ, et al. [Effects of Shen-song-yang-xin capsule on ventricular arrhythmias in ischemia/reperfusion: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008;88(48):3440-3.
Ren, J. Y., Li, L. J., Wang, R. J., Chen, H., Wu, Y. L., & Luo, Y. (2008). [Effects of Shen-song-yang-xin capsule on ventricular arrhythmias in ischemia/reperfusion: experiment with rats]. Zhonghua Yi Xue Za Zhi, 88(48), 3440-3.
Ren JY, et al. [Effects of Shen-song-yang-xin Capsule On Ventricular Arrhythmias in Ischemia/reperfusion: Experiment With Rats]. Zhonghua Yi Xue Za Zhi. 2008 Dec 30;88(48):3440-3. PubMed PMID: 19159580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of Shen-song-yang-xin capsule on ventricular arrhythmias in ischemia/reperfusion: experiment with rats]. AU - Ren,Jing-yi, AU - Li,Li-jun, AU - Wang,Ruo-jie, AU - Chen,Hong, AU - Wu,Yi-ling, AU - Luo,Yu, PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/6/12/medline SP - 3440 EP - 3 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 88 IS - 48 N2 - OBJECTIVE: To investigate the effects of Shen-song-yang-xin capsule containing ginseng, ophiopogon root, red sage root, etc, on the ventricular arrhythmias caused by ischemic/reperfusion. METHODS: Thirty SD rats were randomly divided into 2 equal groups: Shen-song-yang-xin group undergoing gastric infusion of Shen-song-yang-xin 4 g x kg(-1) x d(-1) for 2 weeks and then subjected to left coronary artery occlusion for 30 minutes followed by reperfusion for 60 minutes, and control group undergoing ischemia/reperfusion only. Electrocardiography was conducted to record the ventricular arrhythmias, and after 60 minutes of reperfusion the rats were killed with their hearts removed to measure the infarction size. RESULTS: (1) During the 30 minutes' ischemia, the average number of episode of ischemia-induced premature ventricular contraction of the Shen-song-yang-xin group was (6.7 +/- 0.3) beats/30 min, significantly lower than that of the control group [(15.0 +/- 1.1) beats/30 min, P = 0.007]; the average number of episode of ischemia-induced ventricular tachycardia of the Shen-song-yang-xin group was (3.5 +/- 0.2) episodes/30 min, significantly lower than that of the control group [(14.7 +/- 0.6) episodes/30 min, P = 0.003]; the duration of ventricular tachycardia of the Shen-song-yang-xin group was (10.3 +/- 2.0) s, significantly shorter than that of the control group [(28.3 +/- 4.6) s, P = 0.018]; and the duration of ventricular fibrillation of the Shen-song-yang-xin group was (7.0 +/- 1.1) s, significantly shorter than that of the control group [(15.0 +/- 1.7) s, P = 0.031]. (2) 60 minutes after the reperfusion, the number of episode of premature ventricular contraction of the Shen-song-yang-xin group was (5.3 +/- 0.8) beats/60 min, significantly lower than that of the control group [(15.6 +/- 1.8) beats/60 min, P = 0.002], and the duration of reperfusion-induced ventricular tachycardia was (4.6 +/- 0.5) s, significantly shorter than that of the control group [(13.5 +/- 0.6) s, P = 0.001]. CONCLUSION: Shen-song-yang-xin capsule significantly reduces the ischemia-induced ventricular arrhythmia, average episode number of reperfusion-induced premature ventricular contraction, and duration of reperfusion-induced ventricular tachycardia. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/19159580/[Effects_of_Shen_song_yang_xin_capsule_on_ventricular_arrhythmias_in_ischemia/reperfusion:_experiment_with_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2008&vol=88&issue=48&fpage=3440 DB - PRIME DP - Unbound Medicine ER -