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Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats.
Pharmacol Biochem Behav. 2009 Apr; 92(2):297-303.PB

Abstract

Kava is a widely available and used herbal medicine that is not regulated in many countries. There are many questions concerning kava's stimulus properties, potential for therapeutic use, and potential for abuse. Although there is evidence that kava may possess some anxiolytic properties, kava's mechanism of action and the extent to which it may serve as an alternative to pharmaceutical anxiolytics are not fully known. The current study was designed to evaluate whether kava shares discriminative-stimulus properties with the anxiolytic chlordiazepoxide (CDP). Effects of different doses of kava extract were evaluated in two groups of rats trained to discriminate either a high or low training dose of CDP (i.p.). In order to assess time-course effects, two tests were conducted/session at 60 (Test One) and 90 (Test Two) min following oral administration of kava, CDP, or d-amphetamine. Dose-dependent substitution of CDP was found in both training groups in both tests. Kava (560 mg/kg, p.o.) occasioned responding indicative of partial substitution in both groups during Test One and only the low-dose group during Test Two. Partial substitution of kava extract for CDP suggests that the herbal compound may share a mechanism of action similar to CDP, but is less potent.

Authors+Show Affiliations

West Virginia University, Department of Psychology, P.O. Box 6040, Morgantown, WV 26506, United States.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19159643

Citation

Bruner, Natalie R., and Karen G. Anderson. "Discriminative-stimulus and Time-course Effects of Kava-kava (Piper Methysticum) in Rats." Pharmacology, Biochemistry, and Behavior, vol. 92, no. 2, 2009, pp. 297-303.
Bruner NR, Anderson KG. Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats. Pharmacol Biochem Behav. 2009;92(2):297-303.
Bruner, N. R., & Anderson, K. G. (2009). Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats. Pharmacology, Biochemistry, and Behavior, 92(2), 297-303. https://doi.org/10.1016/j.pbb.2008.12.017
Bruner NR, Anderson KG. Discriminative-stimulus and Time-course Effects of Kava-kava (Piper Methysticum) in Rats. Pharmacol Biochem Behav. 2009;92(2):297-303. PubMed PMID: 19159643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats. AU - Bruner,Natalie R, AU - Anderson,Karen G, Y1 - 2008/12/31/ PY - 2008/09/05/received PY - 2008/12/17/revised PY - 2008/12/18/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/4/28/medline SP - 297 EP - 303 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 92 IS - 2 N2 - Kava is a widely available and used herbal medicine that is not regulated in many countries. There are many questions concerning kava's stimulus properties, potential for therapeutic use, and potential for abuse. Although there is evidence that kava may possess some anxiolytic properties, kava's mechanism of action and the extent to which it may serve as an alternative to pharmaceutical anxiolytics are not fully known. The current study was designed to evaluate whether kava shares discriminative-stimulus properties with the anxiolytic chlordiazepoxide (CDP). Effects of different doses of kava extract were evaluated in two groups of rats trained to discriminate either a high or low training dose of CDP (i.p.). In order to assess time-course effects, two tests were conducted/session at 60 (Test One) and 90 (Test Two) min following oral administration of kava, CDP, or d-amphetamine. Dose-dependent substitution of CDP was found in both training groups in both tests. Kava (560 mg/kg, p.o.) occasioned responding indicative of partial substitution in both groups during Test One and only the low-dose group during Test Two. Partial substitution of kava extract for CDP suggests that the herbal compound may share a mechanism of action similar to CDP, but is less potent. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/19159643/Discriminative_stimulus_and_time_course_effects_of_kava_kava__Piper_methysticum__in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(08)00413-9 DB - PRIME DP - Unbound Medicine ER -