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Enhanced separation of seven quinolones by capillary electrophoresis with silica nanoparticles as additive.
Talanta. 2009 Mar 15; 77(5):1667-74.T

Abstract

This paper describes the enhanced separation of lomefloxacin, sparfloxacin, fleroxacin, norfloxacin, ofloxacin, gatifloxacin and pazufloxacin by capillary zone electrophoresis (CZE) using silica nanoparticles (SiNPs) as running buffer additive. The impact of SiNPs concentration on the resolution and selectivity of separation was investigated and a given value of SiNPs was finally chosen under the optimum conditions. The addition of the SiNPs to the running buffer enabled electroosmotic flow (EOF) decrease and permitted full interaction between SiNPs and analytes. The influence of separation voltage, pH and buffer concentration on the separation in the presence of SiNPs was examined. Interactions between drugs and nanoparticles during the separation are discussed; the determination of interaction constants is also achieved. A good resolution of seven quinolones was obtained within 15 min in a 50 cm effective length fused-silica capillary at a separation voltage of +10 kV in a 12 mM disodium tetraborate-phosphate buffer (pH 9.08) containing 5.2 microgmL(-1) SiNPs.

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Authors+Show Affiliations

Wang Y
College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
Baeyens WR
No affiliation info available
Huang C
No affiliation info available
Fei G
No affiliation info available
He L
No affiliation info available
Ouyang J
No affiliation info available

MeSH

BuffersElectrophoresis, CapillaryFleroxacinFluoroquinolonesGatifloxacinNanoparticlesOfloxacinOxazinesQuinolonesSilicon Dioxide

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19159781

Citation

Wang, Yanqing, et al. "Enhanced Separation of Seven Quinolones By Capillary Electrophoresis With Silica Nanoparticles as Additive." Talanta, vol. 77, no. 5, 2009, pp. 1667-74.
Wang Y, Baeyens WR, Huang C, et al. Enhanced separation of seven quinolones by capillary electrophoresis with silica nanoparticles as additive. Talanta. 2009;77(5):1667-74.
Wang, Y., Baeyens, W. R., Huang, C., Fei, G., He, L., & Ouyang, J. (2009). Enhanced separation of seven quinolones by capillary electrophoresis with silica nanoparticles as additive. Talanta, 77(5), 1667-74. https://doi.org/10.1016/j.talanta.2008.10.002
Wang Y, et al. Enhanced Separation of Seven Quinolones By Capillary Electrophoresis With Silica Nanoparticles as Additive. Talanta. 2009 Mar 15;77(5):1667-74. PubMed PMID: 19159781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced separation of seven quinolones by capillary electrophoresis with silica nanoparticles as additive. AU - Wang,Yanqing, AU - Baeyens,Willy R G, AU - Huang,Changgang, AU - Fei,Guangtao, AU - He,Li, AU - Ouyang,Jin, Y1 - 2008/10/14/ PY - 2008/06/12/received PY - 2008/09/30/revised PY - 2008/10/01/accepted PY - 2009/1/23/entrez PY - 2009/1/23/pubmed PY - 2009/2/28/medline SP - 1667 EP - 74 JF - Talanta JO - Talanta VL - 77 IS - 5 N2 - This paper describes the enhanced separation of lomefloxacin, sparfloxacin, fleroxacin, norfloxacin, ofloxacin, gatifloxacin and pazufloxacin by capillary zone electrophoresis (CZE) using silica nanoparticles (SiNPs) as running buffer additive. The impact of SiNPs concentration on the resolution and selectivity of separation was investigated and a given value of SiNPs was finally chosen under the optimum conditions. The addition of the SiNPs to the running buffer enabled electroosmotic flow (EOF) decrease and permitted full interaction between SiNPs and analytes. The influence of separation voltage, pH and buffer concentration on the separation in the presence of SiNPs was examined. Interactions between drugs and nanoparticles during the separation are discussed; the determination of interaction constants is also achieved. A good resolution of seven quinolones was obtained within 15 min in a 50 cm effective length fused-silica capillary at a separation voltage of +10 kV in a 12 mM disodium tetraborate-phosphate buffer (pH 9.08) containing 5.2 microgmL(-1) SiNPs. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/19159781/Enhanced_separation_of_seven_quinolones_by_capillary_electrophoresis_with_silica_nanoparticles_as_additive_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(08)00724-8 DB - PRIME DP - Unbound Medicine ER -