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Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study.
J Magn Reson Imaging. 2009 Feb; 29(2):268-74.JM

Abstract

PURPOSE

To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH).

MATERIALS AND METHODS

DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score.

RESULTS

ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity.

CONCLUSION

ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings.

Authors+Show Affiliations

Department of Neurology, Medical University of Graz, Austria. stefan.ropele@meduni-graz.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19161174

Citation

Ropele, Stefan, et al. "Quantitation of Brain Tissue Changes Associated With White Matter Hyperintensities By Diffusion-weighted and Magnetization Transfer Imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) Study." Journal of Magnetic Resonance Imaging : JMRI, vol. 29, no. 2, 2009, pp. 268-74.
Ropele S, Seewann A, Gouw AA, et al. Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study. J Magn Reson Imaging. 2009;29(2):268-74.
Ropele, S., Seewann, A., Gouw, A. A., van der Flier, W. M., Schmidt, R., Pantoni, L., Inzitari, D., Erkinjuntti, T., Scheltens, P., Wahlund, L. O., Waldemar, G., Chabriat, H., Ferro, J., Hennerici, M., O'Brien, J., Wallin, A., Langhorne, P., Visser, M. C., Barkhof, F., & Fazekas, F. (2009). Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study. Journal of Magnetic Resonance Imaging : JMRI, 29(2), 268-74. https://doi.org/10.1002/jmri.21580
Ropele S, et al. Quantitation of Brain Tissue Changes Associated With White Matter Hyperintensities By Diffusion-weighted and Magnetization Transfer Imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) Study. J Magn Reson Imaging. 2009;29(2):268-74. PubMed PMID: 19161174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study. AU - Ropele,Stefan, AU - Seewann,Alexandra, AU - Gouw,Alida A, AU - van der Flier,Wiesje M, AU - Schmidt,Reinhold, AU - Pantoni,Leonardo, AU - Inzitari,Domenico, AU - Erkinjuntti,Timo, AU - Scheltens,Philip, AU - Wahlund,Lars O, AU - Waldemar,Gunhild, AU - Chabriat,Hugues, AU - Ferro,José, AU - Hennerici,Michael, AU - O'Brien,John, AU - Wallin,Anders, AU - Langhorne,Peter, AU - Visser,Marieke C, AU - Barkhof,Frederik, AU - Fazekas,Franz, AU - ,, PY - 2009/1/24/entrez PY - 2009/1/24/pubmed PY - 2009/4/1/medline SP - 268 EP - 74 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 29 IS - 2 N2 - PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score. RESULTS: ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity. CONCLUSION: ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/19161174/Quantitation_of_brain_tissue_changes_associated_with_white_matter_hyperintensities_by_diffusion_weighted_and_magnetization_transfer_imaging:_the_LADIS__Leukoaraiosis_and_Disability_in_the_Elderly__study_ L2 - https://doi.org/10.1002/jmri.21580 DB - PRIME DP - Unbound Medicine ER -