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Migraine in the triptan era: lessons from epidemiology, pathophysiology, and clinical science.
Headache 2009; 49 Suppl 1:S21-33H

Abstract

The triptan era has been a time of remarkable progress for migraine diagnosis and treatment. In this paper, we review some of the advances achieved in migraine science during this era focusing on 3 themes: lessons from clinical practice, lessons from epidemiology and lessons from pathophysiology. Science has shown that migraine is a disorder of the brain, and that the key events happen in the the trigeminal neuronal pathways, not on blood vessels. Clinical science has led to the observation that migraine sometimes progresses or remits. This in turn led to longitudinal epidemiologic studies focusing on factors that determine migraine prognosis. In addition, these studies raised questions about the mechanisms of migraine progression, including the role of allodynia, obesity, inflammation, and medications as determinants of progression. This in turn opens a new set of scientific questions about the neurobiologic determinants of migraine, as well as of its clinical course, and exciting opportunities to develop new therapies for this highly disabling brain disorder.

Authors+Show Affiliations

Global Director for Scientific Affairs-Neuroscience; Merck Research Laboratories, Whitehouse Station, NJ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19161562

Citation

Bigal, Marcelo E., et al. "Migraine in the Triptan Era: Lessons From Epidemiology, Pathophysiology, and Clinical Science." Headache, vol. 49 Suppl 1, 2009, pp. S21-33.
Bigal ME, Ferrari M, Silberstein SD, et al. Migraine in the triptan era: lessons from epidemiology, pathophysiology, and clinical science. Headache. 2009;49 Suppl 1:S21-33.
Bigal, M. E., Ferrari, M., Silberstein, S. D., Lipton, R. B., & Goadsby, P. J. (2009). Migraine in the triptan era: lessons from epidemiology, pathophysiology, and clinical science. Headache, 49 Suppl 1, pp. S21-33. doi:10.1111/j.1526-4610.2008.01336.x.
Bigal ME, et al. Migraine in the Triptan Era: Lessons From Epidemiology, Pathophysiology, and Clinical Science. Headache. 2009;49 Suppl 1:S21-33. PubMed PMID: 19161562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Migraine in the triptan era: lessons from epidemiology, pathophysiology, and clinical science. AU - Bigal,Marcelo E, AU - Ferrari,Michel, AU - Silberstein,Stephen D, AU - Lipton,Richard B, AU - Goadsby,Peter J, PY - 2009/1/24/entrez PY - 2009/1/30/pubmed PY - 2009/3/14/medline SP - S21 EP - 33 JF - Headache JO - Headache VL - 49 Suppl 1 N2 - The triptan era has been a time of remarkable progress for migraine diagnosis and treatment. In this paper, we review some of the advances achieved in migraine science during this era focusing on 3 themes: lessons from clinical practice, lessons from epidemiology and lessons from pathophysiology. Science has shown that migraine is a disorder of the brain, and that the key events happen in the the trigeminal neuronal pathways, not on blood vessels. Clinical science has led to the observation that migraine sometimes progresses or remits. This in turn led to longitudinal epidemiologic studies focusing on factors that determine migraine prognosis. In addition, these studies raised questions about the mechanisms of migraine progression, including the role of allodynia, obesity, inflammation, and medications as determinants of progression. This in turn opens a new set of scientific questions about the neurobiologic determinants of migraine, as well as of its clinical course, and exciting opportunities to develop new therapies for this highly disabling brain disorder. SN - 1526-4610 UR - https://www.unboundmedicine.com/medline/citation/19161562/Migraine_in_the_triptan_era:_lessons_from_epidemiology_pathophysiology_and_clinical_science_ L2 - https://doi.org/10.1111/j.1526-4610.2008.01336.x DB - PRIME DP - Unbound Medicine ER -