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Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test.
Behav Brain Res. 2009 Jun 08; 200(1):122-7.BB

Abstract

The opioid system has been implicated in major depression and in the mechanism of action of antidepressants. This study investigated the involvement of the opioid system in the antidepressant-like effect of the water-soluble B-vitamin folic acid in the forced swimming test (FST). The effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist), naltrindole (3 mg/kg, i.p., a selective delta-opioid receptor antagonist), naloxonazine (10 mg/kg, i.p., a selective mu(1)-opioid receptor antagonist, 24 h before), but not with naloxone methiodide (1 mg/kg, s.c., a peripherally acting opioid receptor antagonist). In addition, a sub-effective dose of folic acid (1 nmol/site, i.c.v.) produced a synergistic antidepressant-like effect in the FST with a sub-effective dose of morphine (1 mg/kg, s.c.). A further approach was designed to investigate the possible relationship between the opioid system and NMDA receptors in the mechanism of action of folic acid in the FST. Pretreatment of the animals with naloxone (1 mg/kg, i.p.) prevented the synergistic antidepressant-like effect of folic acid (1 nmol/site, i.c.v.) and MK-801 (0.001 mg/kg, i.p., a non-competitive NMDA receptor antagonist). Together the results firstly indicate that the anti-immobility effect of folic acid in the FST is mediated by an interaction with the opioid system (mu(1) and delta), likely dependent on the inhibition of NMDA receptors elicited by folic acid.

Authors+Show Affiliations

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, 88040-900 Florianópolis, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19162083

Citation

Brocardo, Patrícia S., et al. "Evidence for the Involvement of the Opioid System in the Antidepressant-like Effect of Folic Acid in the Mouse Forced Swimming Test." Behavioural Brain Research, vol. 200, no. 1, 2009, pp. 122-7.
Brocardo PS, Budni J, Lobato KR, et al. Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test. Behav Brain Res. 2009;200(1):122-7.
Brocardo, P. S., Budni, J., Lobato, K. R., Santos, A. R., & Rodrigues, A. L. (2009). Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test. Behavioural Brain Research, 200(1), 122-7. https://doi.org/10.1016/j.bbr.2009.01.004
Brocardo PS, et al. Evidence for the Involvement of the Opioid System in the Antidepressant-like Effect of Folic Acid in the Mouse Forced Swimming Test. Behav Brain Res. 2009 Jun 8;200(1):122-7. PubMed PMID: 19162083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test. AU - Brocardo,Patrícia S, AU - Budni,Josiane, AU - Lobato,Kelly R, AU - Santos,Adair Roberto S, AU - Rodrigues,Ana Lúcia S, Y1 - 2009/01/08/ PY - 2008/08/21/received PY - 2008/12/18/revised PY - 2009/01/05/accepted PY - 2009/1/24/entrez PY - 2009/1/24/pubmed PY - 2009/6/19/medline SP - 122 EP - 7 JF - Behavioural brain research JO - Behav Brain Res VL - 200 IS - 1 N2 - The opioid system has been implicated in major depression and in the mechanism of action of antidepressants. This study investigated the involvement of the opioid system in the antidepressant-like effect of the water-soluble B-vitamin folic acid in the forced swimming test (FST). The effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist), naltrindole (3 mg/kg, i.p., a selective delta-opioid receptor antagonist), naloxonazine (10 mg/kg, i.p., a selective mu(1)-opioid receptor antagonist, 24 h before), but not with naloxone methiodide (1 mg/kg, s.c., a peripherally acting opioid receptor antagonist). In addition, a sub-effective dose of folic acid (1 nmol/site, i.c.v.) produced a synergistic antidepressant-like effect in the FST with a sub-effective dose of morphine (1 mg/kg, s.c.). A further approach was designed to investigate the possible relationship between the opioid system and NMDA receptors in the mechanism of action of folic acid in the FST. Pretreatment of the animals with naloxone (1 mg/kg, i.p.) prevented the synergistic antidepressant-like effect of folic acid (1 nmol/site, i.c.v.) and MK-801 (0.001 mg/kg, i.p., a non-competitive NMDA receptor antagonist). Together the results firstly indicate that the anti-immobility effect of folic acid in the FST is mediated by an interaction with the opioid system (mu(1) and delta), likely dependent on the inhibition of NMDA receptors elicited by folic acid. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19162083/Evidence_for_the_involvement_of_the_opioid_system_in_the_antidepressant_like_effect_of_folic_acid_in_the_mouse_forced_swimming_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00004-7 DB - PRIME DP - Unbound Medicine ER -