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Nevoid Basal cell carcinoma syndrome: a cephalometric study of patients and controls.
J Craniofac Surg. 2009 Jan; 20(1):203-8.JC

Abstract

Craniofacial morphology of patients with nevoid basal cell carcinoma syndrome (NBCCS) has sometimes been reported at clinical examination, but any investigation has described it on the basis of cephalometric measurements.The purpose of this study was to conduct a cephalometric analysis of patients with NBCCS and to compare measurements with non-NBCCS subjects of similar ages, to elucidate if there is any relationship between NBCCS and craniofacial morphology.The study population consisted of 14 adult patients (9 men and 5 women), ranging in age from 18.2 to 56.8 years, with the diagnosis of NBCCS, with good-quality lateral cephalometric radiographs, and 14 adult healthy patients matched for age and sex to the NBCCS group. Cephalometric measurements were carried out on radiographs, and measurements of angles and distances were performed.Statistical differences between NBCCS subjects and controls were observed. Data analysis displayed that the measurements of the anterior cranial base (P <or= 0.0043), mandibular length (P <or= 0.0168), and maxillary length (P <or= 0.0284), posterior facial height (P <or= 0.0406), and of mandibular angle (P <or= 0.0026), facial axis angle (P <or= 0.0402), lower facial height angles (P <or= 0.0135), and of interincisal angulation (P <or= 0.0148) were higher in NBCCS subjects in respect to controls. On the contrary, the facial convexity (P <or= 0.0189) and the mandibular arc angle (P <or= 0.0378) were reduced in NBCCS subjects.According to these findings, NBCCS patients presented a sagittal lengthening of the anterior cranial base and maxilla and a vertically and horizontally overdeveloped mandible, together with the features of a long-face syndrome with a large gonial angle.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, II Dental Unity, University of Catania, Catania, Germany. rleonard@unict.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19165028

Citation

Leonardi, Rosalia, et al. "Nevoid Basal Cell Carcinoma Syndrome: a Cephalometric Study of Patients and Controls." The Journal of Craniofacial Surgery, vol. 20, no. 1, 2009, pp. 203-8.
Leonardi R, Licciardello V, Santarelli A, et al. Nevoid Basal cell carcinoma syndrome: a cephalometric study of patients and controls. J Craniofac Surg. 2009;20(1):203-8.
Leonardi, R., Licciardello, V., Santarelli, A., Ciavarella, D., Bolouri, S., Härle, F., Caltabiano, M., & Lo Muzio, L. (2009). Nevoid Basal cell carcinoma syndrome: a cephalometric study of patients and controls. The Journal of Craniofacial Surgery, 20(1), 203-8. https://doi.org/10.1097/SCS.0b013e318191cf73
Leonardi R, et al. Nevoid Basal Cell Carcinoma Syndrome: a Cephalometric Study of Patients and Controls. J Craniofac Surg. 2009;20(1):203-8. PubMed PMID: 19165028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nevoid Basal cell carcinoma syndrome: a cephalometric study of patients and controls. AU - Leonardi,Rosalia, AU - Licciardello,Valeria, AU - Santarelli,Andrea, AU - Ciavarella,Domenico, AU - Bolouri,Susanne, AU - Härle,Franz, AU - Caltabiano,Mario, AU - Lo Muzio,Lorenzo, PY - 2009/1/24/entrez PY - 2009/1/24/pubmed PY - 2009/5/8/medline SP - 203 EP - 8 JF - The Journal of craniofacial surgery JO - J Craniofac Surg VL - 20 IS - 1 N2 - Craniofacial morphology of patients with nevoid basal cell carcinoma syndrome (NBCCS) has sometimes been reported at clinical examination, but any investigation has described it on the basis of cephalometric measurements.The purpose of this study was to conduct a cephalometric analysis of patients with NBCCS and to compare measurements with non-NBCCS subjects of similar ages, to elucidate if there is any relationship between NBCCS and craniofacial morphology.The study population consisted of 14 adult patients (9 men and 5 women), ranging in age from 18.2 to 56.8 years, with the diagnosis of NBCCS, with good-quality lateral cephalometric radiographs, and 14 adult healthy patients matched for age and sex to the NBCCS group. Cephalometric measurements were carried out on radiographs, and measurements of angles and distances were performed.Statistical differences between NBCCS subjects and controls were observed. Data analysis displayed that the measurements of the anterior cranial base (P <or= 0.0043), mandibular length (P <or= 0.0168), and maxillary length (P <or= 0.0284), posterior facial height (P <or= 0.0406), and of mandibular angle (P <or= 0.0026), facial axis angle (P <or= 0.0402), lower facial height angles (P <or= 0.0135), and of interincisal angulation (P <or= 0.0148) were higher in NBCCS subjects in respect to controls. On the contrary, the facial convexity (P <or= 0.0189) and the mandibular arc angle (P <or= 0.0378) were reduced in NBCCS subjects.According to these findings, NBCCS patients presented a sagittal lengthening of the anterior cranial base and maxilla and a vertically and horizontally overdeveloped mandible, together with the features of a long-face syndrome with a large gonial angle. SN - 1536-3732 UR - https://www.unboundmedicine.com/medline/citation/19165028/Nevoid_Basal_cell_carcinoma_syndrome:_a_cephalometric_study_of_patients_and_controls_ L2 - http://dx.doi.org/10.1097/SCS.0b013e318191cf73 DB - PRIME DP - Unbound Medicine ER -