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Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia.

Abstract

The binocular depth inversion illusion test (BDII) represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. This study explores impairment of visual processing in different major psychiatric diseases investigating 313 subjects, suffering of either an initial prodromal state of psychosis (IPS) or a first-episode, antipsychotic-naïve paranoid schizophrenia (SZ-N) as well as short-term antipsychotically treated schizophrenia (SZ-T), major depression (MDD), bipolar disorder (BD), dementia (D), and healthy controls (HC). Patients suffering from either IPS, SZ-N or a SZ-T showed significantly higher scores of BDII compared to HC, indicating that visual processing is already disturbed at an early state of the disease. For MDD, BD and D no statistically significant difference was found compared to HC. As the identification of individuals at high risk for developing schizophrenia relies on rating scales assessing subtle, pre-psychotic psychopathology, it would be of interest to have more diagnostic criteria available, testing, e.g. cognitive and perceptual impairment. We therefore analysed the receiver operating characteristic (ROC) curve, testing prodromal cases versus a clinically relevant sample of non-psychotic patients and controls, which included HC as well as the groups of patients suffering from MDD, BD or D revealing a AUC of 0.70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia.

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  • Authors+Show Affiliations

    ,

    Dept. of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str. 62, 50924, Cologne, Germany.

    , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Antipsychotic Agents
    Bipolar Disorder
    Dementia
    Depressive Disorder, Major
    Depth Perception
    Female
    Humans
    Male
    Middle Aged
    Neuropsychological Tests
    Photic Stimulation
    Psychiatric Status Rating Scales
    Schizophrenia
    Schizophrenia, Paranoid
    Vision Disparity
    Vision, Binocular

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19165523

    Citation

    Koethe, Dagmar, et al. "Binocular Depth Inversion as a Paradigm of Reduced Visual Information Processing in Prodromal State, Antipsychotic-naïve and Treated Schizophrenia." European Archives of Psychiatry and Clinical Neuroscience, vol. 259, no. 4, 2009, pp. 195-202.
    Koethe D, Kranaster L, Hoyer C, et al. Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2009;259(4):195-202.
    Koethe, D., Kranaster, L., Hoyer, C., Gross, S., Neatby, M. A., Schultze-Lutter, F., ... Leweke, F. M. (2009). Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 259(4), pp. 195-202. doi:10.1007/s00406-008-0851-6.
    Koethe D, et al. Binocular Depth Inversion as a Paradigm of Reduced Visual Information Processing in Prodromal State, Antipsychotic-naïve and Treated Schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2009;259(4):195-202. PubMed PMID: 19165523.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. AU - Koethe,Dagmar, AU - Kranaster,Laura, AU - Hoyer,Carolin, AU - Gross,Sonja, AU - Neatby,Miriam A, AU - Schultze-Lutter,Frauke, AU - Ruhrmann,Stephan, AU - Klosterkötter,Joachim, AU - Hellmich,Martin, AU - Leweke,F Markus, Y1 - 2009/01/22/ PY - 2007/09/05/received PY - 2008/08/29/accepted PY - 2009/1/24/entrez PY - 2009/1/24/pubmed PY - 2009/7/16/medline SP - 195 EP - 202 JF - European archives of psychiatry and clinical neuroscience JO - Eur Arch Psychiatry Clin Neurosci VL - 259 IS - 4 N2 - The binocular depth inversion illusion test (BDII) represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. This study explores impairment of visual processing in different major psychiatric diseases investigating 313 subjects, suffering of either an initial prodromal state of psychosis (IPS) or a first-episode, antipsychotic-naïve paranoid schizophrenia (SZ-N) as well as short-term antipsychotically treated schizophrenia (SZ-T), major depression (MDD), bipolar disorder (BD), dementia (D), and healthy controls (HC). Patients suffering from either IPS, SZ-N or a SZ-T showed significantly higher scores of BDII compared to HC, indicating that visual processing is already disturbed at an early state of the disease. For MDD, BD and D no statistically significant difference was found compared to HC. As the identification of individuals at high risk for developing schizophrenia relies on rating scales assessing subtle, pre-psychotic psychopathology, it would be of interest to have more diagnostic criteria available, testing, e.g. cognitive and perceptual impairment. We therefore analysed the receiver operating characteristic (ROC) curve, testing prodromal cases versus a clinically relevant sample of non-psychotic patients and controls, which included HC as well as the groups of patients suffering from MDD, BD or D revealing a AUC of 0.70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia. SN - 1433-8491 UR - https://www.unboundmedicine.com/medline/citation/19165523/Binocular_depth_inversion_as_a_paradigm_of_reduced_visual_information_processing_in_prodromal_state_antipsychotic_naïve_and_treated_schizophrenia_ L2 - https://dx.doi.org/10.1007/s00406-008-0851-6 DB - PRIME DP - Unbound Medicine ER -