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Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia.
Eur Arch Psychiatry Clin Neurosci 2009; 259(4):195-202EA

Abstract

The binocular depth inversion illusion test (BDII) represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. This study explores impairment of visual processing in different major psychiatric diseases investigating 313 subjects, suffering of either an initial prodromal state of psychosis (IPS) or a first-episode, antipsychotic-naïve paranoid schizophrenia (SZ-N) as well as short-term antipsychotically treated schizophrenia (SZ-T), major depression (MDD), bipolar disorder (BD), dementia (D), and healthy controls (HC). Patients suffering from either IPS, SZ-N or a SZ-T showed significantly higher scores of BDII compared to HC, indicating that visual processing is already disturbed at an early state of the disease. For MDD, BD and D no statistically significant difference was found compared to HC. As the identification of individuals at high risk for developing schizophrenia relies on rating scales assessing subtle, pre-psychotic psychopathology, it would be of interest to have more diagnostic criteria available, testing, e.g. cognitive and perceptual impairment. We therefore analysed the receiver operating characteristic (ROC) curve, testing prodromal cases versus a clinically relevant sample of non-psychotic patients and controls, which included HC as well as the groups of patients suffering from MDD, BD or D revealing a AUC of 0.70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia.

Authors+Show Affiliations

Dept. of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str. 62, 50924, Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19165523

Citation

Koethe, Dagmar, et al. "Binocular Depth Inversion as a Paradigm of Reduced Visual Information Processing in Prodromal State, Antipsychotic-naïve and Treated Schizophrenia." European Archives of Psychiatry and Clinical Neuroscience, vol. 259, no. 4, 2009, pp. 195-202.
Koethe D, Kranaster L, Hoyer C, et al. Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2009;259(4):195-202.
Koethe, D., Kranaster, L., Hoyer, C., Gross, S., Neatby, M. A., Schultze-Lutter, F., ... Leweke, F. M. (2009). Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 259(4), pp. 195-202. doi:10.1007/s00406-008-0851-6.
Koethe D, et al. Binocular Depth Inversion as a Paradigm of Reduced Visual Information Processing in Prodromal State, Antipsychotic-naïve and Treated Schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2009;259(4):195-202. PubMed PMID: 19165523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. AU - Koethe,Dagmar, AU - Kranaster,Laura, AU - Hoyer,Carolin, AU - Gross,Sonja, AU - Neatby,Miriam A, AU - Schultze-Lutter,Frauke, AU - Ruhrmann,Stephan, AU - Klosterkötter,Joachim, AU - Hellmich,Martin, AU - Leweke,F Markus, Y1 - 2009/01/22/ PY - 2007/09/05/received PY - 2008/08/29/accepted PY - 2009/1/24/entrez PY - 2009/1/24/pubmed PY - 2009/7/16/medline SP - 195 EP - 202 JF - European archives of psychiatry and clinical neuroscience JO - Eur Arch Psychiatry Clin Neurosci VL - 259 IS - 4 N2 - The binocular depth inversion illusion test (BDII) represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. This study explores impairment of visual processing in different major psychiatric diseases investigating 313 subjects, suffering of either an initial prodromal state of psychosis (IPS) or a first-episode, antipsychotic-naïve paranoid schizophrenia (SZ-N) as well as short-term antipsychotically treated schizophrenia (SZ-T), major depression (MDD), bipolar disorder (BD), dementia (D), and healthy controls (HC). Patients suffering from either IPS, SZ-N or a SZ-T showed significantly higher scores of BDII compared to HC, indicating that visual processing is already disturbed at an early state of the disease. For MDD, BD and D no statistically significant difference was found compared to HC. As the identification of individuals at high risk for developing schizophrenia relies on rating scales assessing subtle, pre-psychotic psychopathology, it would be of interest to have more diagnostic criteria available, testing, e.g. cognitive and perceptual impairment. We therefore analysed the receiver operating characteristic (ROC) curve, testing prodromal cases versus a clinically relevant sample of non-psychotic patients and controls, which included HC as well as the groups of patients suffering from MDD, BD or D revealing a AUC of 0.70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia. SN - 1433-8491 UR - https://www.unboundmedicine.com/medline/citation/19165523/Binocular_depth_inversion_as_a_paradigm_of_reduced_visual_information_processing_in_prodromal_state_antipsychotic_naïve_and_treated_schizophrenia_ L2 - https://dx.doi.org/10.1007/s00406-008-0851-6 DB - PRIME DP - Unbound Medicine ER -