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Relation of high-density lipoprotein cholesterol to mortality after percutaneous coronary interventions in patients with low-density lipoprotein <70 mg/dl.
Am J Cardiol. 2009 Feb 01; 103(3):350-4.AJ

Abstract

High-density lipoprotein (HDL) cholesterol level is a strong predictor of morbidity and mortality in the general population. Conflicting data exist on the protective effects of high HDL cholesterol in patients with optimal low-density lipoprotein (LDL) cholesterol levels. To determine the association of high HDL cholesterol with mortality in patients with LDL cholesterol levels <70 mg/dl who undergo percutaneous coronary intervention, 3,616 consecutive patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention from July 1, 1999, to June 1, 2007, were retrospectively analyzed and followed through July 1, 2007. All-cause mortality was identified using the National Death Index. The mortality rates was 34.7, 25.2, 23.7, and 18.8 per 1,000 person-years in patients with HDL cholesterol levels of <40, 40 to 49, 50 to 59, and > or =60 mg/dl, respectively (p for trend <0.001). After multivariate adjustment for demographic characteristics, cigarette smoking, biochemical variables, and co-morbid conditions, the hazard ratios for mortality in patients with HDL cholesterol levels of 40 to 49, 50 to 59, and > or =60 mg/dl, compared with their counterparts with HDL cholesterol levels <40 mg/dl, were 0.68 (95% confidence interval [CI] 0.50 to 0.93), 0.55 (95% CI 0.35 to 0.85), and 0.45 (95% CI 0.27 to 0.74), respectively. For each 1-SD increase in HDL cholesterol level (14 mg/dl), the multivariate-adjusted hazard ratio for all-cause mortality was 0.68 (95% CI 0.58 to 0.79). In conclusion, in patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention, a strong inverse association was present between HDL cholesterol level and all-cause mortality.

Authors+Show Affiliations

Cardiac Catheterization Laboratory of the Cardiovascular Institute, Mount Sinai Hospital, New York, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19166688

Citation

Kini, Annapoorna S., et al. "Relation of High-density Lipoprotein Cholesterol to Mortality After Percutaneous Coronary Interventions in Patients With Low-density Lipoprotein <70 Mg/dl." The American Journal of Cardiology, vol. 103, no. 3, 2009, pp. 350-4.
Kini AS, Muntner P, Moreno PR, et al. Relation of high-density lipoprotein cholesterol to mortality after percutaneous coronary interventions in patients with low-density lipoprotein <70 mg/dl. Am J Cardiol. 2009;103(3):350-4.
Kini, A. S., Muntner, P., Moreno, P. R., Mann, D., Krishnan, P., Kim, M. C., Rafael, O. C., Farkouh, M. E., & Sharma, S. K. (2009). Relation of high-density lipoprotein cholesterol to mortality after percutaneous coronary interventions in patients with low-density lipoprotein <70 mg/dl. The American Journal of Cardiology, 103(3), 350-4. https://doi.org/10.1016/j.amjcard.2008.09.087
Kini AS, et al. Relation of High-density Lipoprotein Cholesterol to Mortality After Percutaneous Coronary Interventions in Patients With Low-density Lipoprotein <70 Mg/dl. Am J Cardiol. 2009 Feb 1;103(3):350-4. PubMed PMID: 19166688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of high-density lipoprotein cholesterol to mortality after percutaneous coronary interventions in patients with low-density lipoprotein <70 mg/dl. AU - Kini,Annapoorna S, AU - Muntner,Paul, AU - Moreno,Pedro R, AU - Mann,Devin, AU - Krishnan,Prakash, AU - Kim,Michael C, AU - Rafael,Oana C, AU - Farkouh,Michael E, AU - Sharma,Samin K, Y1 - 2008/11/19/ PY - 2008/07/24/received PY - 2008/09/23/revised PY - 2008/09/23/accepted PY - 2009/1/27/entrez PY - 2009/1/27/pubmed PY - 2009/2/12/medline SP - 350 EP - 4 JF - The American journal of cardiology JO - Am J Cardiol VL - 103 IS - 3 N2 - High-density lipoprotein (HDL) cholesterol level is a strong predictor of morbidity and mortality in the general population. Conflicting data exist on the protective effects of high HDL cholesterol in patients with optimal low-density lipoprotein (LDL) cholesterol levels. To determine the association of high HDL cholesterol with mortality in patients with LDL cholesterol levels <70 mg/dl who undergo percutaneous coronary intervention, 3,616 consecutive patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention from July 1, 1999, to June 1, 2007, were retrospectively analyzed and followed through July 1, 2007. All-cause mortality was identified using the National Death Index. The mortality rates was 34.7, 25.2, 23.7, and 18.8 per 1,000 person-years in patients with HDL cholesterol levels of <40, 40 to 49, 50 to 59, and > or =60 mg/dl, respectively (p for trend <0.001). After multivariate adjustment for demographic characteristics, cigarette smoking, biochemical variables, and co-morbid conditions, the hazard ratios for mortality in patients with HDL cholesterol levels of 40 to 49, 50 to 59, and > or =60 mg/dl, compared with their counterparts with HDL cholesterol levels <40 mg/dl, were 0.68 (95% confidence interval [CI] 0.50 to 0.93), 0.55 (95% CI 0.35 to 0.85), and 0.45 (95% CI 0.27 to 0.74), respectively. For each 1-SD increase in HDL cholesterol level (14 mg/dl), the multivariate-adjusted hazard ratio for all-cause mortality was 0.68 (95% CI 0.58 to 0.79). In conclusion, in patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention, a strong inverse association was present between HDL cholesterol level and all-cause mortality. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/19166688/Relation_of_high_density_lipoprotein_cholesterol_to_mortality_after_percutaneous_coronary_interventions_in_patients_with_low_density_lipoprotein_<70_mg/dl_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(08)01703-7 DB - PRIME DP - Unbound Medicine ER -