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The importance of nitric oxide in social dysfunction.
Behav Brain Res. 2009 Jun 08; 200(1):113-6.BB

Abstract

Schizophrenia is a chronic disorder generally considered to encompass positive symptoms, negative symptoms and cognitive deficits. Increasing attention has been paid to the social cognitive deficits of the disorder as these dysfunctions are particularly handicapping, predictive of functional outcome and show poor treatment response. Phencyclidine (PCP) is a psychotomimetic drug used to model the different aspects of schizophrenia in experimental animal models. PCP-induced cognitive deficits and hyperlocomotion may be blocked by pretreatment with nitric oxide (NO) synthase inhibitors in rodents. The present study was carried out to evaluate the acute effects of PCP and NO synthase inhibition on social interaction in male Sprague-Dawley rats. The NO synthase inhibitor, L-NAME (10mg/kg) and PCP (2mg/kg) was injected subcutaneously to rats, which were then tested in pairs for social interactive behaviour. Twenty-four hours after the initial test a drug-free social interaction test was carried out to assess the rats' memory of the previous social interaction. The results showed that PCP reduced the time of social interaction on Day 1 compared to controls, and that pretreatment with the NO synthase inhibitor, L-NAME, attenuated this reduction towards control levels. Neither locomotor activity, nor frequency of social interactions were affected by the PCP treatment, suggesting that the PCP-induced effects observed were not due to drug-induced stereotypies. In combination with increasing clinical evidence for the involvement of NO in the pathophysiology of schizophrenia, the present results indicate that NO synthase inhibition may be a potentially new treatment strategy for alleviating social dysfunction in schizophrenia.

Authors+Show Affiliations

Department of Pharmacology, The Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19166879

Citation

Wass, Caroline, et al. "The Importance of Nitric Oxide in Social Dysfunction." Behavioural Brain Research, vol. 200, no. 1, 2009, pp. 113-6.
Wass C, Klamer D, Fejgin K, et al. The importance of nitric oxide in social dysfunction. Behav Brain Res. 2009;200(1):113-6.
Wass, C., Klamer, D., Fejgin, K., & Pålsson, E. (2009). The importance of nitric oxide in social dysfunction. Behavioural Brain Research, 200(1), 113-6. https://doi.org/10.1016/j.bbr.2009.01.002
Wass C, et al. The Importance of Nitric Oxide in Social Dysfunction. Behav Brain Res. 2009 Jun 8;200(1):113-6. PubMed PMID: 19166879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of nitric oxide in social dysfunction. AU - Wass,Caroline, AU - Klamer,Daniel, AU - Fejgin,Kim, AU - Pålsson,Erik, Y1 - 2009/01/08/ PY - 2008/10/03/received PY - 2008/12/28/revised PY - 2009/01/03/accepted PY - 2009/1/27/entrez PY - 2009/1/27/pubmed PY - 2009/6/19/medline SP - 113 EP - 6 JF - Behavioural brain research JO - Behav Brain Res VL - 200 IS - 1 N2 - Schizophrenia is a chronic disorder generally considered to encompass positive symptoms, negative symptoms and cognitive deficits. Increasing attention has been paid to the social cognitive deficits of the disorder as these dysfunctions are particularly handicapping, predictive of functional outcome and show poor treatment response. Phencyclidine (PCP) is a psychotomimetic drug used to model the different aspects of schizophrenia in experimental animal models. PCP-induced cognitive deficits and hyperlocomotion may be blocked by pretreatment with nitric oxide (NO) synthase inhibitors in rodents. The present study was carried out to evaluate the acute effects of PCP and NO synthase inhibition on social interaction in male Sprague-Dawley rats. The NO synthase inhibitor, L-NAME (10mg/kg) and PCP (2mg/kg) was injected subcutaneously to rats, which were then tested in pairs for social interactive behaviour. Twenty-four hours after the initial test a drug-free social interaction test was carried out to assess the rats' memory of the previous social interaction. The results showed that PCP reduced the time of social interaction on Day 1 compared to controls, and that pretreatment with the NO synthase inhibitor, L-NAME, attenuated this reduction towards control levels. Neither locomotor activity, nor frequency of social interactions were affected by the PCP treatment, suggesting that the PCP-induced effects observed were not due to drug-induced stereotypies. In combination with increasing clinical evidence for the involvement of NO in the pathophysiology of schizophrenia, the present results indicate that NO synthase inhibition may be a potentially new treatment strategy for alleviating social dysfunction in schizophrenia. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19166879/The_importance_of_nitric_oxide_in_social_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00008-4 DB - PRIME DP - Unbound Medicine ER -