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Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation.
Immunobiology. 2009; 214(2):129-34.I

Abstract

In most of the diseases which are considered to benefit from propolis, cellular immune reaction is activated, neopterin levels in body fluids are increased and enhanced tryptophan degradation is observed. In this study, the immunomodulatory effects of six Turkish propolis samples were evaluated by using the in vitro model of peripheral blood mononuclear cells (PBMC). Concentrations of neopterin, tryptophan, kynurenine and pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) were determined and also the viability of the cells was checked with trypan blue and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test. In PBMC treated with mitogen phytohaemagglutinin, neopterin production and tryptophan degradation by enzyme indoleamine 2,3-dioxygenase (IDO) as well as release of cytokines was significantly enhanced and upon treatment with propolis extracts all these effects were dose-dependently suppressed. Results show an immunomodulatory effect of propolis extracts which includes down-regulation of IDO activity. IDO enzyme is considered to play an important role in the development of immunodeficiency and neuropsychiatric symptoms in patient with chronic inflammation. The suppression of tryptophan degradation by propolis extracts may therefore be related with some of its beneficial health properties in humans.

Authors+Show Affiliations

Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19167991

Citation

Girgin, Gozde, et al. "Immunomodulatory Effects of Turkish Propolis: Changes in Neopterin Release and Tryptophan Degradation." Immunobiology, vol. 214, no. 2, 2009, pp. 129-34.
Girgin G, Baydar T, Ledochowski M, et al. Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation. Immunobiology. 2009;214(2):129-34.
Girgin, G., Baydar, T., Ledochowski, M., Schennach, H., Bolukbasi, D. N., Sorkun, K., Salih, B., Sahin, G., & Fuchs, D. (2009). Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation. Immunobiology, 214(2), 129-34. https://doi.org/10.1016/j.imbio.2008.07.002
Girgin G, et al. Immunomodulatory Effects of Turkish Propolis: Changes in Neopterin Release and Tryptophan Degradation. Immunobiology. 2009;214(2):129-34. PubMed PMID: 19167991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation. AU - Girgin,Gozde, AU - Baydar,Terken, AU - Ledochowski,Maximilian, AU - Schennach,Harald, AU - Bolukbasi,Duygu Nur, AU - Sorkun,Kadriye, AU - Salih,Bekir, AU - Sahin,Gonul, AU - Fuchs,Dietmar, Y1 - 2008/08/26/ PY - 2008/05/29/received PY - 2008/06/26/revised PY - 2008/07/08/accepted PY - 2009/1/27/entrez PY - 2009/1/27/pubmed PY - 2009/4/11/medline SP - 129 EP - 34 JF - Immunobiology JO - Immunobiology VL - 214 IS - 2 N2 - In most of the diseases which are considered to benefit from propolis, cellular immune reaction is activated, neopterin levels in body fluids are increased and enhanced tryptophan degradation is observed. In this study, the immunomodulatory effects of six Turkish propolis samples were evaluated by using the in vitro model of peripheral blood mononuclear cells (PBMC). Concentrations of neopterin, tryptophan, kynurenine and pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) were determined and also the viability of the cells was checked with trypan blue and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test. In PBMC treated with mitogen phytohaemagglutinin, neopterin production and tryptophan degradation by enzyme indoleamine 2,3-dioxygenase (IDO) as well as release of cytokines was significantly enhanced and upon treatment with propolis extracts all these effects were dose-dependently suppressed. Results show an immunomodulatory effect of propolis extracts which includes down-regulation of IDO activity. IDO enzyme is considered to play an important role in the development of immunodeficiency and neuropsychiatric symptoms in patient with chronic inflammation. The suppression of tryptophan degradation by propolis extracts may therefore be related with some of its beneficial health properties in humans. SN - 1878-3279 UR - https://www.unboundmedicine.com/medline/citation/19167991/Immunomodulatory_effects_of_Turkish_propolis:_changes_in_neopterin_release_and_tryptophan_degradation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0171-2985(08)00067-3 DB - PRIME DP - Unbound Medicine ER -