Tags

Type your tag names separated by a space and hit enter

Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials.
Bone 2009; 44(5):948-53BONE

Abstract

INTRODUCTION

A number of RCTs have examined the role of soy isoflavones on bone mineral density (BMD) and yielded inconsistent results. This meta-analyses aims to assess the overall effect of soy isoflavones on BMD.

METHODS

We searched for all articles published in English from January 1990 to March, 2008. We included RCTs of soy isoflavone supplementation in women of at least one year duration. The main outcomes were BMD changes from baseline at the lumbar spine, total hip and femoral neck.

RESULTS

We identified 10 eligible RCTs containing 896 women. A mean dose of 87 mg soy isoflavones for at least one year did not significantly affect BMD changes. The mean (95%CI) differences in BMD changes (in mg/cm(2)/year) were 4.1 (-1.6, 9.8) (0.4%) at the lumbar spine, -1.5 (-7.2, 4.3) (-0.3%) at the femoral neck under random-effects model, and 2.5 (-0.5, 5.4) (0.2%) at the total hip by fix-effects model, respectively. Similar results were obtained in subgroup analyses by isoflavone sources (soy protein vs. isoflavone extract), ethnic differences (Asian vs. Western). Larger dose (>or=80 mg/d), but not lower dose (<80 mg/d), of isoflavone intervention tended to have a weak beneficial effect on spine BMD (p=0.08 vs. p=0.94).

CONCLUSIONS

Soy isoflavone supplementation is unlikely to have significant favorable on BMD at the lumbar spine and hip in women.

Authors+Show Affiliations

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19168161

Citation

Liu, Jing, et al. "Effect of Long-term Intervention of Soy Isoflavones On Bone Mineral Density in Women: a Meta-analysis of Randomized Controlled Trials." Bone, vol. 44, no. 5, 2009, pp. 948-53.
Liu J, Ho SC, Su YX, et al. Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. Bone. 2009;44(5):948-53.
Liu, J., Ho, S. C., Su, Y. X., Chen, W. Q., Zhang, C. X., & Chen, Y. M. (2009). Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. Bone, 44(5), pp. 948-53. doi:10.1016/j.bone.2008.12.020.
Liu J, et al. Effect of Long-term Intervention of Soy Isoflavones On Bone Mineral Density in Women: a Meta-analysis of Randomized Controlled Trials. Bone. 2009;44(5):948-53. PubMed PMID: 19168161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. AU - Liu,Jing, AU - Ho,Suzanne C, AU - Su,Yi-xiang, AU - Chen,Wei-qing, AU - Zhang,Cai-xia, AU - Chen,Yu-ming, Y1 - 2009/01/03/ PY - 2008/09/26/received PY - 2008/12/10/revised PY - 2008/12/23/accepted PY - 2009/1/27/entrez PY - 2009/1/27/pubmed PY - 2009/7/28/medline SP - 948 EP - 53 JF - Bone JO - Bone VL - 44 IS - 5 N2 - INTRODUCTION: A number of RCTs have examined the role of soy isoflavones on bone mineral density (BMD) and yielded inconsistent results. This meta-analyses aims to assess the overall effect of soy isoflavones on BMD. METHODS: We searched for all articles published in English from January 1990 to March, 2008. We included RCTs of soy isoflavone supplementation in women of at least one year duration. The main outcomes were BMD changes from baseline at the lumbar spine, total hip and femoral neck. RESULTS: We identified 10 eligible RCTs containing 896 women. A mean dose of 87 mg soy isoflavones for at least one year did not significantly affect BMD changes. The mean (95%CI) differences in BMD changes (in mg/cm(2)/year) were 4.1 (-1.6, 9.8) (0.4%) at the lumbar spine, -1.5 (-7.2, 4.3) (-0.3%) at the femoral neck under random-effects model, and 2.5 (-0.5, 5.4) (0.2%) at the total hip by fix-effects model, respectively. Similar results were obtained in subgroup analyses by isoflavone sources (soy protein vs. isoflavone extract), ethnic differences (Asian vs. Western). Larger dose (>or=80 mg/d), but not lower dose (<80 mg/d), of isoflavone intervention tended to have a weak beneficial effect on spine BMD (p=0.08 vs. p=0.94). CONCLUSIONS: Soy isoflavone supplementation is unlikely to have significant favorable on BMD at the lumbar spine and hip in women. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/19168161/Effect_of_long_term_intervention_of_soy_isoflavones_on_bone_mineral_density_in_women:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(08)00982-4 DB - PRIME DP - Unbound Medicine ER -