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Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity.
Eur J Med Chem. 2009 Jul; 44(7):2834-9.EJ

Abstract

Experimental and theoretical investigation of the antioxidant activity of melatonin is carried out. The theoretical approach comprises the evaluation of several appropriate descriptors of scavenging activity with the help of quantum-chemistry methods. The values obtained are compared with available data for substances with established antioxidant properties. One of the most widely used markers for in vivo free radical oxidation processes is malondialdehyde (MDA) as an end product of membrane lipid peroxidation. Experimental support of the computed scavenging parameters is provided by estimation of the effect of supplementary melatonin therapy on the plasma levels of MDA in CRF patients on maintenance HD therapy. Different reaction paths have been considered and related to the obtained data, allowing speculations about the reaction mechanism and the antioxidant potential of melatonin for practical purposes.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Velkov ZA
Department of Chemistry, South-West University Neofit Rilski, Blagoevgrad, Bulgaria. jivko_av@abv.bg
Velkov YZh
No affiliation info available
Galunska BT
No affiliation info available
Paskalev DN
No affiliation info available
Tadjer AV
No affiliation info available

MeSH

AdultAgedBiomarkersCase-Control StudiesCell MembraneFemaleFree Radical ScavengersFree RadicalsHumansKidney Failure, ChronicLipid PeroxidationMaleMalondialdehydeMelatoninMiddle AgedOxidation-ReductionQuantum TheoryRenal Dialysis

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19168264

Citation

Velkov, Zhivko A., et al. "Melatonin: Quantum-chemical and Biochemical Investigation of Antioxidant Activity." European Journal of Medicinal Chemistry, vol. 44, no. 7, 2009, pp. 2834-9.
Velkov ZA, Velkov YZh, Galunska BT, et al. Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity. Eur J Med Chem. 2009;44(7):2834-9.
Velkov, Z. A., Velkov, Y. Z. h., Galunska, B. T., Paskalev, D. N., & Tadjer, A. V. (2009). Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity. European Journal of Medicinal Chemistry, 44(7), 2834-9. https://doi.org/10.1016/j.ejmech.2008.12.017
Velkov ZA, et al. Melatonin: Quantum-chemical and Biochemical Investigation of Antioxidant Activity. Eur J Med Chem. 2009;44(7):2834-9. PubMed PMID: 19168264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity. AU - Velkov,Zhivko A, AU - Velkov,Yasen Zh, AU - Galunska,Bistra T, AU - Paskalev,Dobrin N, AU - Tadjer,Alia V, Y1 - 2008/12/25/ PY - 2008/06/16/received PY - 2008/11/12/revised PY - 2008/12/15/accepted PY - 2009/1/27/entrez PY - 2009/1/27/pubmed PY - 2009/7/25/medline SP - 2834 EP - 9 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 44 IS - 7 N2 - Experimental and theoretical investigation of the antioxidant activity of melatonin is carried out. The theoretical approach comprises the evaluation of several appropriate descriptors of scavenging activity with the help of quantum-chemistry methods. The values obtained are compared with available data for substances with established antioxidant properties. One of the most widely used markers for in vivo free radical oxidation processes is malondialdehyde (MDA) as an end product of membrane lipid peroxidation. Experimental support of the computed scavenging parameters is provided by estimation of the effect of supplementary melatonin therapy on the plasma levels of MDA in CRF patients on maintenance HD therapy. Different reaction paths have been considered and related to the obtained data, allowing speculations about the reaction mechanism and the antioxidant potential of melatonin for practical purposes. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/19168264/Melatonin:_Quantum_chemical_and_biochemical_investigation_of_antioxidant_activity_ DB - PRIME DP - Unbound Medicine ER -