Tags

Type your tag names separated by a space and hit enter

Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline.
Neurology 2009; 72(4):361-7Neur

Abstract

BACKGROUND

In some prospective studies, associations of serum vitamin B(12) and homocysteine concentrations with cognitive decline have been reported but few have examined the role of methylmalonic acid, a more specific marker of vitamin B(12) deficiency than homocysteine.

OBJECTIVE

The aim of the study was to determine whether serum concentrations of vitamin B(12) or selected metabolites are related to cognitive decline.

METHODS

A total of 516 subjects were selected in a stratified random sampling design from among Chicago Health and Aging Project participants for clinical evaluation. We used linear mixed models to examine the association of blood markers of vitamin B(12) status to change in cognitive scores over 6 years. Cognitive function was assessed every 3 years and measured as the sum of standardized scores on four tests.

RESULTS

Probable vitamin B(12) deficiency was observed in 14.2% of the sample. Elevated serum concentrations of homocysteine were present in 19.2% of subjects, and of methylmalonic acid, in 36.4%. Higher serum methylmalonic acid concentrations were predictive of faster rates of cognitive decline (beta = -0.00016, SE = 0.0001, p = 0.004) and higher serum vitamin B(12) concentrations were associated with slower rates of cognitive decline (beta = +0.00013, SE < 0.0001, p = 0.005) in multivariable adjusted mixed models. Serum concentrations of homocysteine had no relationship to cognitive decline.

CONCLUSIONS

Serum methylmalonic acid and vitamin B(12) concentrations may be the more important risk factors for cognitive decline when compared to serum homocysteine concentrations, particularly in older populations exposed to food fortification and possible supplements containing folic acid.

Authors+Show Affiliations

Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL 60612, USA. ctangney@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19171834

Citation

Tangney, Christine C., et al. "Biochemical Indicators of Vitamin B12 and Folate Insufficiency and Cognitive Decline." Neurology, vol. 72, no. 4, 2009, pp. 361-7.
Tangney CC, Tang Y, Evans DA, et al. Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology. 2009;72(4):361-7.
Tangney, C. C., Tang, Y., Evans, D. A., & Morris, M. C. (2009). Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology, 72(4), pp. 361-7. doi:10.1212/01.wnl.0000341272.48617.b0.
Tangney CC, et al. Biochemical Indicators of Vitamin B12 and Folate Insufficiency and Cognitive Decline. Neurology. 2009 Jan 27;72(4):361-7. PubMed PMID: 19171834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. AU - Tangney,Christine C, AU - Tang,Yuxiao, AU - Evans,Denis A, AU - Morris,Martha Clare, PY - 2009/1/28/entrez PY - 2009/1/28/pubmed PY - 2009/2/21/medline SP - 361 EP - 7 JF - Neurology JO - Neurology VL - 72 IS - 4 N2 - BACKGROUND: In some prospective studies, associations of serum vitamin B(12) and homocysteine concentrations with cognitive decline have been reported but few have examined the role of methylmalonic acid, a more specific marker of vitamin B(12) deficiency than homocysteine. OBJECTIVE: The aim of the study was to determine whether serum concentrations of vitamin B(12) or selected metabolites are related to cognitive decline. METHODS: A total of 516 subjects were selected in a stratified random sampling design from among Chicago Health and Aging Project participants for clinical evaluation. We used linear mixed models to examine the association of blood markers of vitamin B(12) status to change in cognitive scores over 6 years. Cognitive function was assessed every 3 years and measured as the sum of standardized scores on four tests. RESULTS: Probable vitamin B(12) deficiency was observed in 14.2% of the sample. Elevated serum concentrations of homocysteine were present in 19.2% of subjects, and of methylmalonic acid, in 36.4%. Higher serum methylmalonic acid concentrations were predictive of faster rates of cognitive decline (beta = -0.00016, SE = 0.0001, p = 0.004) and higher serum vitamin B(12) concentrations were associated with slower rates of cognitive decline (beta = +0.00013, SE < 0.0001, p = 0.005) in multivariable adjusted mixed models. Serum concentrations of homocysteine had no relationship to cognitive decline. CONCLUSIONS: Serum methylmalonic acid and vitamin B(12) concentrations may be the more important risk factors for cognitive decline when compared to serum homocysteine concentrations, particularly in older populations exposed to food fortification and possible supplements containing folic acid. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/19171834/Biochemical_indicators_of_vitamin_B12_and_folate_insufficiency_and_cognitive_decline_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=19171834 DB - PRIME DP - Unbound Medicine ER -