Tags

Type your tag names separated by a space and hit enter

Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women.
Osteoporos Int. 2009 Sep; 20(9):1603-11.OI

Abstract

Current treatments for postmenopausal osteoporosis suffer from side effects. Safe and natural milk proteins, ribonuclease, and lactoferrin promote formation of new capillaries and bone formation. A ribonuclease-enriched lactoferrin supplement studied here, demonstrates significant reduction in resorption and increase in formation, towards restoring the balance of bone turnover within 6 months.

INTRODUCTION

Osteoporosis, a major health issue among postmenopausal women, causes increased bone resorption and reduced bone formation. A reduction in angiogenesis could also contribute to this imbalance. Current treatments such as hormone replacement therapy and bisphosphonates have drawbacks of severe side effects. Milk ribonuclease (RNase) is known to promote angiogenesis and lactoferrin (LF) to stimulate bone formation by osteoblasts. We examine the effect of ribonuclease-enriched lactoferrin supplement on the bone health of postmenopausal women.

METHODS

A total of 38 healthy, postmenopausal women, aged 45 to 60 years were randomized into placebo or RNAse-enriched-LF (R-ELF) supplement groups. The bone health status was monitored by assessing bone resorption markers, serum N-telopeptides (NTx), and urine deoxypyridinoline (Dpd) crosslinks and serum bone formation markers, bone-specific alkaline phosphatase (BAP), and osteocalcin (OC).

RESULTS

R-ELF supplementation demonstrated a decrease in urine Dpd levels by 14% (19% increase for placebo) and serum NTx maintained at 24% of the baseline (41% for placebo), while serum BAP and OC levels showed a 45% and 16% elevation (25% and 5% for placebo).

CONCLUSIONS

R-ELF supplementation demonstrated a statistically significant reduction in bone resorption and increase in osteoblastic bone formation, to restore the balance of bone turnover within a short period.

Authors+Show Affiliations

N-terminus Research Laboratory, 981 Corporate Center Dr., # 110, Pomona, CA 91768, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19172341

Citation

Bharadwaj, S, et al. "Milk Ribonuclease-enriched Lactoferrin Induces Positive Effects On Bone Turnover Markers in Postmenopausal Women." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 20, no. 9, 2009, pp. 1603-11.
Bharadwaj S, Naidu AG, Betageri GV, et al. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women. Osteoporos Int. 2009;20(9):1603-11.
Bharadwaj, S., Naidu, A. G., Betageri, G. V., Prasadarao, N. V., & Naidu, A. S. (2009). Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 20(9), 1603-11. https://doi.org/10.1007/s00198-009-0839-8
Bharadwaj S, et al. Milk Ribonuclease-enriched Lactoferrin Induces Positive Effects On Bone Turnover Markers in Postmenopausal Women. Osteoporos Int. 2009;20(9):1603-11. PubMed PMID: 19172341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women. AU - Bharadwaj,S, AU - Naidu,A G T, AU - Betageri,G V, AU - Prasadarao,N V, AU - Naidu,A S, Y1 - 2009/01/27/ PY - 2008/10/17/received PY - 2008/12/12/accepted PY - 2009/1/28/entrez PY - 2009/1/28/pubmed PY - 2010/8/31/medline SP - 1603 EP - 11 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 20 IS - 9 N2 - UNLABELLED: Current treatments for postmenopausal osteoporosis suffer from side effects. Safe and natural milk proteins, ribonuclease, and lactoferrin promote formation of new capillaries and bone formation. A ribonuclease-enriched lactoferrin supplement studied here, demonstrates significant reduction in resorption and increase in formation, towards restoring the balance of bone turnover within 6 months. INTRODUCTION: Osteoporosis, a major health issue among postmenopausal women, causes increased bone resorption and reduced bone formation. A reduction in angiogenesis could also contribute to this imbalance. Current treatments such as hormone replacement therapy and bisphosphonates have drawbacks of severe side effects. Milk ribonuclease (RNase) is known to promote angiogenesis and lactoferrin (LF) to stimulate bone formation by osteoblasts. We examine the effect of ribonuclease-enriched lactoferrin supplement on the bone health of postmenopausal women. METHODS: A total of 38 healthy, postmenopausal women, aged 45 to 60 years were randomized into placebo or RNAse-enriched-LF (R-ELF) supplement groups. The bone health status was monitored by assessing bone resorption markers, serum N-telopeptides (NTx), and urine deoxypyridinoline (Dpd) crosslinks and serum bone formation markers, bone-specific alkaline phosphatase (BAP), and osteocalcin (OC). RESULTS: R-ELF supplementation demonstrated a decrease in urine Dpd levels by 14% (19% increase for placebo) and serum NTx maintained at 24% of the baseline (41% for placebo), while serum BAP and OC levels showed a 45% and 16% elevation (25% and 5% for placebo). CONCLUSIONS: R-ELF supplementation demonstrated a statistically significant reduction in bone resorption and increase in osteoblastic bone formation, to restore the balance of bone turnover within a short period. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/19172341/full_citation/Milk_ribonuclease_enriched_lactoferrin_induces_positive_effects_on_bone_turnover_markers_in_postmenopausal_women_ L2 - https://doi.org/10.1007/s00198-009-0839-8 DB - PRIME DP - Unbound Medicine ER -