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Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women.

Abstract

Current treatments for postmenopausal osteoporosis suffer from side effects. Safe and natural milk proteins, ribonuclease, and lactoferrin promote formation of new capillaries and bone formation. A ribonuclease-enriched lactoferrin supplement studied here, demonstrates significant reduction in resorption and increase in formation, towards restoring the balance of bone turnover within 6 months.

INTRODUCTION

Osteoporosis, a major health issue among postmenopausal women, causes increased bone resorption and reduced bone formation. A reduction in angiogenesis could also contribute to this imbalance. Current treatments such as hormone replacement therapy and bisphosphonates have drawbacks of severe side effects. Milk ribonuclease (RNase) is known to promote angiogenesis and lactoferrin (LF) to stimulate bone formation by osteoblasts. We examine the effect of ribonuclease-enriched lactoferrin supplement on the bone health of postmenopausal women.

METHODS

A total of 38 healthy, postmenopausal women, aged 45 to 60 years were randomized into placebo or RNAse-enriched-LF (R-ELF) supplement groups. The bone health status was monitored by assessing bone resorption markers, serum N-telopeptides (NTx), and urine deoxypyridinoline (Dpd) crosslinks and serum bone formation markers, bone-specific alkaline phosphatase (BAP), and osteocalcin (OC).

RESULTS

R-ELF supplementation demonstrated a decrease in urine Dpd levels by 14% (19% increase for placebo) and serum NTx maintained at 24% of the baseline (41% for placebo), while serum BAP and OC levels showed a 45% and 16% elevation (25% and 5% for placebo).

CONCLUSIONS

R-ELF supplementation demonstrated a statistically significant reduction in bone resorption and increase in osteoblastic bone formation, to restore the balance of bone turnover within a short period.

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  • Authors+Show Affiliations

    ,

    N-terminus Research Laboratory, 981 Corporate Center Dr., # 110, Pomona, CA 91768, USA.

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    MeSH

    Alkaline Phosphatase
    Amino Acids
    Animals
    Biological Markers
    Bone Remodeling
    Bone Resorption
    Calcium, Dietary
    Collagen Type I
    Dietary Supplements
    Female
    Humans
    Lactoferrin
    Middle Aged
    Milk
    Osteocalcin
    Osteoporosis, Postmenopausal
    Peptides
    Postmenopause
    Ribonucleases

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19172341