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Glycemic risk factors of diabetic vascular complications: the role of glycemic variability.
Diabetes Metab Res Rev. 2009 Mar; 25(3):199-207.DM

Abstract

Achieving adequate targets relatively to all risk factors is considered a standard of care for patients with diabetes mellitus. To date, current guidelines underline the importance of the 'glucose triad' (post-prandial glucose, fasting plasma glucose and glycated haemoglobin) as the three glycemic factors that should be controlled in diabetes care; however, several literature data show that optimizing glycemic control needs achieving a control of glycemic variations. The objective of the present work is reviewing biological and clinical data supporting the role of glycemic variability, its measurement and relationship with the three other well-known glycemic risk factors and evidencing the areas that need further investigation. At last, we propose a simple model that summarizes the 'glucose triad' plus the 'new' risk factor glycemic variability (the 'Pyramid of the Risk').

Authors+Show Affiliations

Diabetologia, Catholic University, Rome, Italy. frazac@fastwebnet.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19172575

Citation

Zaccardi, Francesco, et al. "Glycemic Risk Factors of Diabetic Vascular Complications: the Role of Glycemic Variability." Diabetes/metabolism Research and Reviews, vol. 25, no. 3, 2009, pp. 199-207.
Zaccardi F, Pitocco D, Ghirlanda G. Glycemic risk factors of diabetic vascular complications: the role of glycemic variability. Diabetes Metab Res Rev. 2009;25(3):199-207.
Zaccardi, F., Pitocco, D., & Ghirlanda, G. (2009). Glycemic risk factors of diabetic vascular complications: the role of glycemic variability. Diabetes/metabolism Research and Reviews, 25(3), 199-207. https://doi.org/10.1002/dmrr.938
Zaccardi F, Pitocco D, Ghirlanda G. Glycemic Risk Factors of Diabetic Vascular Complications: the Role of Glycemic Variability. Diabetes Metab Res Rev. 2009;25(3):199-207. PubMed PMID: 19172575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic risk factors of diabetic vascular complications: the role of glycemic variability. AU - Zaccardi,Francesco, AU - Pitocco,Dario, AU - Ghirlanda,Giovanni, PY - 2009/1/28/entrez PY - 2009/1/28/pubmed PY - 2009/5/22/medline SP - 199 EP - 207 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab Res Rev VL - 25 IS - 3 N2 - Achieving adequate targets relatively to all risk factors is considered a standard of care for patients with diabetes mellitus. To date, current guidelines underline the importance of the 'glucose triad' (post-prandial glucose, fasting plasma glucose and glycated haemoglobin) as the three glycemic factors that should be controlled in diabetes care; however, several literature data show that optimizing glycemic control needs achieving a control of glycemic variations. The objective of the present work is reviewing biological and clinical data supporting the role of glycemic variability, its measurement and relationship with the three other well-known glycemic risk factors and evidencing the areas that need further investigation. At last, we propose a simple model that summarizes the 'glucose triad' plus the 'new' risk factor glycemic variability (the 'Pyramid of the Risk'). SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/19172575/Glycemic_risk_factors_of_diabetic_vascular_complications:_the_role_of_glycemic_variability_ L2 - https://doi.org/10.1002/dmrr.938 DB - PRIME DP - Unbound Medicine ER -