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Mesenchymal stem cells in health and disease.
Nat Rev Immunol 2008; 8(9):726-36NR

Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches.

Authors+Show Affiliations

Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy. auccelli@neurologia.unige.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19172693

Citation

Uccelli, Antonio, et al. "Mesenchymal Stem Cells in Health and Disease." Nature Reviews. Immunology, vol. 8, no. 9, 2008, pp. 726-36.
Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8(9):726-36.
Uccelli, A., Moretta, L., & Pistoia, V. (2008). Mesenchymal stem cells in health and disease. Nature Reviews. Immunology, 8(9), pp. 726-36. doi:10.1038/nri2395.
Uccelli A, Moretta L, Pistoia V. Mesenchymal Stem Cells in Health and Disease. Nat Rev Immunol. 2008;8(9):726-36. PubMed PMID: 19172693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stem cells in health and disease. AU - Uccelli,Antonio, AU - Moretta,Lorenzo, AU - Pistoia,Vito, PY - 2009/1/28/entrez PY - 2009/1/28/pubmed PY - 2009/2/7/medline SP - 726 EP - 36 JF - Nature reviews. Immunology JO - Nat. Rev. Immunol. VL - 8 IS - 9 N2 - Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches. SN - 1474-1733 UR - https://www.unboundmedicine.com/medline/citation/19172693/Mesenchymal_stem_cells_in_health_and_disease_ L2 - http://dx.doi.org/10.1038/nri2395 DB - PRIME DP - Unbound Medicine ER -