Tags

Type your tag names separated by a space and hit enter

Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil.
Acta Anaesthesiol Scand. 2009 Mar; 53(3):369-75.AA

Abstract

BACKGROUND

In obese patients, depth of anaesthesia monitoring could be useful in titrating intravenous anaesthetics. We hypothesized that depth of anaesthesia monitoring would reduce recovery time and use of anaesthetics in obese patients receiving propofol and remifentanil.

METHODS

We investigated 38 patients with a body mass index >or=30 kg/m(2) scheduled for an abdominal hysterectomy. Patients were randomized to either titration of propofol and remifentanil according to a cerebral state monitor (CSM group) or according to usual clinical criteria (control group). The primary end point was time to eye opening and this was assessed by a blinded observer.

RESULTS

Time to eye opening was 11.8 min in the CSM group vs. 13.4 min in the control group (P=0.58). The average infusion rate for propofol was a median of 516 vs. 617 mg/h (P=0.24) and for remifentanil 2393 vs. 2708 microg/h (P=0.04). During surgery, when the cerebral state index was continuously between 40 and 60, the corresponding optimal propofol infusion rate was 10 mg/kg/h based on ideal body weight.

CONCLUSION

No significant reduction in time to eye opening could be demonstrated when a CSM was used to titrate propofol and remifentanil in obese patients undergoing a hysterectomy. A significant reduction in remifentanil consumption was found.

Authors+Show Affiliations

Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. meyhoff@rh.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19173688

Citation

Meyhoff, C S., et al. "Depth of Anaesthesia Monitoring in Obese Patients: a Randomized Study of Propofol-remifentanil." Acta Anaesthesiologica Scandinavica, vol. 53, no. 3, 2009, pp. 369-75.
Meyhoff CS, Henneberg SW, Jørgensen BG, et al. Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil. Acta Anaesthesiol Scand. 2009;53(3):369-75.
Meyhoff, C. S., Henneberg, S. W., Jørgensen, B. G., Gätke, M. R., & Rasmussen, L. S. (2009). Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil. Acta Anaesthesiologica Scandinavica, 53(3), 369-75. https://doi.org/10.1111/j.1399-6576.2008.01872.x
Meyhoff CS, et al. Depth of Anaesthesia Monitoring in Obese Patients: a Randomized Study of Propofol-remifentanil. Acta Anaesthesiol Scand. 2009;53(3):369-75. PubMed PMID: 19173688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil. AU - Meyhoff,C S, AU - Henneberg,S W, AU - Jørgensen,B G, AU - Gätke,M R, AU - Rasmussen,L S, Y1 - 2009/01/23/ PY - 2009/1/29/entrez PY - 2009/1/29/pubmed PY - 2009/4/8/medline SP - 369 EP - 75 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 53 IS - 3 N2 - BACKGROUND: In obese patients, depth of anaesthesia monitoring could be useful in titrating intravenous anaesthetics. We hypothesized that depth of anaesthesia monitoring would reduce recovery time and use of anaesthetics in obese patients receiving propofol and remifentanil. METHODS: We investigated 38 patients with a body mass index >or=30 kg/m(2) scheduled for an abdominal hysterectomy. Patients were randomized to either titration of propofol and remifentanil according to a cerebral state monitor (CSM group) or according to usual clinical criteria (control group). The primary end point was time to eye opening and this was assessed by a blinded observer. RESULTS: Time to eye opening was 11.8 min in the CSM group vs. 13.4 min in the control group (P=0.58). The average infusion rate for propofol was a median of 516 vs. 617 mg/h (P=0.24) and for remifentanil 2393 vs. 2708 microg/h (P=0.04). During surgery, when the cerebral state index was continuously between 40 and 60, the corresponding optimal propofol infusion rate was 10 mg/kg/h based on ideal body weight. CONCLUSION: No significant reduction in time to eye opening could be demonstrated when a CSM was used to titrate propofol and remifentanil in obese patients undergoing a hysterectomy. A significant reduction in remifentanil consumption was found. SN - 1399-6576 UR - https://www.unboundmedicine.com/medline/citation/19173688/Depth_of_anaesthesia_monitoring_in_obese_patients:_a_randomized_study_of_propofol_remifentanil_ L2 - https://doi.org/10.1111/j.1399-6576.2008.01872.x DB - PRIME DP - Unbound Medicine ER -