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Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients.
Med Clin (Barc). 2009 Jan 17; 132(1):1-6.MC

Abstract

BACKGROUND AND OBJECTIVE

The aim of the study was to assess the association of serum uric acid levels with microalbuminuria -urinary albumin excretion (UAE)> or = 30mg/24h-.

PATIENTS AND METHOD

Cross-sectional study in 429 (220 women) hypertensive, non diabetic, never treated patients (mean age: 47 years) with glomerular filtration rate > or =60ml/min/1.73m(2).

RESULTS

The prevalence of microalbuminuria was 20.5%; 18% had hyperuricemia and 47% fulfilled the criteria for metabolic syndrome (MS). Baseline UAE correlated in the unvaried analysis to diastolic blood pressure, waist circumference, high-density lipoprotein cholesterol and uric acid. In multiple linear regression models, only MS (beta=0.113; p=0.03), and serum uric acid values (beta=0.04; p=0.05) were independently associated with logUAE, after adjustment for age and sex. Hyperuricemia (serum uric acid level > or =7.0mg/dl for men and > or =6.5mg/dl for women; odds ratio=2.18; 95% confidence interval, 1.21-3.92; p=0.010), and MS (odds ratio=2.16; 95% confidence interval, 1.32-3.53; p=0.002) were independently associated with a higher risk of microalbuminuria in multiple logistic regression analyses. The prevalence of microalbuminuria was 45.8% in patients with coexistent MS and hyperuricemia, as compared to 13.6% in hypertensive patients without it (p<0.001). In patients with concomitant MS and hyperuricemia the probability of being microalbuminuric was 3.7 times higher than in patients without those factors.

CONCLUSION

Serum uric acid level is associated with microalbuminuria. Coexistence of MS and hyperuricemia in hypertensive patients increases almost 4 times the odds of being microalbuminuric.

Authors+Show Affiliations

Unidad de Hipertensión, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, España.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19174057

Citation

Rodilla, Enrique, et al. "Association Between Serum Uric Acid, Metabolic Syndrome and Microalbuminuria in Previously Untreated Essential Hypertensive Patients." Medicina Clinica, vol. 132, no. 1, 2009, pp. 1-6.
Rodilla E, Pérez-Lahiguera F, Costa JA, et al. Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients. Med Clin (Barc). 2009;132(1):1-6.
Rodilla, E., Pérez-Lahiguera, F., Costa, J. A., González, C., Miralles, A., Moral, D., & Pascual, J. M. (2009). Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients. Medicina Clinica, 132(1), 1-6. https://doi.org/10.1016/j.medcli.2008.07.008
Rodilla E, et al. Association Between Serum Uric Acid, Metabolic Syndrome and Microalbuminuria in Previously Untreated Essential Hypertensive Patients. Med Clin (Barc). 2009 Jan 17;132(1):1-6. PubMed PMID: 19174057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients. AU - Rodilla,Enrique, AU - Pérez-Lahiguera,Francisco, AU - Costa,José A, AU - González,Carmen, AU - Miralles,Amparo, AU - Moral,Desamparados, AU - Pascual,José María, Y1 - 2008/12/03/ PY - 2008/03/26/received PY - 2008/07/02/accepted PY - 2009/1/29/entrez PY - 2009/1/29/pubmed PY - 2009/6/23/medline SP - 1 EP - 6 JF - Medicina clinica JO - Med Clin (Barc) VL - 132 IS - 1 N2 - BACKGROUND AND OBJECTIVE: The aim of the study was to assess the association of serum uric acid levels with microalbuminuria -urinary albumin excretion (UAE)> or = 30mg/24h-. PATIENTS AND METHOD: Cross-sectional study in 429 (220 women) hypertensive, non diabetic, never treated patients (mean age: 47 years) with glomerular filtration rate > or =60ml/min/1.73m(2). RESULTS: The prevalence of microalbuminuria was 20.5%; 18% had hyperuricemia and 47% fulfilled the criteria for metabolic syndrome (MS). Baseline UAE correlated in the unvaried analysis to diastolic blood pressure, waist circumference, high-density lipoprotein cholesterol and uric acid. In multiple linear regression models, only MS (beta=0.113; p=0.03), and serum uric acid values (beta=0.04; p=0.05) were independently associated with logUAE, after adjustment for age and sex. Hyperuricemia (serum uric acid level > or =7.0mg/dl for men and > or =6.5mg/dl for women; odds ratio=2.18; 95% confidence interval, 1.21-3.92; p=0.010), and MS (odds ratio=2.16; 95% confidence interval, 1.32-3.53; p=0.002) were independently associated with a higher risk of microalbuminuria in multiple logistic regression analyses. The prevalence of microalbuminuria was 45.8% in patients with coexistent MS and hyperuricemia, as compared to 13.6% in hypertensive patients without it (p<0.001). In patients with concomitant MS and hyperuricemia the probability of being microalbuminuric was 3.7 times higher than in patients without those factors. CONCLUSION: Serum uric acid level is associated with microalbuminuria. Coexistence of MS and hyperuricemia in hypertensive patients increases almost 4 times the odds of being microalbuminuric. SN - 0025-7753 UR - https://www.unboundmedicine.com/medline/citation/19174057/Association_between_serum_uric_acid_metabolic_syndrome_and_microalbuminuria_in_previously_untreated_essential_hypertensive_patients_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0025-7753/132/1 DB - PRIME DP - Unbound Medicine ER -