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Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery.
Pharmacology. 2009; 83(4):205-10.P

Abstract

INTRODUCTION

In this prospective, randomized, and double-blinded study we investigated the efficacy of haloperidol (10 microg/kg) and the combination of haloperidol (10 microg/kg) with ondansetron (0.1 mg/kg) for the prophylaxis of postoperative nausea and vomiting (PONV) after ophthalmologic surgery.

METHODS

60 patients (ASA status 1-3) with risk factors for PONV (female, non-smoker, motion sickness or PONV in history, opioids for postoperative analgesia) undergoing retinal or strabismus surgery were included into the study and randomised to the haloperidol group (H-Group) or the haloperidol-ondansetron group (H/O-Group). 20 min before the end of anaesthesia the study medication was given. Nausea, vomiting, pain scores, and adverse events were assessed postoperatively over 24 h.

RESULTS

The incidence of PONV was lower for the H/O-Group (23 vs. 57% for the H-Group). Especially the incidence of vomiting was reduced for the H/O-Group (7 vs. 27% in the H-Group). No significant differences could be detected regarding adverse events.

CONCLUSION

The single use of haloperidol for the prophylaxis of PONV is doubtful. Better results were obtained with the combination therapy of haloperidol with ondansetron, especially for vomiting.

Authors+Show Affiliations

Department of Anaesthesiology, University of Cologne, Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19174617

Citation

Dagtekin, Oguzhan, et al. "Haloperidol Versus Haloperidol Plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting After Ophthalmologic Surgery." Pharmacology, vol. 83, no. 4, 2009, pp. 205-10.
Dagtekin O, Wiese P, Wolter K, et al. Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery. Pharmacology. 2009;83(4):205-10.
Dagtekin, O., Wiese, P., Wolter, K., Hermann, M. M., Pietruck, C., & Kampe, S. (2009). Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery. Pharmacology, 83(4), 205-10. https://doi.org/10.1159/000196812
Dagtekin O, et al. Haloperidol Versus Haloperidol Plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting After Ophthalmologic Surgery. Pharmacology. 2009;83(4):205-10. PubMed PMID: 19174617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery. AU - Dagtekin,Oguzhan, AU - Wiese,Philip, AU - Wolter,Karsten, AU - Hermann,Manuel M, AU - Pietruck,Christian, AU - Kampe,Sandra, Y1 - 2009/01/28/ PY - 2008/10/20/received PY - 2008/11/02/accepted PY - 2009/1/29/entrez PY - 2009/1/29/pubmed PY - 2009/6/3/medline SP - 205 EP - 10 JF - Pharmacology JO - Pharmacology VL - 83 IS - 4 N2 - INTRODUCTION: In this prospective, randomized, and double-blinded study we investigated the efficacy of haloperidol (10 microg/kg) and the combination of haloperidol (10 microg/kg) with ondansetron (0.1 mg/kg) for the prophylaxis of postoperative nausea and vomiting (PONV) after ophthalmologic surgery. METHODS: 60 patients (ASA status 1-3) with risk factors for PONV (female, non-smoker, motion sickness or PONV in history, opioids for postoperative analgesia) undergoing retinal or strabismus surgery were included into the study and randomised to the haloperidol group (H-Group) or the haloperidol-ondansetron group (H/O-Group). 20 min before the end of anaesthesia the study medication was given. Nausea, vomiting, pain scores, and adverse events were assessed postoperatively over 24 h. RESULTS: The incidence of PONV was lower for the H/O-Group (23 vs. 57% for the H-Group). Especially the incidence of vomiting was reduced for the H/O-Group (7 vs. 27% in the H-Group). No significant differences could be detected regarding adverse events. CONCLUSION: The single use of haloperidol for the prophylaxis of PONV is doubtful. Better results were obtained with the combination therapy of haloperidol with ondansetron, especially for vomiting. SN - 1423-0313 UR - https://www.unboundmedicine.com/medline/citation/19174617/Haloperidol_versus_haloperidol_plus_ondansetron_for_the_prophylaxis_of_postoperative_nausea_and_vomiting_after_ophthalmologic_surgery_ DB - PRIME DP - Unbound Medicine ER -