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A low-GI diet is associated with a short-term improvement of glycaemic control in Asian patients with type 2 diabetes.
Diabetes Obes Metab 2009; 11(4):387-96DO

Abstract

AIMS

The aim of this study is to compare the efficacy of low glycaemic index (GI) vs. conventional carbohydrate exchange (CCE) dietary advice on glycaemic control and metabolic parameters in patients with type 2 diabetes.

METHODS

A total of 104 patients with type 2 diabetes were randomly assigned to either a low GI (GI) or CCE dietary advice over a 12-week period. The primary end-point was glycaemic control as assessed by glycated haemoglobin A1c (HbA1c), fructosamine level and plasma glucose. The secondary end-points were anthropometric measurements and metabolic parameters that include blood pressure, lipid profile and insulin levels. The oral antidiabetic medications remained unchanged throughout the duration of the study.

RESULTS

A low-GI diet was associated with significant changes in the fructosamine level (DeltaGI = -0.20 +/- 0.03; DeltaCCE = -0.08 +/- 0.03 mmol/l, p < 0.01) and waist circumference (DeltaGI group = -1.88 +/- 0.30 cm; DeltaCCE group: -0.36 +/- 0.4 cm, p < 0.05) at week 4. At week 12, the changes in fasting glucose (DeltaGI = -0.03 +/- 0.3; DeltaCCE = 0.7 +/- 0.3 mmol/l; p < 0.05) and waist circumference (DeltaGI = -2.35 +/- 0.47 cm; DeltaCCE group = -0.66 +/- 0.46 cm; p < 0.05) in the GI group was significantly lower than the CCE group. With the low-GI diet, the changes in postprandial glycaemia at time 0, 60, 150 and 180 min after consuming the standard test meal was lower than with the CCE diet (p < 0.05). No significant differences were found between the groups for the remaining parameters that were measured.

CONCLUSIONS

Use of a low-GI diet resulted in significant changes of serum fructosamine level, plasma glucose and waist circumference in Asian patients with type 2 diabetes over a 12-week period compared with those following a CCE diet. The effect on HbA1c and other metabolic parameters was not significantly different between the two study groups but the improvement within the GI group was more pronounced and of clinical benefit.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang Selangor, Malaysia. bnisak@medic.upm.edu.myNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19175374

Citation

Yusof, B N M., et al. "A low-GI Diet Is Associated With a Short-term Improvement of Glycaemic Control in Asian Patients With Type 2 Diabetes." Diabetes, Obesity & Metabolism, vol. 11, no. 4, 2009, pp. 387-96.
Yusof BN, Talib RA, Kamaruddin NA, et al. A low-GI diet is associated with a short-term improvement of glycaemic control in Asian patients with type 2 diabetes. Diabetes Obes Metab. 2009;11(4):387-96.
Yusof, B. N., Talib, R. A., Kamaruddin, N. A., Karim, N. A., Chinna, K., & Gilbertson, H. (2009). A low-GI diet is associated with a short-term improvement of glycaemic control in Asian patients with type 2 diabetes. Diabetes, Obesity & Metabolism, 11(4), pp. 387-96. doi:10.1111/j.1463-1326.2008.00984.x.
Yusof BN, et al. A low-GI Diet Is Associated With a Short-term Improvement of Glycaemic Control in Asian Patients With Type 2 Diabetes. Diabetes Obes Metab. 2009;11(4):387-96. PubMed PMID: 19175374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A low-GI diet is associated with a short-term improvement of glycaemic control in Asian patients with type 2 diabetes. AU - Yusof,B N M, AU - Talib,R A, AU - Kamaruddin,N A, AU - Karim,N A, AU - Chinna,K, AU - Gilbertson,H, Y1 - 2009/01/19/ PY - 2009/1/30/entrez PY - 2009/1/30/pubmed PY - 2010/1/23/medline SP - 387 EP - 96 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 11 IS - 4 N2 - AIMS: The aim of this study is to compare the efficacy of low glycaemic index (GI) vs. conventional carbohydrate exchange (CCE) dietary advice on glycaemic control and metabolic parameters in patients with type 2 diabetes. METHODS: A total of 104 patients with type 2 diabetes were randomly assigned to either a low GI (GI) or CCE dietary advice over a 12-week period. The primary end-point was glycaemic control as assessed by glycated haemoglobin A1c (HbA1c), fructosamine level and plasma glucose. The secondary end-points were anthropometric measurements and metabolic parameters that include blood pressure, lipid profile and insulin levels. The oral antidiabetic medications remained unchanged throughout the duration of the study. RESULTS: A low-GI diet was associated with significant changes in the fructosamine level (DeltaGI = -0.20 +/- 0.03; DeltaCCE = -0.08 +/- 0.03 mmol/l, p < 0.01) and waist circumference (DeltaGI group = -1.88 +/- 0.30 cm; DeltaCCE group: -0.36 +/- 0.4 cm, p < 0.05) at week 4. At week 12, the changes in fasting glucose (DeltaGI = -0.03 +/- 0.3; DeltaCCE = 0.7 +/- 0.3 mmol/l; p < 0.05) and waist circumference (DeltaGI = -2.35 +/- 0.47 cm; DeltaCCE group = -0.66 +/- 0.46 cm; p < 0.05) in the GI group was significantly lower than the CCE group. With the low-GI diet, the changes in postprandial glycaemia at time 0, 60, 150 and 180 min after consuming the standard test meal was lower than with the CCE diet (p < 0.05). No significant differences were found between the groups for the remaining parameters that were measured. CONCLUSIONS: Use of a low-GI diet resulted in significant changes of serum fructosamine level, plasma glucose and waist circumference in Asian patients with type 2 diabetes over a 12-week period compared with those following a CCE diet. The effect on HbA1c and other metabolic parameters was not significantly different between the two study groups but the improvement within the GI group was more pronounced and of clinical benefit. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/19175374/A_low_GI_diet_is_associated_with_a_short_term_improvement_of_glycaemic_control_in_Asian_patients_with_type_2_diabetes_ L2 - https://doi.org/10.1111/j.1463-1326.2008.00984.x DB - PRIME DP - Unbound Medicine ER -