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Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children.
Br J Nutr. 2009 Aug; 102(3):407-12.BJ

Abstract

Animal studies have shown that fatty acids (FA) are important for normal bone development. Human data are scanty and mostly related to diseases. We hypothesised that serum FA pattern might be related to bone mineralisation in healthy children. Serum phospholipid FA pattern was studied in relation to bone parameters in eighty-five healthy Caucasian 8-year-olds. Dual-energy X-ray absorptiometry and blood sampling for analysis of serum phospholipid FA by capillary GLC were performed on the same day. SFA concentrations were associated with bone mineral density (BMD) of the hip, lumbar spine and total body. There was a general trend that linoleic acid (LA; 18 : 2n-6) was negatively associated with BMD, since that was found both for the LA concentration, the total n-6 concentration and the ratio of n-6:n-3 FA. Arachidonic acid (AA; 20 : 4n-6) was positively correlated with bone mineral content (BMC) and BMD of total body, as was the corresponding z-score and the AA:LA ratio. Both saturated and polyunsaturated serum phospholipid FA were associated with BMC and BMD in healthy children. LA and AA were found to inversely influence bone mineralisation and the association with the n-6:n-3 ratio suggested that this balance might also be of importance. The general trend of a negative influence of high n-6 FA concentrations on bone mineralisation might be of concern in relation to the changes in the Western diet. Longitudinal studies are necessary to verify if different bone compartments and different grades of modelling are related to different FA patterns.

Authors+Show Affiliations

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. susanne-e-sson@bredband.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19175947

Citation

Eriksson, Susanne, et al. "Fatty Acid Pattern in Serum Is Associated With Bone Mineralisation in Healthy 8-year-old Children." The British Journal of Nutrition, vol. 102, no. 3, 2009, pp. 407-12.
Eriksson S, Mellström D, Strandvik B. Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. Br J Nutr. 2009;102(3):407-12.
Eriksson, S., Mellström, D., & Strandvik, B. (2009). Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. The British Journal of Nutrition, 102(3), 407-12. https://doi.org/10.1017/S0007114508190286
Eriksson S, Mellström D, Strandvik B. Fatty Acid Pattern in Serum Is Associated With Bone Mineralisation in Healthy 8-year-old Children. Br J Nutr. 2009;102(3):407-12. PubMed PMID: 19175947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. AU - Eriksson,Susanne, AU - Mellström,Dan, AU - Strandvik,Birgitta, Y1 - 2009/01/28/ PY - 2009/1/30/entrez PY - 2009/1/30/pubmed PY - 2009/9/11/medline SP - 407 EP - 12 JF - The British journal of nutrition JO - Br J Nutr VL - 102 IS - 3 N2 - Animal studies have shown that fatty acids (FA) are important for normal bone development. Human data are scanty and mostly related to diseases. We hypothesised that serum FA pattern might be related to bone mineralisation in healthy children. Serum phospholipid FA pattern was studied in relation to bone parameters in eighty-five healthy Caucasian 8-year-olds. Dual-energy X-ray absorptiometry and blood sampling for analysis of serum phospholipid FA by capillary GLC were performed on the same day. SFA concentrations were associated with bone mineral density (BMD) of the hip, lumbar spine and total body. There was a general trend that linoleic acid (LA; 18 : 2n-6) was negatively associated with BMD, since that was found both for the LA concentration, the total n-6 concentration and the ratio of n-6:n-3 FA. Arachidonic acid (AA; 20 : 4n-6) was positively correlated with bone mineral content (BMC) and BMD of total body, as was the corresponding z-score and the AA:LA ratio. Both saturated and polyunsaturated serum phospholipid FA were associated with BMC and BMD in healthy children. LA and AA were found to inversely influence bone mineralisation and the association with the n-6:n-3 ratio suggested that this balance might also be of importance. The general trend of a negative influence of high n-6 FA concentrations on bone mineralisation might be of concern in relation to the changes in the Western diet. Longitudinal studies are necessary to verify if different bone compartments and different grades of modelling are related to different FA patterns. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19175947/Fatty_acid_pattern_in_serum_is_associated_with_bone_mineralisation_in_healthy_8_year_old_children_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508190286/type/journal_article DB - PRIME DP - Unbound Medicine ER -