Tags

Type your tag names separated by a space and hit enter

Protease-activated receptors, apoptosis and tumor growth.
Pathophysiol Haemost Thromb. 2008; 36(3-4):137-47.PH

Abstract

Protease-activated receptors (PARs) are G-protein-coupled receptors (GPCRs) that are activated by a unique proteolytic mechanism. Besides the important role of blood coagulation factors in preventing bleeding after vascular injury, these serine proteinases actively engage target cells thereby fulfilling critical functions in cell biology. Cellular responses triggered by coagulation factor-induced PAR activation suggest that PARs play an important role in proliferation, survival and/or malignant transformation of tumor cells. Indeed, PAR expression correlates with cancer malignancy and clinical studies show that anticoagulant treatment is beneficial in cancer patients. In this review, we provide an overview on the PAR family, their mode of activation and mechanisms by which PAR signaling is terminated. In addition, we discuss the relationship between blood coagulation and cancer biology focusing on the potential role of PAR-induced modulation of cell survival, apoptosis and tumor growth.

Authors+Show Affiliations

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. K.S.Borensztajn@amc.uva.nlNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19176987

Citation

Borensztajn, Keren S., and C Arnold Spek. "Protease-activated Receptors, Apoptosis and Tumor Growth." Pathophysiology of Haemostasis and Thrombosis, vol. 36, no. 3-4, 2008, pp. 137-47.
Borensztajn KS, Spek CA. Protease-activated receptors, apoptosis and tumor growth. Pathophysiol Haemost Thromb. 2008;36(3-4):137-47.
Borensztajn, K. S., & Spek, C. A. (2008). Protease-activated receptors, apoptosis and tumor growth. Pathophysiology of Haemostasis and Thrombosis, 36(3-4), 137-47. https://doi.org/10.1159/000175152
Borensztajn KS, Spek CA. Protease-activated Receptors, Apoptosis and Tumor Growth. Pathophysiol Haemost Thromb. 2008;36(3-4):137-47. PubMed PMID: 19176987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protease-activated receptors, apoptosis and tumor growth. AU - Borensztajn,Keren S, AU - Spek,C Arnold, Y1 - 2009/01/27/ PY - 2009/1/30/entrez PY - 2009/1/30/pubmed PY - 2009/3/3/medline SP - 137 EP - 47 JF - Pathophysiology of haemostasis and thrombosis JO - Pathophysiol Haemost Thromb VL - 36 IS - 3-4 N2 - Protease-activated receptors (PARs) are G-protein-coupled receptors (GPCRs) that are activated by a unique proteolytic mechanism. Besides the important role of blood coagulation factors in preventing bleeding after vascular injury, these serine proteinases actively engage target cells thereby fulfilling critical functions in cell biology. Cellular responses triggered by coagulation factor-induced PAR activation suggest that PARs play an important role in proliferation, survival and/or malignant transformation of tumor cells. Indeed, PAR expression correlates with cancer malignancy and clinical studies show that anticoagulant treatment is beneficial in cancer patients. In this review, we provide an overview on the PAR family, their mode of activation and mechanisms by which PAR signaling is terminated. In addition, we discuss the relationship between blood coagulation and cancer biology focusing on the potential role of PAR-induced modulation of cell survival, apoptosis and tumor growth. SN - 1424-8840 UR - https://www.unboundmedicine.com/medline/citation/19176987/Protease_activated_receptors_apoptosis_and_tumor_growth_ L2 - https://www.karger.com?DOI=10.1159/000175152 DB - PRIME DP - Unbound Medicine ER -