Tags

Type your tag names separated by a space and hit enter

Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study.
Arthritis Rheum 2009; 61(2):225-32AR

Abstract

OBJECTIVE

The association between hyperuricemia and cardiovascular events has been documented in high-risk groups, but is still undetermined in general populations, especially Chinese. This study assessed the temporal association between serum uric acid level, hyperuricemia, and cardiovascular mortality.

METHODS

A prospective cohort study of 41,879 men and 48,514 women ages > or = 35 years was conducted using data from the MJ Health Screening Centers in Taiwan. Mortality from all causes, total cardiovascular disease (CVD), ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels.

RESULTS

A total of 1,151 (21.2%) events of 5,427 total deaths were ascribed to CVD (mean followup 8.2 years). Hazard ratios (HRs) for hyperuricemia (serum uric acid level >7 mg/dl) were estimated with Cox regression model after adjusting for age, sex, body mass index, cholesterol, triglycerides, diabetes, hypertension, heavy cigarette smoking, and frequent alcohol consumption. In all patients, HRs were 1.16 (P < 0.001) for all-cause mortality, 1.39 (P < 0.001) for total CVD, and 1.35 (P = 0.02) for ischemic stroke. In subgroup analysis, the HRs for cardiovascular risk remained significant in patients with hypertension (1.44, P < 0.001) and in patients with diabetes (1.64, P < 0.001). In addition, in a low metabolic risk subgroup, the HRs for all-cause mortality and total cardiovascular morbidity were 1.24 (P = 0.02) and 1.48 (P = 0.16), respectively.

CONCLUSION

Hyperuricemia was an independent risk factor of mortality from all causes, total CVD, and ischemic stroke in the Taiwanese general population, in high-risk groups, and potentially in low-risk groups.

Authors+Show Affiliations

China Medical University Hospital, Taichung, and National Taiwan University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19177541

Citation

Chen, Jiunn-Horng, et al. "Serum Uric Acid Level as an Independent Risk Factor for All-cause, Cardiovascular, and Ischemic Stroke Mortality: a Chinese Cohort Study." Arthritis and Rheumatism, vol. 61, no. 2, 2009, pp. 225-32.
Chen JH, Chuang SY, Chen HJ, et al. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum. 2009;61(2):225-32.
Chen, J. H., Chuang, S. Y., Chen, H. J., Yeh, W. T., & Pan, W. H. (2009). Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis and Rheumatism, 61(2), pp. 225-32. doi:10.1002/art.24164.
Chen JH, et al. Serum Uric Acid Level as an Independent Risk Factor for All-cause, Cardiovascular, and Ischemic Stroke Mortality: a Chinese Cohort Study. Arthritis Rheum. 2009 Feb 15;61(2):225-32. PubMed PMID: 19177541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. AU - Chen,Jiunn-Horng, AU - Chuang,Shao-Yuan, AU - Chen,Hsin-Jen, AU - Yeh,Wen-Ting, AU - Pan,Wen-Harn, PY - 2009/1/30/entrez PY - 2009/1/30/pubmed PY - 2009/4/15/medline SP - 225 EP - 32 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 61 IS - 2 N2 - OBJECTIVE: The association between hyperuricemia and cardiovascular events has been documented in high-risk groups, but is still undetermined in general populations, especially Chinese. This study assessed the temporal association between serum uric acid level, hyperuricemia, and cardiovascular mortality. METHODS: A prospective cohort study of 41,879 men and 48,514 women ages > or = 35 years was conducted using data from the MJ Health Screening Centers in Taiwan. Mortality from all causes, total cardiovascular disease (CVD), ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels. RESULTS: A total of 1,151 (21.2%) events of 5,427 total deaths were ascribed to CVD (mean followup 8.2 years). Hazard ratios (HRs) for hyperuricemia (serum uric acid level >7 mg/dl) were estimated with Cox regression model after adjusting for age, sex, body mass index, cholesterol, triglycerides, diabetes, hypertension, heavy cigarette smoking, and frequent alcohol consumption. In all patients, HRs were 1.16 (P < 0.001) for all-cause mortality, 1.39 (P < 0.001) for total CVD, and 1.35 (P = 0.02) for ischemic stroke. In subgroup analysis, the HRs for cardiovascular risk remained significant in patients with hypertension (1.44, P < 0.001) and in patients with diabetes (1.64, P < 0.001). In addition, in a low metabolic risk subgroup, the HRs for all-cause mortality and total cardiovascular morbidity were 1.24 (P = 0.02) and 1.48 (P = 0.16), respectively. CONCLUSION: Hyperuricemia was an independent risk factor of mortality from all causes, total CVD, and ischemic stroke in the Taiwanese general population, in high-risk groups, and potentially in low-risk groups. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/19177541/Serum_uric_acid_level_as_an_independent_risk_factor_for_all_cause_cardiovascular_and_ischemic_stroke_mortality:_a_Chinese_cohort_study_ L2 - https://doi.org/10.1002/art.24164 DB - PRIME DP - Unbound Medicine ER -