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PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.
Clin Endocrinol (Oxf). 2009 Sep; 71(3):341-5.CE

Abstract

OBJECTIVE

The Ala allele of the Pro12Ala polymorphism (rs1801282) of peroxisome proliferator-activated receptor gamma (PPARgamma) is protective against type 2 diabetes (T2DM). Resistin, secreted from adipocytes, causes insulin resistance in rodents. Resistin gene expression is reduced by the PPARgamma ligand. We previously reported that subjects with the G/G genotype of a resistin gene single nucleotide polymorphism (SNP) at -420 (rs1862513) had the highest circulating resistin levels, followed by C/G and C/C. The aim of this study was to determine the relationship among PPARgamma Pro12Ala polymorphism, resistin SNP-420, and plasma resistin.

DESIGN, PATIENTS AND MEASUREMENTS

We cross-sectionally analysed 2077 community-dwelling subjects attending an annual medical check-up. Genotypes were determined by TaqMan analysis. Fasting plasma resistin was measured using ELISA.

RESULTS

Plasma resistin appeared to be higher in subjects with the Pro/Pro genotype of PPARgamma than those with Pro/Ala and Ala/Ala genotypes (mean +/- SE, 11.6 +/- 0.2 vs. 10.4 +/- 0.5 microg/l). Multiple regression analysis, adjusted for age, gender, BMI, and resistin SNP-420, revealed that the Pro/Pro genotype was a positive predictor of plasma resistin (PPARgamma , Pro/Pro vs. Pro/Ala + Ala/Ala, unstandardized regression coefficient (beta) = 1.03, P = 0.0384). The effects of the Pro/Pro genotype of PPARgamma (Pro/Pro vs. Pro/Ala + Ala/Ala) and the G/G genotype of resistin SNP-420 (G/G vs. C/C) on plasma resistin were synergistic (beta = 4.76, P = 0.011).

CONCLUSIONS

The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes were synergistically associated with plasma resistin, when adjusted for age, gender, and BMI, in the Japanese general population.

Authors+Show Affiliations

Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. harosawa@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19178525

Citation

Osawa, Haruhiko, et al. "PPARgamma Pro12Ala Pro/Pro and Resistin SNP-420 G/G Genotypes Are Synergistically Associated With Plasma Resistin in the Japanese General Population." Clinical Endocrinology, vol. 71, no. 3, 2009, pp. 341-5.
Osawa H, Tabara Y, Kawamoto R, et al. PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. Clin Endocrinol (Oxf). 2009;71(3):341-5.
Osawa, H., Tabara, Y., Kawamoto, R., Ohashi, J., Ochi, M., Onuma, H., Nishida, W., Yamada, K., Nakura, J., Miki, T., Makino, H., & Kohara, K. (2009). PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. Clinical Endocrinology, 71(3), 341-5. https://doi.org/10.1111/j.1365-2265.2008.03465.x
Osawa H, et al. PPARgamma Pro12Ala Pro/Pro and Resistin SNP-420 G/G Genotypes Are Synergistically Associated With Plasma Resistin in the Japanese General Population. Clin Endocrinol (Oxf). 2009;71(3):341-5. PubMed PMID: 19178525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. AU - Osawa,Haruhiko, AU - Tabara,Yasuharu, AU - Kawamoto,Ryuichi, AU - Ohashi,Jun, AU - Ochi,Masaaki, AU - Onuma,Hiroshi, AU - Nishida,Wataru, AU - Yamada,Kazuya, AU - Nakura,Jun, AU - Miki,Tetsuro, AU - Makino,Hideichi, AU - Kohara,Katsuhiko, Y1 - 2008/10/30/ PY - 2009/1/31/entrez PY - 2009/1/31/pubmed PY - 2009/10/20/medline SP - 341 EP - 5 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 71 IS - 3 N2 - OBJECTIVE: The Ala allele of the Pro12Ala polymorphism (rs1801282) of peroxisome proliferator-activated receptor gamma (PPARgamma) is protective against type 2 diabetes (T2DM). Resistin, secreted from adipocytes, causes insulin resistance in rodents. Resistin gene expression is reduced by the PPARgamma ligand. We previously reported that subjects with the G/G genotype of a resistin gene single nucleotide polymorphism (SNP) at -420 (rs1862513) had the highest circulating resistin levels, followed by C/G and C/C. The aim of this study was to determine the relationship among PPARgamma Pro12Ala polymorphism, resistin SNP-420, and plasma resistin. DESIGN, PATIENTS AND MEASUREMENTS: We cross-sectionally analysed 2077 community-dwelling subjects attending an annual medical check-up. Genotypes were determined by TaqMan analysis. Fasting plasma resistin was measured using ELISA. RESULTS: Plasma resistin appeared to be higher in subjects with the Pro/Pro genotype of PPARgamma than those with Pro/Ala and Ala/Ala genotypes (mean +/- SE, 11.6 +/- 0.2 vs. 10.4 +/- 0.5 microg/l). Multiple regression analysis, adjusted for age, gender, BMI, and resistin SNP-420, revealed that the Pro/Pro genotype was a positive predictor of plasma resistin (PPARgamma , Pro/Pro vs. Pro/Ala + Ala/Ala, unstandardized regression coefficient (beta) = 1.03, P = 0.0384). The effects of the Pro/Pro genotype of PPARgamma (Pro/Pro vs. Pro/Ala + Ala/Ala) and the G/G genotype of resistin SNP-420 (G/G vs. C/C) on plasma resistin were synergistic (beta = 4.76, P = 0.011). CONCLUSIONS: The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes were synergistically associated with plasma resistin, when adjusted for age, gender, and BMI, in the Japanese general population. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/19178525/PPARgamma_Pro12Ala_Pro/Pro_and_resistin_SNP_420_G/G_genotypes_are_synergistically_associated_with_plasma_resistin_in_the_Japanese_general_population_ L2 - https://doi.org/10.1111/j.1365-2265.2008.03465.x DB - PRIME DP - Unbound Medicine ER -