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Effect of an OT antagonist on the control of the midcycle LH surge in women.
Clin Endocrinol (Oxf). 2009 Jul; 71(1):100-3.CE

Abstract

OBJECTIVE

Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge.

DESIGN

Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16-17 mm (Group 1) or 18-19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle-1) or atosiban (cycle-2).

PATIENTS

Fifteen women (10 in group 1 and 5 in group 2) aged 23-35 years.

MEASUREMENTS

Blood samples were obtained every 6 h to characterize the midcycle LH surge.

RESULTS

The time interval (mean +/- SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46.8 +/- 4.8 and 45.6 +/- 9.6 h in group 1 and 6.0 +/- 2.4 and 7.5 +/- 2.8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle-2 (41.2 +/- 4.6 mIU/ml) was significantly lower than in cycle-1 (52.8 +/- 3.4 mIU/ml, P < 0.05). Nevertheless, in each group, the area under the curve for LH was similar in the two cycles.

CONCLUSIONS

Antagonism of endogenous OT action by atosiban does not alter the LH profile during a fully characterized midcycle LH surge, suggesting that OT is not a major regulator of LH secretion in women.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Medical School, University of Thessalia, Larissa, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19178530

Citation

Vanakara, P, et al. "Effect of an OT Antagonist On the Control of the Midcycle LH Surge in Women." Clinical Endocrinology, vol. 71, no. 1, 2009, pp. 100-3.
Vanakara P, Dafopoulos K, Papastergiopoulou L, et al. Effect of an OT antagonist on the control of the midcycle LH surge in women. Clin Endocrinol (Oxf). 2009;71(1):100-3.
Vanakara, P., Dafopoulos, K., Papastergiopoulou, L., Kallitsaris, A., Papageorgiou, I., & Messinis, I. E. (2009). Effect of an OT antagonist on the control of the midcycle LH surge in women. Clinical Endocrinology, 71(1), 100-3. https://doi.org/10.1111/j.1365-2265.2008.03456.x
Vanakara P, et al. Effect of an OT Antagonist On the Control of the Midcycle LH Surge in Women. Clin Endocrinol (Oxf). 2009;71(1):100-3. PubMed PMID: 19178530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of an OT antagonist on the control of the midcycle LH surge in women. AU - Vanakara,P, AU - Dafopoulos,K, AU - Papastergiopoulou,L, AU - Kallitsaris,A, AU - Papageorgiou,I, AU - Messinis,I E, Y1 - 2008/10/26/ PY - 2009/1/31/entrez PY - 2009/1/31/pubmed PY - 2009/10/14/medline SP - 100 EP - 3 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 71 IS - 1 N2 - OBJECTIVE: Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN: Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16-17 mm (Group 1) or 18-19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle-1) or atosiban (cycle-2). PATIENTS: Fifteen women (10 in group 1 and 5 in group 2) aged 23-35 years. MEASUREMENTS: Blood samples were obtained every 6 h to characterize the midcycle LH surge. RESULTS: The time interval (mean +/- SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46.8 +/- 4.8 and 45.6 +/- 9.6 h in group 1 and 6.0 +/- 2.4 and 7.5 +/- 2.8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle-2 (41.2 +/- 4.6 mIU/ml) was significantly lower than in cycle-1 (52.8 +/- 3.4 mIU/ml, P < 0.05). Nevertheless, in each group, the area under the curve for LH was similar in the two cycles. CONCLUSIONS: Antagonism of endogenous OT action by atosiban does not alter the LH profile during a fully characterized midcycle LH surge, suggesting that OT is not a major regulator of LH secretion in women. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/19178530/Effect_of_an_OT_antagonist_on_the_control_of_the_midcycle_LH_surge_in_women_ L2 - https://doi.org/10.1111/j.1365-2265.2008.03456.x DB - PRIME DP - Unbound Medicine ER -