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Prognostic value of estrogen receptor and progesterone receptor status in young Chinese ovarian carcinoma patients.
Gynecol Oncol. 2009 Apr; 113(1):99-104.GO

Abstract

OBJECTIVE

The purpose of this study was to investigate the expression patterns and prognostic impact of estrogen receptor (ER), progesterone receptor (PR) and their combinations in young patients with ovarian carcinomas (OC) in China.

METHODS

We collected data on 86 patients diagnosed of OC younger than or equal to 40 years of age with a long clinical follow-up. Immunohistochemical staining was performed to assess ER and PR expression in paraffin-embedded ovarian cancers. Samples in which more than 10% of cells showed stained nuclei were interpreted as positive for the particular receptor. Survival rates (Kaplan-Meier method) were compared by the log rank test. A multivariate analysis (Cox proportional hazards) was used to determine the independent effect of each variable on survival.

RESULTS

ER were found positive in 64.0% of all cases but most highly expressed in serous types (P=0.047). PR-positive expression accounted for 57.0% of all cases and elevated in early FIGO stages and well-differentiated diseases (P=0.004 and 0.012, respectively). The expression of PR, but not ER, was associated with favorable survival in Kaplan-Meier survival analyses (P<0.001). The ER+PR+ combination, which was associated with low FIGO stages (P=0.012) and low tumor grade (P=0.046), showed a superior course of patients' overall survival compared with all other combinations (5-year survival rate 95.0% vs. 73.4%, log rank P=0.001). PR status (hazard ratio 1.93, P<0.001) together with FIGO stage (hazard ratio 2.19, P<0.001) were proved to be independent prognostic factors by multivariate analysis.

CONCLUSIONS

This study indicates that the expression of PR, especially the ER+PR+ phenotype predicts a favorable clinical outcome for young patients of OC.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Sichuan, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19178934

Citation

Yang, Xiao-Yun, et al. "Prognostic Value of Estrogen Receptor and Progesterone Receptor Status in Young Chinese Ovarian Carcinoma Patients." Gynecologic Oncology, vol. 113, no. 1, 2009, pp. 99-104.
Yang XY, Xi MR, Yang KX, et al. Prognostic value of estrogen receptor and progesterone receptor status in young Chinese ovarian carcinoma patients. Gynecol Oncol. 2009;113(1):99-104.
Yang, X. Y., Xi, M. R., Yang, K. X., & Yu, H. (2009). Prognostic value of estrogen receptor and progesterone receptor status in young Chinese ovarian carcinoma patients. Gynecologic Oncology, 113(1), 99-104. https://doi.org/10.1016/j.ygyno.2008.12.018
Yang XY, et al. Prognostic Value of Estrogen Receptor and Progesterone Receptor Status in Young Chinese Ovarian Carcinoma Patients. Gynecol Oncol. 2009;113(1):99-104. PubMed PMID: 19178934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic value of estrogen receptor and progesterone receptor status in young Chinese ovarian carcinoma patients. AU - Yang,Xiao-Yun, AU - Xi,Ming-Rong, AU - Yang,Kai-Xuan, AU - Yu,Hai, Y1 - 2009/01/29/ PY - 2008/08/06/received PY - 2008/12/01/revised PY - 2008/12/04/accepted PY - 2009/1/31/entrez PY - 2009/1/31/pubmed PY - 2009/3/27/medline SP - 99 EP - 104 JF - Gynecologic oncology JO - Gynecol Oncol VL - 113 IS - 1 N2 - OBJECTIVE: The purpose of this study was to investigate the expression patterns and prognostic impact of estrogen receptor (ER), progesterone receptor (PR) and their combinations in young patients with ovarian carcinomas (OC) in China. METHODS: We collected data on 86 patients diagnosed of OC younger than or equal to 40 years of age with a long clinical follow-up. Immunohistochemical staining was performed to assess ER and PR expression in paraffin-embedded ovarian cancers. Samples in which more than 10% of cells showed stained nuclei were interpreted as positive for the particular receptor. Survival rates (Kaplan-Meier method) were compared by the log rank test. A multivariate analysis (Cox proportional hazards) was used to determine the independent effect of each variable on survival. RESULTS: ER were found positive in 64.0% of all cases but most highly expressed in serous types (P=0.047). PR-positive expression accounted for 57.0% of all cases and elevated in early FIGO stages and well-differentiated diseases (P=0.004 and 0.012, respectively). The expression of PR, but not ER, was associated with favorable survival in Kaplan-Meier survival analyses (P<0.001). The ER+PR+ combination, which was associated with low FIGO stages (P=0.012) and low tumor grade (P=0.046), showed a superior course of patients' overall survival compared with all other combinations (5-year survival rate 95.0% vs. 73.4%, log rank P=0.001). PR status (hazard ratio 1.93, P<0.001) together with FIGO stage (hazard ratio 2.19, P<0.001) were proved to be independent prognostic factors by multivariate analysis. CONCLUSIONS: This study indicates that the expression of PR, especially the ER+PR+ phenotype predicts a favorable clinical outcome for young patients of OC. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/19178934/Prognostic_value_of_estrogen_receptor_and_progesterone_receptor_status_in_young_Chinese_ovarian_carcinoma_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(08)01052-4 DB - PRIME DP - Unbound Medicine ER -