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Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain.
Behav Pharmacol. 2009 Feb; 20(1):45-55.BP

Abstract

Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One group of animals was not pretreated with THC, whereas another group was injected with 13 daily injections of THC before memory testing in the Morris water maze. Both groups were administered with THC throughout the memory-testing phase of the experiment. THC decreased spatial memory and reversal learning, even in animals that received the THC pretreatment and were tolerant to the locomotor suppressant effects of the drug. Zif268 immunoreactivity was reduced in the CA3 of the hippocampus and in the prefrontal cortex only in non-pretreated animals, indicating that although tolerance to the effects of THC on neuronal activity was evident, cannabinoid-induced memory impairment in these animals persisted even after 24 days of exposure. This study shows that after extended administration of THC, its spatial memory-impairing effects are resistant to tolerance.

Authors+Show Affiliations

CNIC, Université de Bordeaux, CNRS UMR, Talence, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19179850

Citation

Boucher, Aurélie A., et al. "Chronic Treatment With Delta(9)-tetrahydrocannabinol Impairs Spatial Memory and Reduces Zif268 Expression in the Mouse Forebrain." Behavioural Pharmacology, vol. 20, no. 1, 2009, pp. 45-55.
Boucher AA, Vivier L, Metna-Laurent M, et al. Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. Behav Pharmacol. 2009;20(1):45-55.
Boucher, A. A., Vivier, L., Metna-Laurent, M., Brayda-Bruno, L., Mons, N., Arnold, J. C., & Micheau, J. (2009). Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. Behavioural Pharmacology, 20(1), 45-55. https://doi.org/10.1097/FBP.0b013e3283242f6a
Boucher AA, et al. Chronic Treatment With Delta(9)-tetrahydrocannabinol Impairs Spatial Memory and Reduces Zif268 Expression in the Mouse Forebrain. Behav Pharmacol. 2009;20(1):45-55. PubMed PMID: 19179850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. AU - Boucher,Aurélie A, AU - Vivier,Lucie, AU - Metna-Laurent,Mathilde, AU - Brayda-Bruno,Laurent, AU - Mons,Nicole, AU - Arnold,Jonathon C, AU - Micheau,Jacques, PY - 2009/1/31/entrez PY - 2009/1/31/pubmed PY - 2009/3/4/medline SP - 45 EP - 55 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 20 IS - 1 N2 - Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One group of animals was not pretreated with THC, whereas another group was injected with 13 daily injections of THC before memory testing in the Morris water maze. Both groups were administered with THC throughout the memory-testing phase of the experiment. THC decreased spatial memory and reversal learning, even in animals that received the THC pretreatment and were tolerant to the locomotor suppressant effects of the drug. Zif268 immunoreactivity was reduced in the CA3 of the hippocampus and in the prefrontal cortex only in non-pretreated animals, indicating that although tolerance to the effects of THC on neuronal activity was evident, cannabinoid-induced memory impairment in these animals persisted even after 24 days of exposure. This study shows that after extended administration of THC, its spatial memory-impairing effects are resistant to tolerance. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/19179850/Chronic_treatment_with_Delta_9__tetrahydrocannabinol_impairs_spatial_memory_and_reduces_zif268_expression_in_the_mouse_forebrain_ DB - PRIME DP - Unbound Medicine ER -