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Duration of untreated psychosis and proton magnetic resonance spectroscopy (1H-MRS) findings in first-episode schizophrenia.
Med Sci Monit 2009; 15(2):CR82-88MS

Abstract

BACKGROUND

The duration of untreated psychosis (DUP) is a factor associated with the natural course of schizophrenia and an independent predictor of treatment outcome. Recent studies focus on the effects of DUP on the functioning of the nervous system, but the findings are inconsistent. As proton magnetic resonance spectroscopy (1H-MRS) enables the assessment of signals from chemical compounds in vivo, it seems a useful tool to explore this problem.

MATERIAL/METHODS

In this study the relationships between DUP and 1H-MRS measurements were investigated. Thirty patients with first-episode schizophrenia and 19 controls were examined. Median DUP was 10 weeks. Voxels were positioned in the following regions of interest: the left frontal lobe, left temporal lobe, and left thalamus. The ratios of N-acetylaspartate (NAA), choline-containing compounds (Cho), myoinositol (mI), and glutamate/glutamine/GABA complex (Glx) to creatine (Cr) and the non-suppressed water signal were determined.

RESULTS

There were no significant differences between the whole group of patients and healthy subjects for the analyzed metabolite ratios in any region of interest. No differences were found between the groups of patients with short and long DUP and controls. No significant correlation was observed between DUP and metabolite ratios.

CONCLUSIONS

The results of the study may suggest that the relatively short DUP does not influence brain metabolism in first-episode schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Medical University of Bialystok, Bialystok, Poland. begal@poczta.onet.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19179972

Citation

Galińska, Beata, et al. "Duration of Untreated Psychosis and Proton Magnetic Resonance Spectroscopy (1H-MRS) Findings in First-episode Schizophrenia." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 15, no. 2, 2009, pp. CR82-88.
Galińska B, Szulc A, Tarasów E, et al. Duration of untreated psychosis and proton magnetic resonance spectroscopy (1H-MRS) findings in first-episode schizophrenia. Med Sci Monit. 2009;15(2):CR82-88.
Galińska, B., Szulc, A., Tarasów, E., Kubas, B., Dzienis, W., Czernikiewicz, A., & Walecki, J. (2009). Duration of untreated psychosis and proton magnetic resonance spectroscopy (1H-MRS) findings in first-episode schizophrenia. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 15(2), pp. CR82-88.
Galińska B, et al. Duration of Untreated Psychosis and Proton Magnetic Resonance Spectroscopy (1H-MRS) Findings in First-episode Schizophrenia. Med Sci Monit. 2009;15(2):CR82-88. PubMed PMID: 19179972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis and proton magnetic resonance spectroscopy (1H-MRS) findings in first-episode schizophrenia. AU - Galińska,Beata, AU - Szulc,Agata, AU - Tarasów,Eugeniusz, AU - Kubas,Bozena, AU - Dzienis,Wojciech, AU - Czernikiewicz,Andrzej, AU - Walecki,Jerzy, PY - 2009/1/31/entrez PY - 2009/1/31/pubmed PY - 2009/4/3/medline SP - CR82 EP - 88 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 15 IS - 2 N2 - BACKGROUND: The duration of untreated psychosis (DUP) is a factor associated with the natural course of schizophrenia and an independent predictor of treatment outcome. Recent studies focus on the effects of DUP on the functioning of the nervous system, but the findings are inconsistent. As proton magnetic resonance spectroscopy (1H-MRS) enables the assessment of signals from chemical compounds in vivo, it seems a useful tool to explore this problem. MATERIAL/METHODS: In this study the relationships between DUP and 1H-MRS measurements were investigated. Thirty patients with first-episode schizophrenia and 19 controls were examined. Median DUP was 10 weeks. Voxels were positioned in the following regions of interest: the left frontal lobe, left temporal lobe, and left thalamus. The ratios of N-acetylaspartate (NAA), choline-containing compounds (Cho), myoinositol (mI), and glutamate/glutamine/GABA complex (Glx) to creatine (Cr) and the non-suppressed water signal were determined. RESULTS: There were no significant differences between the whole group of patients and healthy subjects for the analyzed metabolite ratios in any region of interest. No differences were found between the groups of patients with short and long DUP and controls. No significant correlation was observed between DUP and metabolite ratios. CONCLUSIONS: The results of the study may suggest that the relatively short DUP does not influence brain metabolism in first-episode schizophrenia. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/19179972/Duration_of_untreated_psychosis_and_proton_magnetic_resonance_spectroscopy__1H_MRS__findings_in_first_episode_schizophrenia_ L2 - https://www.medscimonit.com/download/index/idArt/869559 DB - PRIME DP - Unbound Medicine ER -