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Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions.
Gynecol Oncol. 2009 Apr; 113(1):115-9.GO

Abstract

OBJECTIVE

To evaluate the effect of multiple human papillomavirus (HPV) infection on the prevalence of cervical intraepithelial neoplasia (CIN) among women undergoing colposcopy following a cytological diagnosis of atypical squamous cells of undetermined significance (ASCUS) or low grade squamous intraepithelial lesions (LSIL).

METHODS

HPV type-specific sequences of 15 high-risk and 10 low risk types were detected by the line probe, INNO-LiPA HPV genotyping assay before colposcopic examination and targeted biopsies. Multinomial logistic regression was used to evaluate the effect of multiple infection on pathologic outcome adjusting for confounders.

RESULTS

The prevalence of HPV infection in the 1218 women enrolled was 69.9% (851/1218). HPV 16 (37.4%), 31 (26.1%), 51 (17.4%), 52 (15.7%) and 18 (14%) were the commonest viral types identified. Overall, the rates of multiple infection were 22.5% (153/680) among subjects with negative colposcopy/biopsy, 63.6% (218/343) and 79.5% (155/195) among those with CIN 1 and CIN>or=2, respectively (p for trend <.001). The corresponding rates among subjects uninfected by HPV 16 or 18 were 13.5% (77/572), 57.4% (112/195) and 62% (48/77), respectively (p for trend <.001). In multinomial logistic regression, the odds ratio of CIN>or=2 in multiple high risk as compared to single high risk HPV infection was 4.33 (95% confidence intervals=2.32-7.14) in the overall population and 2.76 (95% confidence intervals=1.36-5.59) among women uninfected by HPV 16 or 18.

CONCLUSIONS

Multiple HPV infection is a significant risk factor for CIN>or=2 among women undergoing colposcopy because of ASCUS/LSIL.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, IRCCS-Fondazione Policlinico San Matteo and University of Pavia, Viale Golgi, 19 27100 Pavia, Italy. spinillo@smatteo.pv.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19181368

Citation

Spinillo, Arsenio, et al. "Multiple Human Papillomavirus Infection and High Grade Cervical Intraepithelial Neoplasia Among Women With Cytological Diagnosis of Atypical Squamous Cells of Undetermined Significance or Low Grade Squamous Intraepithelial Lesions." Gynecologic Oncology, vol. 113, no. 1, 2009, pp. 115-9.
Spinillo A, Dal Bello B, Gardella B, et al. Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions. Gynecol Oncol. 2009;113(1):115-9.
Spinillo, A., Dal Bello, B., Gardella, B., Roccio, M., Dacco', M. D., & Silini, E. M. (2009). Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions. Gynecologic Oncology, 113(1), 115-9. https://doi.org/10.1016/j.ygyno.2008.12.037
Spinillo A, et al. Multiple Human Papillomavirus Infection and High Grade Cervical Intraepithelial Neoplasia Among Women With Cytological Diagnosis of Atypical Squamous Cells of Undetermined Significance or Low Grade Squamous Intraepithelial Lesions. Gynecol Oncol. 2009;113(1):115-9. PubMed PMID: 19181368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions. AU - Spinillo,Arsenio, AU - Dal Bello,Barbara, AU - Gardella,Barbara, AU - Roccio,Marianna, AU - Dacco',Maria Diletta, AU - Silini,Enrico Maria, Y1 - 2009/01/31/ PY - 2008/11/10/received PY - 2008/12/26/revised PY - 2008/12/30/accepted PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/3/27/medline SP - 115 EP - 9 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 113 IS - 1 N2 - OBJECTIVE: To evaluate the effect of multiple human papillomavirus (HPV) infection on the prevalence of cervical intraepithelial neoplasia (CIN) among women undergoing colposcopy following a cytological diagnosis of atypical squamous cells of undetermined significance (ASCUS) or low grade squamous intraepithelial lesions (LSIL). METHODS: HPV type-specific sequences of 15 high-risk and 10 low risk types were detected by the line probe, INNO-LiPA HPV genotyping assay before colposcopic examination and targeted biopsies. Multinomial logistic regression was used to evaluate the effect of multiple infection on pathologic outcome adjusting for confounders. RESULTS: The prevalence of HPV infection in the 1218 women enrolled was 69.9% (851/1218). HPV 16 (37.4%), 31 (26.1%), 51 (17.4%), 52 (15.7%) and 18 (14%) were the commonest viral types identified. Overall, the rates of multiple infection were 22.5% (153/680) among subjects with negative colposcopy/biopsy, 63.6% (218/343) and 79.5% (155/195) among those with CIN 1 and CIN>or=2, respectively (p for trend <.001). The corresponding rates among subjects uninfected by HPV 16 or 18 were 13.5% (77/572), 57.4% (112/195) and 62% (48/77), respectively (p for trend <.001). In multinomial logistic regression, the odds ratio of CIN>or=2 in multiple high risk as compared to single high risk HPV infection was 4.33 (95% confidence intervals=2.32-7.14) in the overall population and 2.76 (95% confidence intervals=1.36-5.59) among women uninfected by HPV 16 or 18. CONCLUSIONS: Multiple HPV infection is a significant risk factor for CIN>or=2 among women undergoing colposcopy because of ASCUS/LSIL. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/19181368/Multiple_human_papillomavirus_infection_and_high_grade_cervical_intraepithelial_neoplasia_among_women_with_cytological_diagnosis_of_atypical_squamous_cells_of_undetermined_significance_or_low_grade_squamous_intraepithelial_lesions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(09)00006-7 DB - PRIME DP - Unbound Medicine ER -