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APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies.
J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):306-11.JG

Abstract

BACKGROUND

The precise relationship between depression and cognitive decline in older adults is unclear. We investigated the influence of apolipoprotein E (APOE)-epsilon4 genotype in modulating the effect of depressive symptoms on cognitive decline.

METHODS

Prospective cohort study of 1,487 cognitively high-functioning Chinese older adults. Depressive symptoms (Geriatric Depression Scale score >/=5) and Mini-Mental State Examination (MMSE) were assessed at baseline, and cognitive decline (at least 1-point drop in MMSE) at 1-2 years after baseline.

RESULTS

There was no significant difference in cognitive decline between depressed (32.9%) and nondepressed (31.5%) participants in the whole sample or among non-APOE-epsilon4 carriers. Among APOE-epsilon4 carriers, depressed participants showed more cognitive decline (40.0%) than their nondepressed counterparts (28.6%), odds ratio = 2.89, 95% confidence interval: 1.03-8.12; p = .04, after controlling for age, gender, education, vascular risk factors/events, smoking, alcohol drinking, physical functioning, subjective memory complaint, length of follow-up, and baseline MMSE scores (p for interaction = .03).

CONCLUSIONS

Our study suggests that the presence of the APOE-epsilon4 allele significantly enhanced the risk of cognitive decline associated with depressive symptoms. This finding should be independently replicated in future studies.

Authors+Show Affiliations

Gerontological Research Programme, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19181718

Citation

Niti, Mathew, et al. "APOE-epsilon4, Depressive Symptoms, and Cognitive Decline in Chinese Older Adults: Singapore Longitudinal Aging Studies." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 64, no. 2, 2009, pp. 306-11.
Niti M, Yap KB, Kua EH, et al. APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies. J Gerontol A Biol Sci Med Sci. 2009;64(2):306-11.
Niti, M., Yap, K. B., Kua, E. H., & Ng, T. P. (2009). APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 64(2), 306-11. https://doi.org/10.1093/gerona/gln013
Niti M, et al. APOE-epsilon4, Depressive Symptoms, and Cognitive Decline in Chinese Older Adults: Singapore Longitudinal Aging Studies. J Gerontol A Biol Sci Med Sci. 2009;64(2):306-11. PubMed PMID: 19181718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies. AU - Niti,Mathew, AU - Yap,Keng-Bee, AU - Kua,Ee-Heok, AU - Ng,Tze-Pin, Y1 - 2009/01/30/ PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/4/23/medline SP - 306 EP - 11 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J Gerontol A Biol Sci Med Sci VL - 64 IS - 2 N2 - BACKGROUND: The precise relationship between depression and cognitive decline in older adults is unclear. We investigated the influence of apolipoprotein E (APOE)-epsilon4 genotype in modulating the effect of depressive symptoms on cognitive decline. METHODS: Prospective cohort study of 1,487 cognitively high-functioning Chinese older adults. Depressive symptoms (Geriatric Depression Scale score >/=5) and Mini-Mental State Examination (MMSE) were assessed at baseline, and cognitive decline (at least 1-point drop in MMSE) at 1-2 years after baseline. RESULTS: There was no significant difference in cognitive decline between depressed (32.9%) and nondepressed (31.5%) participants in the whole sample or among non-APOE-epsilon4 carriers. Among APOE-epsilon4 carriers, depressed participants showed more cognitive decline (40.0%) than their nondepressed counterparts (28.6%), odds ratio = 2.89, 95% confidence interval: 1.03-8.12; p = .04, after controlling for age, gender, education, vascular risk factors/events, smoking, alcohol drinking, physical functioning, subjective memory complaint, length of follow-up, and baseline MMSE scores (p for interaction = .03). CONCLUSIONS: Our study suggests that the presence of the APOE-epsilon4 allele significantly enhanced the risk of cognitive decline associated with depressive symptoms. This finding should be independently replicated in future studies. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/19181718/APOE_epsilon4_depressive_symptoms_and_cognitive_decline_in_Chinese_older_adults:_Singapore_Longitudinal_Aging_Studies_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/gln013 DB - PRIME DP - Unbound Medicine ER -