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Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy.
J Child Neurol. 2009 Feb; 24(2):176-82.JC

Abstract

The aim of this study was to assess trihexyphenidyl in reducing overall dystonia, improving upper limb function, and achieving goals in children with dystonic cerebral palsy. A randomized, double-blinded, placebo-controlled, crossover trial was conducted with 16 participants at a tertiary children's hospital. Assessments were performed at baseline, week 12, and week 28. The primary outcome measure was the Barry-Albright Dystonia scale for global assessment of dystonia. Secondary measures included the Quality of Upper Extremity Skills Test, Canadian Occupational Performance Measure, and Goal Attainment Scale. A total of 14 children (88%) completed the study. Mean baseline Barry-Albright Dystonia score was 18.4 (95% confidence interval, 15.5-21.2). There were no significant treatment effects as measured by change in outcome scores. There were significant order effects for both the Goal Attainment Scale and performance aspect of the Canadian Occupational Performance Measure. Side effects were common. Larger experimental trials with more narrowly defined functional levels are indicated.

Authors+Show Affiliations

Paediatric Rehabilitation Service, Women's and Children's Hospital, North Adelaide, Australia. james.rice@cywhs.sa.gov.auNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19182155

Citation

Rice, James, and Mary-Clare Waugh. "Pilot Study On Trihexyphenidyl in the Treatment of Dystonia in Children With Cerebral Palsy." Journal of Child Neurology, vol. 24, no. 2, 2009, pp. 176-82.
Rice J, Waugh MC. Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. J Child Neurol. 2009;24(2):176-82.
Rice, J., & Waugh, M. C. (2009). Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. Journal of Child Neurology, 24(2), 176-82. https://doi.org/10.1177/0883073808322668
Rice J, Waugh MC. Pilot Study On Trihexyphenidyl in the Treatment of Dystonia in Children With Cerebral Palsy. J Child Neurol. 2009;24(2):176-82. PubMed PMID: 19182155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. AU - Rice,James, AU - Waugh,Mary-Clare, PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/5/20/medline SP - 176 EP - 82 JF - Journal of child neurology JO - J. Child Neurol. VL - 24 IS - 2 N2 - The aim of this study was to assess trihexyphenidyl in reducing overall dystonia, improving upper limb function, and achieving goals in children with dystonic cerebral palsy. A randomized, double-blinded, placebo-controlled, crossover trial was conducted with 16 participants at a tertiary children's hospital. Assessments were performed at baseline, week 12, and week 28. The primary outcome measure was the Barry-Albright Dystonia scale for global assessment of dystonia. Secondary measures included the Quality of Upper Extremity Skills Test, Canadian Occupational Performance Measure, and Goal Attainment Scale. A total of 14 children (88%) completed the study. Mean baseline Barry-Albright Dystonia score was 18.4 (95% confidence interval, 15.5-21.2). There were no significant treatment effects as measured by change in outcome scores. There were significant order effects for both the Goal Attainment Scale and performance aspect of the Canadian Occupational Performance Measure. Side effects were common. Larger experimental trials with more narrowly defined functional levels are indicated. SN - 1708-8283 UR - https://www.unboundmedicine.com/medline/citation/19182155/Pilot_study_on_trihexyphenidyl_in_the_treatment_of_dystonia_in_children_with_cerebral_palsy_ L2 - http://journals.sagepub.com/doi/full/10.1177/0883073808322668?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -