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Multiphasic acute disseminated encephalomyelitis or pediatric multiple sclerosis: report of an atypical case.
J Child Neurol. 2009 Feb; 24(2):241-6.JC

Abstract

An international panel has recently proposed consensus definitions for pediatric multiple sclerosis and related disorders. These are important diagnostic improvements, but exceptions have been acknowledged. Further insight about clinical overlap between pediatric multiple sclerosis and all forms of relapsing acute disseminated encephalomyelitis may be gained from long-term follow-up. We report an 8-year follow-up of a girl who developed multiple episodes of central nervous system demyelination at the age of 3 years consistent with multiphasic acute disseminated encephalomyelitis. At 10 years of age (7 years after the first clinical event), she developed progressive cognitive deterioration, mood disorder, and headache, suggesting a secondary progressive form of multiple sclerosis. Magnetic resonance imaging and cerebrospinal fluid analysis were equivocal while visual evoked potentials were the sole test in favor of a diagnosis of multiple sclerosis. A multifaceted approach may be needed when dealing with atypical cases of demyelinating disease in young children.

Authors+Show Affiliations

Department of Paediatrics, University of Padova, Padova, Italy. suppiej@pediatria.unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19182166

Citation

Suppiej, Agnese, et al. "Multiphasic Acute Disseminated Encephalomyelitis or Pediatric Multiple Sclerosis: Report of an Atypical Case." Journal of Child Neurology, vol. 24, no. 2, 2009, pp. 241-6.
Suppiej A, Manara R, De Palma L, et al. Multiphasic acute disseminated encephalomyelitis or pediatric multiple sclerosis: report of an atypical case. J Child Neurol. 2009;24(2):241-6.
Suppiej, A., Manara, R., De Palma, L., De Grandis, D., Citton, V., & Battistella, P. A. (2009). Multiphasic acute disseminated encephalomyelitis or pediatric multiple sclerosis: report of an atypical case. Journal of Child Neurology, 24(2), 241-6. https://doi.org/10.1177/0883073808324543
Suppiej A, et al. Multiphasic Acute Disseminated Encephalomyelitis or Pediatric Multiple Sclerosis: Report of an Atypical Case. J Child Neurol. 2009;24(2):241-6. PubMed PMID: 19182166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiphasic acute disseminated encephalomyelitis or pediatric multiple sclerosis: report of an atypical case. AU - Suppiej,Agnese, AU - Manara,Renzo, AU - De Palma,Luca, AU - De Grandis,Domenico, AU - Citton,Valentina, AU - Battistella,Pier Antonio, PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/5/20/medline SP - 241 EP - 6 JF - Journal of child neurology JO - J Child Neurol VL - 24 IS - 2 N2 - An international panel has recently proposed consensus definitions for pediatric multiple sclerosis and related disorders. These are important diagnostic improvements, but exceptions have been acknowledged. Further insight about clinical overlap between pediatric multiple sclerosis and all forms of relapsing acute disseminated encephalomyelitis may be gained from long-term follow-up. We report an 8-year follow-up of a girl who developed multiple episodes of central nervous system demyelination at the age of 3 years consistent with multiphasic acute disseminated encephalomyelitis. At 10 years of age (7 years after the first clinical event), she developed progressive cognitive deterioration, mood disorder, and headache, suggesting a secondary progressive form of multiple sclerosis. Magnetic resonance imaging and cerebrospinal fluid analysis were equivocal while visual evoked potentials were the sole test in favor of a diagnosis of multiple sclerosis. A multifaceted approach may be needed when dealing with atypical cases of demyelinating disease in young children. SN - 1708-8283 UR - https://www.unboundmedicine.com/medline/citation/19182166/Multiphasic_acute_disseminated_encephalomyelitis_or_pediatric_multiple_sclerosis:_report_of_an_atypical_case_ L2 - https://journals.sagepub.com/doi/10.1177/0883073808324543?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -