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Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study.
Aliment Pharmacol Ther 2009; 29(6):662-8AP

Abstract

BACKGROUND

Gastro-oesophageal reflux disease (GERD) is a common disorder associated with substantial reductions in health-related quality of life (HRQL).

AIM

To describe patterns of change in HRQL during 5 years of follow-up in a large population of GERD patients.

METHODS

In 2000, a total of 6215 GERD patients were enrolled in the Progression of GERD (ProGERD) study. During follow-up, patients received any medication considered necessary. HRQL was assessed yearly with the Short-Form 36 and the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaires. Associations between patient characteristics and changes in HRQL were analysed using multiple logistic regression models.

RESULTS

After 5 years, data on HRQL were available for 4597 (74%) patients. Both generic and disease-specific HRQL improved after baseline and remained well above baseline levels in the following years. A clinically relevant decrease in QOLRAD scores was reported by 3-5% of patients. According to our multivariate analysis, a decrease in HRQL was associated with a higher reflux symptom load and the presence of night-time heartburn.

CONCLUSIONS

Only a small minority of the ProGERD population reported a clinically relevant decrease in HRQL, which was associated most strongly with nocturnal heartburn.

Authors+Show Affiliations

Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, 10098 Berlin, Germany. marc.nocon@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19183146

Citation

Nocon, M, et al. "Health-related Quality of Life in Patients With Gastro-oesophageal Reflux Disease Under Routine Care: 5-year Follow-up Results of the ProGERD Study." Alimentary Pharmacology & Therapeutics, vol. 29, no. 6, 2009, pp. 662-8.
Nocon M, Labenz J, Jaspersen D, et al. Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study. Aliment Pharmacol Ther. 2009;29(6):662-8.
Nocon, M., Labenz, J., Jaspersen, D., Leodolter, A., Richter, K., Vieth, M., ... Willich, S. N. (2009). Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study. Alimentary Pharmacology & Therapeutics, 29(6), pp. 662-8. doi:10.1111/j.1365-2036.2008.03921.x.
Nocon M, et al. Health-related Quality of Life in Patients With Gastro-oesophageal Reflux Disease Under Routine Care: 5-year Follow-up Results of the ProGERD Study. Aliment Pharmacol Ther. 2009 Mar 15;29(6):662-8. PubMed PMID: 19183146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study. AU - Nocon,M, AU - Labenz,J, AU - Jaspersen,D, AU - Leodolter,A, AU - Richter,K, AU - Vieth,M, AU - Lind,T, AU - Malfertheiner,P, AU - Willich,S N, PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/8/1/medline SP - 662 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 29 IS - 6 N2 - BACKGROUND: Gastro-oesophageal reflux disease (GERD) is a common disorder associated with substantial reductions in health-related quality of life (HRQL). AIM: To describe patterns of change in HRQL during 5 years of follow-up in a large population of GERD patients. METHODS: In 2000, a total of 6215 GERD patients were enrolled in the Progression of GERD (ProGERD) study. During follow-up, patients received any medication considered necessary. HRQL was assessed yearly with the Short-Form 36 and the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaires. Associations between patient characteristics and changes in HRQL were analysed using multiple logistic regression models. RESULTS: After 5 years, data on HRQL were available for 4597 (74%) patients. Both generic and disease-specific HRQL improved after baseline and remained well above baseline levels in the following years. A clinically relevant decrease in QOLRAD scores was reported by 3-5% of patients. According to our multivariate analysis, a decrease in HRQL was associated with a higher reflux symptom load and the presence of night-time heartburn. CONCLUSIONS: Only a small minority of the ProGERD population reported a clinically relevant decrease in HRQL, which was associated most strongly with nocturnal heartburn. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19183146/Health_related_quality_of_life_in_patients_with_gastro_oesophageal_reflux_disease_under_routine_care:_5_year_follow_up_results_of_the_ProGERD_study_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03921.x DB - PRIME DP - Unbound Medicine ER -