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How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia.
Br J Dermatol. 2009 Mar; 160(3):482-501.BJ

Abstract

Primary cicatricial alopecias (PCAs) are a rare, but important, group of disorders that cause irreversible damage to hair follicles resulting in scarring and permanent hair loss. They may also signify an underlying systemic disease. Thus, it is of paramount importance that clinicians who manage patients with hair loss are able to diagnose these disorders accurately. Unfortunately, PCAs are notoriously difficult conditions to diagnose and treat. The aim of this review is to present a rational and pragmatic guide to help clinicians in the professional assessment, investigation and diagnosis of patients with PCA. Illustrating typical clinical and histopathological presentations of key PCA entities we show how dermatoscopy can be profitably used for clinical diagnosis. Further, we advocate the search for loss of follicular ostia as a clinical hallmark of PCA, and suggest pragmatic strategies that allow rapid formulation of a working diagnosis.

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Authors+Show Affiliations

Harries MJ
Dermatological Sciences, The University of Manchester, Salford Royal Hospital, Manchester M6 8HD, UK. mjharries@doctors.org.uk
Trueb RM
No affiliation info available
Tosti A
No affiliation info available
Messenger AG
No affiliation info available
Chaudhry I
No affiliation info available
Whiting DA
No affiliation info available
Sinclair R
No affiliation info available
Griffiths CE
No affiliation info available
Paus R
No affiliation info available

MeSH

AlgorithmsAlopeciaBiopsyCicatrixDiagnosis, DifferentialHair FollicleHumans

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19183169

Citation

Harries, M J., et al. "How Not to Get Scar(r)ed: Pointers to the Correct Diagnosis in Patients With Suspected Primary Cicatricial Alopecia." The British Journal of Dermatology, vol. 160, no. 3, 2009, pp. 482-501.
Harries MJ, Trueb RM, Tosti A, et al. How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. Br J Dermatol. 2009;160(3):482-501.
Harries, M. J., Trueb, R. M., Tosti, A., Messenger, A. G., Chaudhry, I., Whiting, D. A., Sinclair, R., Griffiths, C. E., & Paus, R. (2009). How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. The British Journal of Dermatology, 160(3), 482-501. https://doi.org/10.1111/j.1365-2133.2008.09008.x
Harries MJ, et al. How Not to Get Scar(r)ed: Pointers to the Correct Diagnosis in Patients With Suspected Primary Cicatricial Alopecia. Br J Dermatol. 2009;160(3):482-501. PubMed PMID: 19183169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. AU - Harries,M J, AU - Trueb,R M, AU - Tosti,A, AU - Messenger,A G, AU - Chaudhry,I, AU - Whiting,D A, AU - Sinclair,R, AU - Griffiths,C E M, AU - Paus,R, Y1 - 2009/01/10/ PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/4/23/medline SP - 482 EP - 501 JF - The British journal of dermatology JO - Br J Dermatol VL - 160 IS - 3 N2 - Primary cicatricial alopecias (PCAs) are a rare, but important, group of disorders that cause irreversible damage to hair follicles resulting in scarring and permanent hair loss. They may also signify an underlying systemic disease. Thus, it is of paramount importance that clinicians who manage patients with hair loss are able to diagnose these disorders accurately. Unfortunately, PCAs are notoriously difficult conditions to diagnose and treat. The aim of this review is to present a rational and pragmatic guide to help clinicians in the professional assessment, investigation and diagnosis of patients with PCA. Illustrating typical clinical and histopathological presentations of key PCA entities we show how dermatoscopy can be profitably used for clinical diagnosis. Further, we advocate the search for loss of follicular ostia as a clinical hallmark of PCA, and suggest pragmatic strategies that allow rapid formulation of a working diagnosis. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/19183169/How_not_to_get_scar_r_ed:_pointers_to_the_correct_diagnosis_in_patients_with_suspected_primary_cicatricial_alopecia_ L2 - https://doi.org/10.1111/j.1365-2133.2008.09008.x DB - PRIME DP - Unbound Medicine ER -