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Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes.
Diabet Med. 2008 Sep; 25(9):1030-5.DM

Abstract

AIMS

To compare the glycaemic response to meals with different fat content in adolescents with Type 1 diabetes mellitus (T1DM) and to investigate associations with gastric emptying.

METHODS

In this randomized, cross-over study, paired results were obtained from seven adolescents with T1DM who ingested on different days two meals with the same carbohydrate and protein content, but different fat and energy content (2 and 38 g fat, 320 and 640 kcal, respectively). Paracetamol was mixed into the meals and gastric emptying was estimated by the paracetamol absorption method. All subjects were normoglycaemic and given 7 IU insulin aspart at commencement of ingestion. Postprandial blood samples were taken during 4 h.

RESULTS

The areas under the curves for plasma glucose and serum paracetamol concentrations were larger after the low-fat than after the high-fat meal during the first 2 h (P = 0.047 and P = 0.041, respectively). The difference between meals in time-to-peak in glucose and paracetamol concentrations did not reach statistical significance (high-fat vs. low-fat meal: 210 min (120-240) vs. 120 min (50-240), P = 0.080 and 120 min (75-180) vs. 60 min (60-120), P = 0.051, respectively). Changes in glucose concentrations correlated with simultaneous changes in paracetamol concentrations (P < 0.001).

CONCLUSIONS

For the first time, we have shown that the initial glycaemic response is reduced after a meal with higher compared with a meal with lower fat content in adolescents with T1DM given a rapid-acting insulin analogue preprandially. The type and dose of preprandial insulin may need adjustment to the fat content of the meal to reach postprandial normoglycaemia.

Authors+Show Affiliations

Paediatric Endocrinology and Diabetes Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden. mskorre@hem.utfors.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19183308

Citation

Lodefalk, M, et al. "Effects of Fat Supplementation On Glycaemic Response and Gastric Emptying in Adolescents With Type 1 Diabetes." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 25, no. 9, 2008, pp. 1030-5.
Lodefalk M, Aman J, Bang P. Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes. Diabet Med. 2008;25(9):1030-5.
Lodefalk, M., Aman, J., & Bang, P. (2008). Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association, 25(9), 1030-5. https://doi.org/10.1111/j.1464-5491.2008.02530.x
Lodefalk M, Aman J, Bang P. Effects of Fat Supplementation On Glycaemic Response and Gastric Emptying in Adolescents With Type 1 Diabetes. Diabet Med. 2008;25(9):1030-5. PubMed PMID: 19183308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes. AU - Lodefalk,M, AU - Aman,J, AU - Bang,P, PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/8/1/medline SP - 1030 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 25 IS - 9 N2 - AIMS: To compare the glycaemic response to meals with different fat content in adolescents with Type 1 diabetes mellitus (T1DM) and to investigate associations with gastric emptying. METHODS: In this randomized, cross-over study, paired results were obtained from seven adolescents with T1DM who ingested on different days two meals with the same carbohydrate and protein content, but different fat and energy content (2 and 38 g fat, 320 and 640 kcal, respectively). Paracetamol was mixed into the meals and gastric emptying was estimated by the paracetamol absorption method. All subjects were normoglycaemic and given 7 IU insulin aspart at commencement of ingestion. Postprandial blood samples were taken during 4 h. RESULTS: The areas under the curves for plasma glucose and serum paracetamol concentrations were larger after the low-fat than after the high-fat meal during the first 2 h (P = 0.047 and P = 0.041, respectively). The difference between meals in time-to-peak in glucose and paracetamol concentrations did not reach statistical significance (high-fat vs. low-fat meal: 210 min (120-240) vs. 120 min (50-240), P = 0.080 and 120 min (75-180) vs. 60 min (60-120), P = 0.051, respectively). Changes in glucose concentrations correlated with simultaneous changes in paracetamol concentrations (P < 0.001). CONCLUSIONS: For the first time, we have shown that the initial glycaemic response is reduced after a meal with higher compared with a meal with lower fat content in adolescents with T1DM given a rapid-acting insulin analogue preprandially. The type and dose of preprandial insulin may need adjustment to the fat content of the meal to reach postprandial normoglycaemia. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/19183308/Effects_of_fat_supplementation_on_glycaemic_response_and_gastric_emptying_in_adolescents_with_Type_1_diabetes_ L2 - https://doi.org/10.1111/j.1464-5491.2008.02530.x DB - PRIME DP - Unbound Medicine ER -