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Development of nifedipine-loaded coated gelatin microcapsule as a long acting oral delivery.
Arch Pharm Res. 2009 Jan; 32(1):127-32.AP

Abstract

To develop the long acting nifedipine oral delivery with enhanced bioavailability, nifedipine-loaded gelatin microcapsule containing nifedipine and ethanol in gelatin shell was prepared using a spray-dryer, and then coated microcapsule was prepared by coating the gelatin microcapsule with Eudragit acrylic resin. The dissolution test and the bioavailability of the coated microcapsule in rats were evaluated compared to nifedipine powder. The amount of nifedipine dissolved from gelatin microcapsule for 30 min increased about 5-fold compared to nifedipine powder in pH 1.2 simulated gastric fluid. Nifedipine released from the coated microcapsule was retarded in pH 1.2 simulated gastric fluid compared with that from gelatin microcapsule. Furthermore, the coated gelatin microcapsule maintained the plasma level of nifedipine over 4 h and gave significantly higher AUC of nifedipine than nifedipine powder. Thus, the Eudragit-coated gelatin microcapsule, which could maintain the plasma level of nifedipine over a longer period without the initial burst-out plasma concentration, is a preferable delivery system for poorly water-soluble nifedipine.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19183885

Citation

Li, Dong Xun, et al. "Development of Nifedipine-loaded Coated Gelatin Microcapsule as a Long Acting Oral Delivery." Archives of Pharmacal Research, vol. 32, no. 1, 2009, pp. 127-32.
Li DX, Kim JO, Oh DH, et al. Development of nifedipine-loaded coated gelatin microcapsule as a long acting oral delivery. Arch Pharm Res. 2009;32(1):127-32.
Li, D. X., Kim, J. O., Oh, D. H., Lee, W. S., Hong, M. J., Kang, J. Y., Choi, J. S., Woo, J. S., Yong, C. S., & Choi, H. G. (2009). Development of nifedipine-loaded coated gelatin microcapsule as a long acting oral delivery. Archives of Pharmacal Research, 32(1), 127-32. https://doi.org/10.1007/s12272-009-1126-0
Li DX, et al. Development of Nifedipine-loaded Coated Gelatin Microcapsule as a Long Acting Oral Delivery. Arch Pharm Res. 2009;32(1):127-32. PubMed PMID: 19183885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of nifedipine-loaded coated gelatin microcapsule as a long acting oral delivery. AU - Li,Dong Xun, AU - Kim,Jong Oh, AU - Oh,Dong Hoon, AU - Lee,Won Seok, AU - Hong,Myung Ja, AU - Kang,Jin Yang, AU - Choi,Jong Seo, AU - Woo,Jong Soo, AU - Yong,Chul Soon, AU - Choi,Han-Gon, Y1 - 2009/01/29/ PY - 2008/03/22/received PY - 2008/09/09/accepted PY - 2008/04/15/revised PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/2/28/medline SP - 127 EP - 32 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 32 IS - 1 N2 - To develop the long acting nifedipine oral delivery with enhanced bioavailability, nifedipine-loaded gelatin microcapsule containing nifedipine and ethanol in gelatin shell was prepared using a spray-dryer, and then coated microcapsule was prepared by coating the gelatin microcapsule with Eudragit acrylic resin. The dissolution test and the bioavailability of the coated microcapsule in rats were evaluated compared to nifedipine powder. The amount of nifedipine dissolved from gelatin microcapsule for 30 min increased about 5-fold compared to nifedipine powder in pH 1.2 simulated gastric fluid. Nifedipine released from the coated microcapsule was retarded in pH 1.2 simulated gastric fluid compared with that from gelatin microcapsule. Furthermore, the coated gelatin microcapsule maintained the plasma level of nifedipine over 4 h and gave significantly higher AUC of nifedipine than nifedipine powder. Thus, the Eudragit-coated gelatin microcapsule, which could maintain the plasma level of nifedipine over a longer period without the initial burst-out plasma concentration, is a preferable delivery system for poorly water-soluble nifedipine. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/19183885/Development_of_nifedipine_loaded_coated_gelatin_microcapsule_as_a_long_acting_oral_delivery_ L2 - https://dx.doi.org/10.1007/s12272-009-1126-0 DB - PRIME DP - Unbound Medicine ER -